Bart L Haagmans
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Mapping SARS-CoV-2 immunity after an XBB.1.5 booster by antigenic cartography of merged human and hamster sera
Abstract The ongoing evolution of SARS-CoV-2, particularly the emergence and rapid spread of new immune-evasive variants, continues to challenge the durability of vaccine-induced protection. Understanding how repeated variant exposures shape neutralizing antibody breadth is therefore essential for optimizing booster design.
Human MERS-CoV cases are falling but pose an ongoing pandemic threat
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Human cases of Middle East respiratory syndrome coronavirus (MERS-CoV) have declined in recent years, but continued surveillance and research is needed to understand this trend and mitigate future zoonotic threats.
By Lorenzo Subissi, James R. Otieno, Laith Jamal Abu-Raddad, Anurag Agrawal, Amal Z. Barakat, Leon Caly, Meera A Chand, Christian Drosten, Nuno R Faria, Adeola Fowotade, Anne von Gottberg, Bart L Haagmans, Baoying Huang, Jason Kindrachuk, Marion Koopmans, Bette Korber, Yee-Sin Leo, Placide Mbala-Kingebeni, Nada M Melhem, Vincent J. Munster, Isaac Ngere, M. Kariuki Njenga, Tulio de Oliveira, Gustavo Palacios, Malik Peiris, Andrew Rambaut, Paola Cristina Resende, Senjuti Saha, Tadaki Suzuki, Pragya D. Yadav, Sophie von Dobschuetz, Esam I Azhar, Maria Van Kerkhove, Ahmed Mohammed Albarraq, Ismail Mahat Bashir
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Nature
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Two-year persistence of MERS-CoV-specific antibody and T cell responses after MVA-MERS-S vaccination in healthy adults - Nature Communications
Abstract MVA-MERS-S, a vaccine candidate against Middle East respiratory syndrome (MERS), was recently evaluated in a randomized, placebo-controlled, double-blind phase 1b clinical trial to assess its safety, immunogenicity, and optimal dosing in healthy adults in Hamburg and Rotterdam. A three-dose regimen was safe and elicited robust spike-specific antibody responses.
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