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Articles by Benjamin Jacobs
Contemporary outcomes of open conversion after failed endovascular aortic aneurysm repair from a high-volume aortic center Presented at the Fiftieth Annual Meeting of the Southern Association for Vascular Surgery, Nassau, Bahamas, January 22-24, 2026.
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Pre‐Diagnostic Features of Multiple Sclerosis in a Diverse UK Cohort: A Nested Case-Control Study
1 Introduction Multiple sclerosis (MS) is a chronic, disabling neurodegenerative disease and a leading cause of neurological dysfunction and disability in young adults [1]. MS is a global disease and can occur in people of any ethnicity [2]. Approximately 2.2–2.3 million people worldwide live with MS, of whom around 150,000 live in the United Kingdom (UK) [3].
Genome-wide analyses identify 25 infertility loci and relationships with reproductive traits across the allele frequency spectrum - Nature Genetics
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Abstract Genome-wide association studies (GWASs) may help inform the etiology of infertility. Here, we perform GWAS meta-analyses across seven cohorts in up to 42,629 cases and 740,619 controls and identify 25 genetic risk loci for male and female infertility. We additionally identify up to 269 genetic loci associated with follicle-stimulating hormone, luteinizing hormone, estradiol and testosterone through sex-specific GWAS meta-analyses (n = 6,095–246,862).
By Samvida Venkatesh, Duncan Palmer, Nikolas Baya, Melody Parker Verified, Mie T Bruun, Christian Erikstrup, Anders Juul, Christina Mikkelsen, Henriette S. Nielsen, Sisse R. Ostrowski, Ole B. Pedersen, Palle Duun Rohde, Erik S. Sørensen, David Westergaard, Asgeir Haraldsson, Hilma Holm, Ingileif Jónsdóttir, Valgerdur Steinthorsdottir, Gudmar Thorleifsson, Minna K. Karjalainen, Benjamin Jacobs, Georgios Kalantzis, Nikki Hubers, Margaret Lippincott, Deborah A. Lawlor, Nicholas J Timpson, Mette Nyegaard, Kari Stefansson, Reedik Mägi, Hannele Laivuori, Dorret I. Boomsma, Ravikumar Balasubramanian, Yee-Ming Chan, Triin Laisk, Bitten Aagard Jensen
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Nature
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The Implications of Oxygen Dependent Chronic Obstructive Pulmonary Disease on Sac Growth and Mortality Following Endovascular Aneurysm Repair
Keywords Vascular Quality Initiative EVAR COPD Sac Growth Get full text access Log in, subscribe or purchase for full access. References 1. Adeloye, D. ∙ Song, P. ∙ Zhu, Y. ... Global, regional, and national prevalence of, and risk factors for, chronic obstructive pulmonary disease (COPD) in 2019: a systematic review and modelling analysis The Lancet Respiratory Medicine. 2022; 10:447-458 2. Müller, V. ∙ Miszczuk, M. ∙ Althoff, C.E. ... Comorbidities associated with large abdominal aortic aneurysms Aorta.
Use Of A Wireless Pressure Sensor To Prevent Temporal Losses In Sub-bandage Pressure During Compression Therapy
Compression therapy for treatment of venous leg ulcers (VLUs) requires consistent and prolonged pressure to facilitate healing, but commercially available bandages can loosen over time. A multi-point wireless pressure sensor (MPS) continuously monitors sub-bandage pressure and identifies changes in sub-bandage pressure that occur with limb decongestion, material fatigue, or bandage disassembly.
Genetic determinants of Multiple Sclerosis susceptibility in diverse ancestral backgrounds
The authors have declared no competing interest. This work was supported by a Medical Research Council (MRC) Clinical Research Training Fellowship (CRTF) jointly funded by the UK MS Society (BMJ; grant reference: MR/V028766/1), by AIMS2CURE, and Barts Charity. BMJ is currently funded by a Guarantors of Brain post-doctoral fellowship. I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
Single-cell analysis of cerebrospinal fluid reveals common features of neuroinflammation
Keywords: multiple sclerosis single-cell sequencing clonal expansion oligoclonal bands neuroinflammation cerebrospinal fluid omics Introduction One of the core features of the vertebrate adaptive immune response is the rapid clonal proliferation of specific lymphocytes on encountering antigen.1 This process is vital to efficiently control infections and malignancy but, when aberrantly activated or inadequately regulated, can result in autoimmune disease.2,3,4 The cerebrospinal fluid (CSF),...
Hugh Michael Wieselberg
Stephen Herman, Benjamin Jacobs Herman S, Jacobs B. Hugh Michael Wieselberg BMJ 2024; 387 :q2223 doi:10.1136/bmj.q2223
Genetic architecture of routinely acquired blood tests in a British South Asian cohort - Nature Communications
Abstract Understanding the genetic basis of routinely-acquired blood tests can provide insights into several aspects of human physiology. We report a genome-wide association study of 42 quantitative blood test traits defined using Electronic Healthcare Records (EHRs) of ~50,000 British Bangladeshi and British Pakistani adults. We demonstrate a causal variant within the PIEZO1 locus which was associated with alterations in red cell traits and glycated haemoglobin.
The relationship between ethnicity and multiple sclerosis characteristics in the United Kingdom: A UK MS Register study
Introduction Multiple sclerosis (MS) affects individuals from all ethnic backgrounds.1–9 It has been suggested that ethnicity may be associated with differences in MS disease course, including age at onset, speed of progression and response to treatment.
Comparative outcomes of open mesenteric bypass after a failed endovascular or open mesenteric revascularization for chronic mesenteric ischemia
Introduction: Clinical practice guidelines have recommended an endovascular-first approach (ENDO) for the management of patients with chronic mesenteric ischemia (CMI), whereas an open mesenteric bypass (OMB) is proposed for subjects deemed to be poor ENDO candidates. However, the impact of a previous failed endovascular or open mesenteric reconstruction on a subsequent OMB is unknown.
Neuroanatomical and prognostic associations of depression in Parkinson’s disease
Exposure and outcome definitions Depression, PD and dementia diagnoses, and date of diagnoses, were ascertained through linked primary healthcare records, inpatient hospital records, self-report and death certificate registration (see online supplemental table 2). A sensitivity analysis was conducted where only primary healthcare and inpatient hospital records were used to define depression diagnosis (online supplemental materials). Death was ascertained through death certificate registration.
The relationship between ethnicity and Multiple Sclerosis characteristics in the United Kingdom: a UK MS Register study
The authors have declared no competing interest. BMJ is funded by an Medical Research Council (MRC) Clinical Research Training Fellowship (CRTF) jointly supported by the UK MS Society (BMJ; grant reference: MR/V028766/1). This work was carried out at the Centre for Preventive Neurology Unit at Queen Mary University of London, which is partly funded by Barts Charity. The UK MS Register is funded by the UK MS Society.
Plasma proteomic profiles of UK Biobank participants with multiple sclerosis
Introduction Blood-based protein biomarkers have several properties which make them attractive adjuncts in the diagnosis, monitoring, and prognostication of multiple sclerosis (MS). Proteins are often abundant in serum/plasma, stable in solution, and are straightforward to quantify. Furthermore plasma is easier to obtain than cerebrospinal fluid or magnetic resonance imaging (MRI) scans, particularly if regular measurements are required for ongoing monitoring.
Plasma proteomic profiles of UK Biobank participants with Multiple Sclerosis
The authors have declared no competing interest. BMJ is funded by a Medical Research Council (MRC) Clinical Research Training Fellowship (CRTF) jointly supported by the UK MS Society (BMJ; grant reference MR/V028766/1), and by Barts Charity. The Preventive Neurology Unit is supported by a grant from Barts Charity. I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
Genome-wide association study of thyroid-stimulating hormone highlights new genes, pathways and associations with thyroid disease - Nature Communications
Abstract Thyroid hormones play a critical role in regulation of multiple physiological functions and thyroid dysfunction is associated with substantial morbidity. Here, we use electronic health records to undertake a genome-wide association study of thyroid-stimulating hormone (TSH) levels, with a total sample size of 247,107.
ADRA2A and IRX1 are putative risk genes for Raynaud’s phenomenon - Nature Communications
Abstract Raynaud’s phenomenon (RP) is a common vasospastic disorder that causes severe pain and ulcers, but despite its high reported heritability, no causal genes have been robustly identified. We conducted a genome-wide association study including 5,147 RP cases and 439,294 controls, based on diagnoses from electronic health records, and identified three unreported genomic regions associated with the risk of RP (p < 5 × 10−8).
Army MEDCOM Provides Vital Support to NAVSUP FLC Norfolk Navy Food Management Team Mission
1 When the NAVSUP FLC Norfolk Navy Food Management Team (NFMT) boards a ship to provide training, the ship’s food service team might be surprised to find a Soldier as part of the training team. They quickly learn that the Soldier is a vital part of NFMT. The U.S. Army Medical Command’s (MEDCOM) Army Veterinary Services (AVS) supports NFMT with Army Veterinary Food Inspectors (VFIs). They, along with NFMT Sailors, conduct assist visits and training aboard ships and classroom training.
Serum proteomic profiles of UK Biobank participants with Multiple Sclerosis
Abstract Discovery of serum protein biomarkers for Multiple Sclerosis risk and severity could shed light on pathophysiological mechanisms, suggest new drug targets, enhance the speed of diagnosis, and improve risk stratification algorithms for use in clinical practice or in the identification of high-risk participants for prevention trials. Prior proteome-wide studies of Multiple Sclerosis have yielded inconsistent results due to small sample sizes.
Re: Folic acid: The case to rethink the UK’s food fortification plans
Dear Editor This article provides an important overview of the cases for and against fortification of food with Folic acid. It accidentally also provides a wonderful new name for this vitamin: "Benign vitamin B". Presumably this was meant to read "Vitamin B9" but Artificial Intelligence voice recognition software tripped up. A nice new name nevertheless. Competing interests: No competing interests
ADAMS project: a genetic Association study in individuals from Diverse Ancestral backgrounds with Multiple Sclerosis based in the UK
http://orcid.org/0000-0002-6023-6010Benjamin M Jacobs1, Luisa Schalk1, Angie Dunne2, Antonio Scalfari3, Ashwini Nandoskar4, Bruno Gran5, Charles A Mein6, Charlotte Sellers1, Cord Spilker7, David Rog8, Elisa Visentin9, Elizabeth Lindsey Bezzina10, Emeka Uzochukwu11, Emma Tallantyre11,12, Eva Wozniak6, Eve Sacre2, Ghaniah Hassan-Smith13, Helen L Ford2, Jade Harris14, Joan Bradley15, Joshua Breedon1, Judith Brooke14, Karim L Kreft16, Katherine Tuite Dalton17, Katila George1, Maria...
The Legal Intelligencer Recognizes Morgan Lewis in 2023 Professional Excellence Awards
PHILADELPHIA and PITTSBURGH, April 19, 2023: Morgan Lewis and three of the firm’s partners have been named among winners of The Legal Intelligencer’s 2023 Professional Excellent Awards. The annual awards recognize the work and achievements of lawyers within the Pennsylvania legal community across a variety of categories.
US MED-EQUIP, LLC v. AGILITI, INC. et al
March 31, 2023 Filing 6 NOTICE of Appearance by ANTONIA MORAN on behalf of US MED-EQUIP, LLC (MORAN, ANTONIA) March 31, 2023 Filing 5 NOTICE of Appearance by SHANNON AMMON on behalf of US MED-EQUIP, LLC (AMMON, SHANNON) March 31, 2023 Filing 4 Disclosure Statement Form pursuant to FRCP 7.1 including ORG USME Buyer, LLC with Certificate of Service by US MED-EQUIP, LLC.(JACOBS, BENJAMIN) March 31, 2023 Filing 3 MOTION to Expedite Discovery filed by US MED-EQUIP, LLC.Memorandum, Certificate of...
Association Between Antiepileptic Drugs and Incident Parkinson Disease
[Skip to Navigation] Figure. Forest Plot of Odds Ratios (ORs) of Number of Different Antiepileptic Drugs (AEDs) and Number of AEDs Issues for Parkinson Disease (PD) JAMA Neurol. 2023;80(2):183-187. doi:10.1001/jamaneurol.2022.4699 Key Points Question Are antiepileptic drugs (AEDs) associated with increased risk of developing Parkinson disease (PD)?
Outcomes of Open Mesenteric Bypass after Prior Failed Endovascular or Open Mesenteric Revascularization for Acute and Chronic Mesenteric Ischemia
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Towards a global view of multiple sclerosis genetics - Nature Reviews Neurology
The Global Burden of Disease Study revealed global variation in the prevalence of MS30. Age-standardized estimates range from 2.0 per 100,000 people in Oceania and 2.8 per 100,000 in central sub-Saharan Africa to 164.6 per 100,000 in high-income North America30. Although the estimates for many of the countries with low prevalence are influenced by ascertainment bias and missing data, the differences are striking30.
Pennsylvania Amends Overtime Rate Calculations for Salaried, Nonexempt Employees | JD Supra
Pennsylvania employers with salaried, nonexempt employees working in the commonwealth may need to adjust how they calculate overtime premiums for these employees in light of amendments to the Pennsylvania Minimum Wage Act that will go into effect on August 5. The amendments codify that Pennsylvania employers cannot use the fluctuating workweek method of calculating overtime pay for salaried employees.
Re: Consenting children aged under 18 for vaccination and treatment
Dear Editor The title of this paper wrongly uses the word ‘consent’ as a transitive verb. This usage is wrong. It is demeaning to patients. The verb “consent” has been intransitive since it entered the English language in the 1200s. It is only in modern times, and only in medical parlance, that people have started to talk about "consenting" others. It should be the child who may consent to the vaccine, not the vaccinator who "consents" the child. Medical people should know better.
One Step GPS Announces Tracking One Million Vehicles by Original
SAN FERNANDO, CA, April 20, 2022 (GLOBE NEWSWIRE) -- One Step GPS, a GPS fleet tracking software company announces a new target of equipping 1 million vehicles with their GPS technology by 2025. The announcement made by the company comes just after receiving a place on the 2022 Inc 5000 Regionals Pacific list on March 15th. One Step GPS is channeling greater resources to become the first-choice GPS tracking software provider on the market, with keen focus on customer support.
Re: Effect of dietary sources of calcium and protein on hip fractures and falls in older adults in residential care: cluster randomised controlled trial
Dear Editor Reducing fractures in the elderly would surely reduce mortality. The similar mortality rates in the 2 groups makes me suspect that those with less fractures had a higher incidence of death due to non-fracture diseases, perhaps cardiovascular or renal effects of excess calcium?
Evaluation of remote assessments for multiple sclerosis in an in-home setting
Highlights • Remote outcome measures are increasingly important in monitoring disability in people with MS • There is a moderate positive correlation between web EDSS and timed 25 foot walk • The correlation between web EDSS and 9 hole peg test is less strong, reflecting the complementary information gathered in the two assessments • Objective remote testing has potential utility, with values obtained reflecting those seen in clinical practice Abstract Background: There is an urgent clinical...
Gene-Environment Interactions in Multiple Sclerosis
Abstract Objective We sought to determine whether genetic risk modifies the effect of environmental risk factors for multiple sclerosis (MS). To test this hypothesis, we tested for statistical interaction between polygenic risk scores (PRS) capturing genetic susceptibility to MS and environmental risk factors for MS in UK Biobank. Methods People with MS were identified within UK Biobank using ICD-10–coded MS or self-report.
Big data, machine learning and artificial intelligence: a neurologist’s guide
Big data, machine learning and artificial intelligence: a neurologist’s guide http://orcid.org/0000-0002-5911-7049Stephen D Auger1, http://orcid.org/0000-0002-6023-6010Benjamin M Jacobs1,2, http://orcid.org/0000-0002-2993-585XRuth Dobson1,2, Charles R Marshall1,2, Alastair J Noyce1,2 1 Preventive Neurology Unit, Wolfson Institute of Preventive Medicine, Queen Mary University of London, UK 2 Department of Neurology, Royal London Hospital, London, UK Correspondence to Stephen D Auger,...
Lower Lymphocyte Count is Associated With Increased Risk of Parkinson's Disease
Abstract Objectives Patients with established Parkinson's disease (PD) display differences in peripheral blood markers of immune function, including leukocyte differential counts, compared with controls. These differences may be useful biomarkers to predict PD and may shed light on pathogenesis. We sought to identify whether peripheral immune dysregulation was associated with increased risk of subsequent PD diagnosis.
Big data, machine learning and artificial intelligence: a neurologist’s guide
Big data, machine learning and artificial intelligence: a neurologist’s guide http://orcid.org/0000-0002-5911-7049Stephen D Auger1, http://orcid.org/0000-0002-6023-6010Benjamin M Jacobs1,2, http://orcid.org/0000-0002-2993-585XRuth Dobson1,2, Charles R Marshall1,2, Alastair J Noyce1,2 1 Preventive Neurology Unit, Wolfson Institute of Preventive Medicine, Queen Mary University of London, UK 2 Department of Neurology, Royal London Hospital, London, UK Correspondence to Stephen D Auger,...
Regarding: Nicotinic acetylcholine receptors α7 and α9 modify tobacco smoke risk for multiple sclerosis
Bycroft, C, Freeman, C, Petkova, D, . The UK Biobank resource with deep phenotyping and genomic data . Nature ; 562(7726): – .
Big data, machine learning and artificial intelligence: a neurologist’s guide
Big data, machine learning and artificial intelligence: a neurologist’s guide http://orcid.org/0000-0002-5911-7049Stephen D Auger1, http://orcid.org/0000-0002-6023-6010Benjamin M Jacobs1,2, http://orcid.org/0000-0002-2993-585XRuth Dobson1,2, Charles R Marshall1,2, Alastair J Noyce1,2 1Preventive Neurology Unit, Wolfson Institute of Preventive Medicine, Queen Mary University of London, UK 2Department of Neurology, Royal London Hospital, London, UK Correspondence to Stephen D Auger, Preventive...
Prevalence and Demographics of Multiple Sclerosis-associated Uveitis: a UK Biobank Study
Highlights • Uveitis prevalence in people with multiple sclerosis (MS) in UK Biobank was 0.51%. • The adjusted odds ratio of MS given a diagnosis of uveitis was 5.25. • Patients with both uveitis and MS were more likely to be white and female. Abstract Background Uveitis describes intraocular inflammation of the uveal tract. It may occur in the absence of a predisposing underlying condition, or may be secondary to a systemic autoimmune disease or ocular infection.
Systematic review and meta-analysis of the association between Epstein–Barr virus, multiple sclerosis and other risk factors - Benjamin M Jacobs, Gavin Giovannoni, Jack Cuzick, Ruth Dobson, 2020
Introduction Multiple sclerosis (MS) is thought to arise as the result of acquired environmental risk in a genetically susceptible population.1–4 Environmental risk factors for MS include Epstein–Barr virus (EBV) infection, smoking, obesity during adolescence, and low serum vitamin D.2 Understanding how environmental risk factors interact with each other and with genotype is crucial to developing targeted preventive strategies.
Gene-environment interactions in Multiple Sclerosis: a UK Biobank study
New Results View ORCID ProfileBenjamin Meir Jacobs, Alastair Noyce, Jonathan P Bestwick, Daniel Belete, Gavin Giovannoni, Ruth Dobson doi: https://doi.org/10.1101/2020.03.01.971739 Abstract Importance: Multiple Sclerosis (MS) is a common neuro-inflammatory disorder caused by a combination of environmental exposures and genetic risk factors. Interaction between environmental and genetic factors may impact on MS risk.
Epidemiology of Epstein-Barr Virus infection and Infectious Mononucleosis in the United Kingdom
Ashvin Kuri, View ORCID ProfileBenjamin Meir Jacobs, Nicola Vickaryous, Julia Pakpoor, Jaap Middeldorp, Gavin Giovannoni, Ruth Dobson doi: https://doi.org/10.1101/2020.01.21.20018317 Abstract Background: Epstein Barr Virus (EBV) is a ubiquitous gamma-herpesvirus with which ~95% of the healthy population is infected. EBV infection has been implicated in a range of haematological malignancies and autoimmune diseases. Delayed primary EBV infection increases the risk of subsequent complications.
Summary-data-based mendelian randomisation reveals druggable targets for multiple sclerosis
New Results View ORCID ProfileBenjamin Meir Jacobs, Thomas Taylor, Amine Awad, Gavin Giovannoni, David Baker, Alastair J Noyce, Ruth Dobson doi: https://doi.org/10.1101/2020.01.20.907451 Abstract Background: Multiple Sclerosis (MS) is a complex autoimmune disease caused by a combination of genetic and environmental factors. Translation of Genome-Wide Association Study (GWAS) findings in MS into therapeutics and effective preventive strategies has been limited to date.
BMI and low vitamin D are causal factors for multiple sclerosis
Abstract Objective To update the causal estimates for the effects of adult body mass index (BMI), childhood BMI, and vitamin D status on multiple sclerosis (MS) risk. Methods We used 2-sample Mendelian randomization to determine causal estimates. Summary statistics for SNP associations with traits of interest were obtained from the relevant consortia. Primary analyses consisted of random-effects inverse-variance-weighted meta-analysis, followed by secondary sensitivity analyses.
Systematic review and meta-analysis of the association between Epstein-Barr virus, Multiple Sclerosis, and other risk factors
Abstract Background: EBV infection is thought to play a central role in the development of Multiple Sclerosis (MS). If causal, it represents a target for interventions to reduce MS risk. Objective: To examine the evidence for interaction between EBV and other risk factors, and explore mechanisms via which EBV infection may influence MS risk.
Plasma Cell And B Cell-Targeted Treatments For Use In Advanced Multiple Sclerosis
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. Figure 1 Targeting domains for control B cell activity during multiple sclerosis. Agents target plasma cells (blue) and/or B cell lineage cells (pink) cells and/or non-B cells (transparent), which are either quiescent (Dots) or dividing (Hatch). These can be targeted either in the periphery or within the periphery and central nervous system (Grey).
Effect of Mentoring on Match Rank of Integrated Vascular Surgery Residents
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. Figure 1 Rank List Match of Respondents Abstract Introduction Mentoring relationships have been encouraged for medical students interested in surgical specialties. We investigated the role of mentoring relationships of integrated Vascular Surgery residents, while in medical school.
US Supreme Court: Interstate Independent Contractor Transportation Workers Exempt from FAA | JD Supra
Updated: May 25, 2018: JD Supra is a legal publishing service that connects experts and their content with broader audiences of professionals, journalists and associations.
Cladribine: mechanisms and mysteries in multiple sclerosis
Cladribine: mechanisms and mysteries in multiple sclerosis http://orcid.org/0000-0002-6023-6010Benjamin Meir Jacobs1, Francesca Ammoscato1, Gavin Giovannoni1,2, http://orcid.org/0000-0002-8872-8711David Baker1, Klaus Schmierer1,2 1 The Blizard Institute (Neuroscience), Queen Mary University of London, Barts and the London School of Medicine and Dentistry, London, UK 2 Emergency Care and Acute Medicine Clinical Academic Group Neuroscience, Barts Health NHS Trust, The Royal London Hospital,...
Cladribine: mechanisms and mysteries in multiple sclerosis
Objectives The aims of this manuscript were to review the evidence for the efficacy and safety of cladribine in multiple sclerosis (MS) and to review the molecular and cellular mechanisms by which cladribine acts as a disease-modifying therapy in MS. Methods This is a narrative review of the available clinical and preclinical data on the use of cladribine in MS.
No Evident Disease Activity-More Than a Risky Ambition?
Targeting no evident disease activity (NEDA) is an emerging paradigm in the treatment of relapsing multiple sclerosis (MS). The criteria for implementing this protocol, termed NEDA-3, include the absence of relapses, sustained disability progression, and magnetic resonance imaging (MRI) activity (ie, new and/or expanding lesions). Evidence suggests that achieving NEDA-3 improves prognosis in MS.
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