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Ashley Williams

As seen in: AIChE Journal, Nature, Wiley Online Library, SAGE Publishing, UC Berkeley News, ACS Publications, JAMA Network, Cell Reports, Cell Metabolism, Cell Press and
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Articles

Trimodal single-cell profiling of transcriptome, epigenome and 3D genome in complex tissues with scHiCAR - Nature Biotechnology

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By Xiaolin Wei, Yueyuan Xu, Dongchan Yang, Kyukwang Kim, Lizhi Yi, Wenzhe Luo, Xin Lin, Yu Xiang, Ashley Williams, Xiaotao Wang, Sweta Srivas, Christabel Xin Tan, Kan Zhang, Wei Li, Feng Yue, Z. Huang, Inkyung Jung, Yarui Diao
| Nature Verified
Abstract The three-dimensional (3D) organization of cis-regulatory elements (CREs) is critical in transcription control. However, capturing transcriptome, epigenome and 3D genome from the same single cells remains challenging. Here we present scHiCAR (single-cell Hi-C with assay for transposase-accessible chromatin and RNA sequencing), a plate-based combinatorial barcoding method that simultaneously profiles mRNA, open chromatin and chromosome conformation capture from the same cells.
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Zeroing in on Firearm Injury Prevention Efforts

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By Ashley Williams
| JAMA Network Verified
Polcari et al1 offer convincing proof that neighborhood deprivation is more strongly associated with firearm injuries than the strength of state firearm laws. While stricter firearm laws are associated with lower injury and mortality rates,2 this study recognizes that firearm legislation is not a sole antidote to firearm violence. Rather, a multipronged approach is needed.
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Daily Step Count 2 Years After Anterior Cruciate Ligament Reconstruction and Associations With Cartilage Health and Knee Symptoms and Function

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By Britt Elin Øiestad, Ashley Williams, Matthew R. Titchenal, Amelie M. Lutz
| SAGE Publishing
Abstract Background: People suffering anterior cruciate ligament (ACL) injuries are at increased risk for development of osteoarthritis (OA). This study investigated associations between daily step count, cartilage degeneration and patient-reported outcomes 2 years after ACL reconstruction (ACLR). Hypothesis: Daily step count is associated with cartilage health and patient-reported knee symptoms and function 2 years after ACLR. Study Design: Cross-sectional. Level of Evidence: Level 4.
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