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Barbara Sheehan Withers on Muck Rack

Barbara Sheehan Withers

As seen in: Nature, Wiley, Wiley Online Library, Memory Studies, Tallahassee Democrat, emerald insight
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Articles

Novel chimeric PD-L1::PD-L2 fusion and immune evasion in lymphoma

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By Joshua M. L. Casan, Fatimah B. Jalud, Kaitlyn Kew, Ing Soo Tiong, Francesca Watts, Scott Williams, Jesse Rudd-Schmidt, Satwica Yerneni, Barbara Sheehan Withers, Piers Blombery, Teresa Sadras
| Nature Verified
Abstract We report a novel in-frame CD274::PDCD1LG2 fusion in primary mediastinal B-cell lymphoma. Functional studies using expression constructs and CRISPR-engineered lymphoma cells confirmed formation of a PD-L1::PD-L2 chimeric protein and marked upregulation of PD-L1 surface expression, consistent with loss of 3′-UTR-mediated repression.
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A roadmap for establishing institutional readiness for cellular therapies targeting solid tumours and autoimmune diseases

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By Sarah Childs, David Ma, Elizabeth Houghton, Rasha Cosman, Jennifer Massey, Venessa T. Chin, Amanda L. McLaughlin, Simon Goodwin, Barbara Sheehan Withers, Callie Noakes, Annabel Horne, Jessica Boyd, Dion Forstner, Anthony J Rodrigues, Geeta Sandhu, Karim Ibrahim, Chloe Martin, Benjamin Kwan, Hergen Buscher, Philip J. Cunningham, Anthony M. Joshua, Laila Girgis, Ben Tran, Jayesh Desai, Simon Harrison, John Moore, Jia Liu, Valerie Valencia, Aaron O’Grady, Simone Kay Jensen, Helen Tao, Paul Preisz, Nicolas De Luca
| Nature Verified
Abstract Adoptive cellular therapies have revolutionised treatment of haematological malignancies and demonstrate potential in solid tumours and autoimmune disease. Real-world implementation remains limited by biological, logistical, and manufacturing barriers, restricting global uptake despite a rapidly expanding clinical trial portfolio. Effective implementation requires national and institutional readiness, multidisciplinary collaboration, scalable manufacturing, and robust infrastructure.
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Efficacy of bortezomib, cyclophosphamide and dexamethasone in cardiac AL amyloidosis

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By Xavier Brennan, Barbara Sheehan Withers, Andrew Jabbour, Sam Milliken
| Wiley Online Library Verified
Abstract Cardiac light chain (AL) amyloidosis is a condition with a very poor prognosis. We report a retrospective analysis comparing the traditional melphalan and dexamethasone protocol with cyclophosphamide, bortezomib and dexamethasone in late-stage cardiac AL amyloidosis. The primary end points were overall survival and haematological response. Both regimens provided meaningful responses in this difficult to treat patient group.
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