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Reanalysis of Study After Removal of Participants in 1 Trial of Upadacitinib for Atopic Dermatitis
Reanalysis of Study After Removal of Participants in 1 Trial of Upadacitinib for Atopic Dermatitis Upadacitinib Treatment in Adolescents With Atopic Dermatitis Amy S. Paller, MD, MS; Barry Ladizinski, MD, MPH, MBA; Pedro Mendes-Bastos, MD; Elaine Siegfried, MD; Weily Soong, MD; Vimal H. Prajapati, MD; Peter Lio, MD; Jacob P. Thyssen, MD, PhD, DmSci; Eric L. Simpson, MD, MCR; Andrew M. Platt, PhD; Eliza M. Raymundo, MD; Jianzhong Liu, MD, MS; Brian M.
Efficacy and Safety of Upadacitinib Treatment in Adolescents With Moderate-to-Severe Atopic Dermatitis: Analysis of the Measure Up 1, Measure Up 2, and AD Up Randomized Clinical Trials | Adolescent Medicine | JAMA Dermatology | JAMA Network
Key Points Question Does upadacitinib safely improve moderate-to-severe atopic dermatitis in adolescents? Findings Among 552 adolescents participating in 3 randomized clinical trials, upadacitinib administered once daily was generally well tolerated through 16 weeks.
Characterization of acne associated with upadacitinib treatment in patients with moderate-to-severe atopic dermatitis: A post hoc integrated analysis of 3 phase 3 randomized, double-blind, placebo-controlled trials
Background Acne is the most frequent adverse event associated with upadacitinib treatment in patients with moderate-to-severe atopic dermatitis. Objective To characterize the adverse event of acne associated with upadacitinib. Methods This was a post hoc integrated analysis of 3 phase 3 randomized, double-blind, placebo-controlled trials of upadacitinib, alone (NCT03569293 and NCT03607422) or in combination with topical corticosteroids (NCT03568318).
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