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Beamon Agarwal

As seen in: Nature, Archives of Pathology
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Articles by Beamon Agarwal

Chromatin rewiring of β-globin and MYC enhancers by TGF-β1 drives defective erythropoiesis

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By Srinivas Aluri, Kimo Bachiashvili, Jong Jin Jeong, Shanisha Gordon-Mitchell, Samarpana Chakraborty, Jung-In Yang, Srabani Sahu, Sanjay Pandey Verified, Mahinder Paul, Wenjun Deng, Rahul Sanawar, Leah Kravets, Sarah Aminov, Ritesh Aggarwal, Beamon Agarwal, Divij Verma, Gaurav Choudhary, Tushar D. Bhagat, Milagros Carbajal, Rongbao Zhao, Kith Pradhan, Shahina Maqbool, Seong-Jin Kim, Ulrich Steidl, Aditi Shastri, Marc H.G.P. Raaijmakers, Andrea Pellagatti, Jacqueline Boultwood, Amittha Wickrema, Anjali Budhathoki, Micheal Sandhu, Plabani Sahu
| Nature Verified
Abstract Erythropoiesis is a tightly regulated process involving rapid cell proliferation with orderly differentiation to ensure production of millions of RBCs. TGF-β1 is a key regulator of erythropoiesis, however, the mechanisms via which it regulates erythropoiesis are not well elucidated. Using myelodysplastic syndromes patient samples, we show that elevated TGF-β1 and SMAD2 signaling correlates with the degree of anemia.
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Neonatal kidney injury in the hyperoxia-induced bronchopulmonary dysplasia mouse models: effect on morphology and biomarkers

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By Fred Graumuller, Divya Rajendran, Beamon Agarwal, Pragnya Das, Vineet Bhandari, Theesitha Srikanth, Xander Takada
| Nature Verified
Abstract Preterm infants have reduced nephrons at birth and are exposed to hyperoxic environments. The objective was to examine the effects of hyperoxia on renal injury. We utilized a mouse model of experimental moderate (60% O2)-severe (100% O2) bronchopulmonary dysplasia (BPD), obtaining kidney tissue on postnatal day 14. The number of glomeruli, glomerulus length, and Bowman’s capsule’s length were recorded. Cell death and expression of multiple biomarkers were assessed.
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Lactate-mediated epigenetic reprogramming regulates formation of human pancreatic cancer-associated fibroblasts

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By Tushar D. Bhagat, Yiyu Zou, Joelle Baddour, Abhinav Achreja, Lifeng Yang, Brijesh Patel Verified, Gaurav Choudhary, Srinivas Aluri, Sanchari Bhattacharyya, Matthias Bartenstein, Masako Suzuki, Davendra Sohal, Sonal Gupta, Paola A. Guerrero, Surinder K. Batra, Michael Goggins, Ulrich Steidl, John M. Greally, Kith Pradhan, Deepak Nagrath, Anirban Maitra, Dagny Von Ahrens, Meelad Dawlaty, Hongyun Zhao, Changsoo Kwak, Shanisha Gordon-Mitchell, Srabani Sahu, Yiting Yu, Orsi Giricz, Beamon Agarwal, Debabrata Banerjee
| eLife
Abstract Even though pancreatic ductal adenocarcinoma (PDAC) is associated with fibrotic stroma, the molecular pathways regulating the formation of cancer associated fibroblasts (CAFs) are not well elucidated. An epigenomic analysis of patient-derived and de-novo generated CAFs demonstrated widespread loss of cytosine methylation that was associated with overexpression of various inflammatory transcripts including CXCR4.
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