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GPR15-guided CD8 + T regulatory cells control intestinal inflammation
Abstract Inflammatory bowel disease (IBD) causes chronic suffering from gastrointestinal inflammation and dysfunction that can progress to colon cancer1,2. The disease prevalence is increasing and there is an urgent need to better understand its pathogenic mechanisms to improve treatment.
Genetic Screening of the Patients with Primary Immunodeficiency by Whole-Exome Sequencing
Introduction Primary immunodeficiencies (PIDs) are congenital disorders of immune system. The most common clinical symptoms in PID patients are high susceptibility to infections, inflammation, allergy, malignancies, and autoimmunity.1 The vast majority of PID diseases shows monogenic inheritance and almost 400 genetic defects have been identified so far.2 The overall prevalence of PIDs is ∼1:10,000.
IgE and IgG4 binding to lentil epitopes in children with red and green lentil allergy
ORIGINAL Cansin Sackesen https://orcid.org/0000-0002-1115-9805 Division of Pediatric Allergy, Koc University, School of Medicine, Istanbul, Turkey Division of Pediatric Allergy, Hacettepe University School of Medicine, Ankara, Turkey Division of Pediatric Allergy and Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA These authors contributed equally to the work and are co‐first authors Search for more papers by this author Hugh A.
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