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Articles by Benjamin Lu
Two Takes: Should California pass Prop 45 to limit CEQA reviews for ‘essential’ projects?
The shift away from fossil fuels must also be done affordably, so the cost of the clean energy transition doesn’t fall on consumers. Unfortunately, too many clean energy projects spend years navigating environmental review, permitting and litigation, raising costs and slowing essential progress. That’s why I support Proposition 45, to help California build clean energy and other essential infrastructure faster and more affordably.
High salt exposure promotes tau hyperphosphorylation and mitochondrial reverse electron transport associated neurodegeneration in Drosophila
Abstract The pathogenesis of neurodegenerative diseases like Alzheimer’s disease (AD) is complex and involves genetic as well as environmental factors. Previous studies have implicated dietary salt as a risk factor for both AD and cognitive impairment caused by vascular factors. The molecular mechanisms by which dietary salt contributes to cognitive impairment and AD remain poorly understood.
Tau-induced mitochondrial reverse electron transport drives neurodegeneration
Keywords tau mitochondria complex I NDUFS3 phosphorylation reverse electron transport ROS NAD+/NADH ratio Alzheimer’s disease tauopathy Get full text access Log in, subscribe or purchase for full access. References 1. Parra Bravo, C. ∙ Naguib, S.A. ∙ Gan, L. Cellular and pathological functions of tau Nat. Rev. Mol. Cell Biol. 2023; 24:745-760 2. Chang, C.W. ∙ Shao, E. ∙ Mucke, L. Tau: Enabler of diverse brain disorders and target of rapidly evolving therapeutic strategies Science. 2021; 371, eabb8255 3.
The transcription factor Eomes drives a stemness program in CD4 + T cells that promotes anti-tumor immunity in response to immunotherapy
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ArticleOnline nowOpen access Affiliations & Notes 1University Toulouse, INSERM, CNRS, Infinity, Toulouse, France 2ENS, École Normale Supérieure de Lyon, Université Claude Bernard – Lyon I, University Lyon, Lyon, France 3University Toulouse, INSERM, CRCT, Toulouse, France 4Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA 5Department of Medicine (Medical Oncology) and Neurology, Yale School of Medicine, New Haven, CT, USA Article Info Publication...
By Arantxa Agesta, Chloé Ferrand, Anne-Louise Le Dorze, Cindy Peillex, Nadège Carrié, Rebecca Barascud, Arthur Palak, Lucie Esteban, Tanguy Bernal, Emeline Joulia, Céline Colacios, Romain Peroceschi, Andrea C. Pichler, Adeline Chaubet, Margot Zahm, Abdelhadi Saoudi, Benjamin Lu, Liliana E. Lucca, Ludovic Martinet, Anne Dejean, Veronique Adoue
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Cell Press
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The subfornical organ is a nucleus for gut-derived T cells that regulate behaviour - Nature
Abstract Specialized immune cells that reside in tissues orchestrate diverse biological functions by communicating with parenchymal cells1. The contribution of the innate immune compartment in the meninges and the central nervous system (CNS) is well-characterized; however, whether cells of the adaptive immune system reside in the brain and are involved in maintaining homeostasis is unclear2,3,4.
Circulating tumor-reactive KIR+CD8+ T cells suppress anti-tumor immunity in patients with melanoma - Nature Immunology
Abstract Effective anti-tumor immunity is driven by cytotoxic CD8+ T cells with specificity for tumor antigens. However, the factors that control successful tumor rejection are not well understood. Here we identify a subpopulation of CD8+ T cells that are tumor-antigen-specific and can be identified by KIR expression but paradoxically impair anti-tumor immunity in patients with melanoma.
Chemoimmunotherapy for Untreated Lung Cancer Brain Metastases: Systemic Before Local Therapy?
Brain metastases are an increasingly frequent complication in patients with cancer, occurring in over 70,000 patients in the United States annually.1 Non–small-cell lung cancer (NSCLC) is the most common cause of brain metastases, and up to 40% of patients with advanced NSCLC will develop intracranial involvement during the course of their disease.2 Despite improvements in imaging modalities to facilitate screening and early detection, as well as advances in local and systemic therapies,...
GVNG Technology, Inc. Announces Closing of New Round of Financing Led by Sentry
GVNG Technology, Inc. Announces Closing of New Round of Financing Led by Sentry LOS ANGELES, CA, USA, May 8, 2023/ EINPresswire.com/ -- GVNG Technology, Inc. (“GVNG”) a fintech company serving the philanthropic marketplace, announces that it has closed a new round of financing led by Sentry Financial, a Utah-based diversified financial services firm (“Sentry”). The GVNG software platform provides a unique seamless ability to: 1.
Shield with lion’s mane possibly made for Emperor Tewodros
A book on how Britain took one boy and piles of treasures from Ethiopia What: A shield and lion’s mane made for Emperor Tewodros, taken by the British Museum’s expert on the expedition, Richard Rivington Holmes Where: The British Museum, Great Russell St, Bloomsbury, London WC1B 3DG Provenance: Maqdala mentioned at length in acquisition notes. Shield described as possibly made for Tewodros.
A manuscript of the Miracles of Mary initially presented to Queen Victoria (OR 649)
A book on how Britain took one boy and piles of treasures from Ethiopia What: An Ethiopian manuscript dated 1717 including the Miracles of Mary as well as the miracles of Jesus Christ, St. George, St. Michael and Gabra Manfas Qedus Where: The British Library, 96 Euston Rd, London NW1 2DB Ref: OR 649 Digital version – http://www.bl.uk/manuscripts/FullDisplay.aspx?ref=Or_649 Provenance: A handwritten note on the first page reads: “Pres.
A 19th century manuscript of the Life of Alexander the Great (OR 826)
A book on how Britain took one boy and piles of treasures from Ethiopia What: A 19th century Ethiopian manuscript of the Life of Alexander the Great Where: The British Library, 96 Euston Rd, London NW1 2DB Ref: OR 826 Digital version – http://www.bl.uk/manuscripts/FullDisplay.aspx?ref=Or_826 Provenance: Stamped on first page: “Presented by the Secretary of State for India Aug.
The Prince and the Plunder
The battle The British and Indian soldiers pressed on, past crowds of thousands of Ethiopians fleeing down the mountain sides. The road twisted up between the two hills onto the wide land bridge of Islamgie. And there at the end of it, finally, was Maqdala. The soldiers could see around a hundred Ethiopian soldiers and a small group of horsemen charging backwards and forwards across the open ground at the far end of the plain, bright robes flowing behind them.
The Prince and the Plunder
A book on how Britain took one boy and piles of treasures from Ethiopia What: A processional cross taken by the British Museum’s expert on the expedition, Richard Rivington Holmes Where: The British Museum, Great Russell St, Bloomsbury, London WC1B 3DG Provenance: Maqdala referenced at length in the museum’s acquisition notes.
Royal tent made of silk damask
A book on how Britain took one boy and piles of treasures from Ethiopia What: A multi-coloured tent, given by Secretary of State for India, Sir Stafford Henry Northcote Where: The British Museum, Great Russell St, Bloomsbury, London WC1B 3DG The catalogue entry reads: “Royal tent made of silk damask”.
A 17th century Psalter with two notes linking it to Maqdala (OR 12467)
A book on how Britain took one boy and piles of treasures from Ethiopia What: An Ethiopian Psalter, finished on 6 November 1660, including a prayer for the dying, a fragment of the Miracles of the Virgin Mary containing five miracles, the Psalms and the Canticles of the Prophets of the Old and New Testaments. Two notes, one written the other inserted, link it to Maqdala.
The Prince and the Plunder
Category: Gunpowder holders What: Gunpowder holder without its lid, one of a collection of three Where: Pitt Rivers Museum, South Parks Rd, Oxford, OX1 3PP The catalogue entry reads: “Cylindrical wooden powder holder, for measuring gunpowder. The mouth is narrower than the body and the lid is missing. The wood has a similar structure and appearance of bamboo.” Accession Book Entry – G. F. LAWRENCE, 7 West Hill, Wandsworth- Jan.
A pistol, given to Tewodros by Victoria
A book on how Britain took one boy and piles of treasures from Ethiopia What: A pistol, given to Tewodros by Queen Victoria Where: The Royal Collection, Britain The , which has a picture, reads: “Percussion Revolver; octagonal blued steel barrel and body engraved with foliate scrolling; walnut grip carved with chequering; blued steel pommel cap engraved with foliate scrolls; oval escutcheon inlaid in silver and engraved with presentation inscription.” Provenance Royal Collection catalogue...
Queen Tirunesh’s clothes and jewellery
Many people who have lost a parent will know that strange, intimate moment when you go back to the empty house after the funeral and start sorting through their possessions – the old books, the faded clothes and the odd pieces of broken jewellery. Tirunesh brought her last few things with her on the road out of Maqdala. Along the route, she succumbed to a chest infection, possibly TB, and died, leaving her son Prince Alamayu alone, an orphan.
The story: Laurence Kerans, teenage captive
Of all the Europeans caught up in this story, the one who deserves our sympathy the most is a young Irishman called Laurence Kerans. He arrived in Ethiopia in the early 1860s in a burst of optimism and adventure and secured a promising job as secretary to the British Consul. But his first mission inland to deliver presents to Ethiopia’s King of Kings Tewodros II ended in disaster.
Gold disc showing crucifixion
What: Gold disc “from the cross on the altar at Magdala” showing the crucifixion, bought from Col W J Holt Where: The British Museum, Great Russell St, Bloomsbury, London WC1B 3DG Photo: The British Museum charges people to reproduce images of things in its collection, even plundered things.
A piece of the emperor’s coat
What: A 12cm-long piece of cloth cut from the Emperor’s coat on the day he died Where: The Cameronians Regimental Museum (Scottish Rifles), Mote Hill, off Muir Street, Hamilton, Lanarkshire, ML3 6BY, UK According to many accounts, British soldiers swarmed around the body of Emperor Tewodros on Magdala and cut off pieces of his clothes for souvenirs. The museum entry, which has two pictures, describes: a “small scrap of material with handwritten note” on a piece of paper.
The Prince and the Plunder
What: A necklace of silver and glass beads threaded onto blue silk cord, worn by Prince Alamayu. He was photographed and painted many times wearing it. Where: The British Museum, Great Russell St, Bloomsbury, London WC1B 3DG Photo: The British Museum charges people to reproduce images of things in its collection, even plundered things.
The Prince and the Plunder
What: The dress of Queen Tirunesh, Alamayu’s mother Where: The Victoria & Albert Museum, Cromwell Rd, Knightsbridge, London SW7 2RL Overview: Part of a collection of the queen’s clothes, jewellery and other personal possessions. It was kept aside after she died on the march back from Maqdala and given to the museum by the Secretary of State for India. On one hand, it’s tragic how little we know about Queen Tirunesh, beyond her family line and the fragments of myth.
St. Lawrence the Martyr Parish - Hamilton
The tradition returns! Get your saddle ready for the biggest Turkeys this side of Dundas, and with food and cash bar we’ll look forward to seeing the whole community come out for this fun night!
Webinar: Hainan and changing supply chains - Adapting to a new business landscape
Register here to join the webinar on June 22 In association with KPMG China, the live webinar will take place on June 22 at 10am BST/5pm CST (Beijing time). At a time when the world has been dealing with COVID-19 for years, businesses are facing greater challenges than ever before. These include anti-COVID control measures, geopolitical shifts, and Sino-US political tensions.
Music Department
Line Mountain Musical The Line Mountain School District will present the musical version of the play: “All I Really Need To Know I Learned In Kindergarten” on Thursday, Friday, and Saturday March 24th, 25th, and 26th. Each performance will begin at 7:00pm in the High School Auditorium Tickets for the show are $5 for adults and $3 for students.
The Prince and the Plunder
Out now “In this fascinating, haunting book, which takes us from a high mountain plateau in Ethiopia to Osborne on the Isle of Wight where Prince Alamayu met and charmed Queen Victoria, and all too soon to the catacombs of St George’s Chapel Windsor, Andrew Heavens tells the astonishing story of the uprooting of this lost boy.” The Daily Mail “I am very excited about this extraordinary and thrilling book and more importantly by the thought of everyone who will read it.
The Prince and the Plunder
Category: Archaeology What: Fragment of a 6th century white marble relief sculpture carved with a cross within a wreath, taken during Britain’s Abyssinian Expedition during a hit-and-run archaeological dig at Adulis in modern day Eritrea Where: The British Museum, Great Russell St, Bloomsbury, London WC1B 3DG The British Museum database entry, which has a picture, reads: “Corner of a relief sculpture panel; alabaster; carved with a double border with a leaf design; within the borders was a...
Gold steadies as markets turn defensive
GOLD REPORT A weekly market summary for gold, Jan 20-24 Sat, Jan 25, 2020 - 5:50 AM MARKETS remained on edge as painful memories of the Severe Acute Respiratory Syndrome (SARS) resurfaced over the spread of a new coronavirus. Asian equities clocked losses as investors pivoted from risk assets over growing concerns of a potential health pandemic. The outbreak has kept gold prices steady while striking a cautious tone in global markets.
Gold clocks 3-month highs over bullish technical posturing
GOLD REPORT A weekly market summary for gold, Dec 30-Jan 3 Sat, Jan 04, 2020 - 5:50 AM A DOVISH hold on US monetary policy has kept the greenback on its back foot while strengthening bullion appeal, as investors deliberate opportunity costs for the precious metal. Bullish technical posturing (chart patterns) kept gold prices positive despite renewed global risk appetites and an extended rally in the US equity market.
Gold face headwinds over robust risk appetites
GOLD REPORT A weekly market summary for gold, Nov 25-29 Sat, Nov 30, 2019 - 5:50 AM ROBUST global risk appetites have spurred US indices to record highs while imposing considerable headwinds on safe haven assets. Upbeat US economic data and global trade optimism has led to a shift in market expectations as investors turn increasingly risk-on for the current term.
Gold mixed as markets mull uncertainties of Sino-US trade talks
GOLD REPORT A weekly market summary for gold, Nov 18-22 Sat, Nov 23, 2019 - 5:50 AM GOLD prices illustrated varied signals as investors mulled over US-China trade uncertainties. Shifting market expectations over contradictory messages in the 16-month-long US-China trade spat let to choppy conditions in global markets. The safe haven asset demonstrated range-bound trades as markets balance between a strong rally in global equities and looming geopolitical risks.
Gold regains footing over downbeat economic data
GOLD REPORT A weekly market summary for gold, Nov 11-15 Sat, Nov 16, 2019 - 5:50 AM SUBDUED global growth momentum granted some respite for safe haven assets as risk appetites stay measured over disappointing economic releases. Global trade optimism over a potential resolution to the 16th month long US-China trade war has limited upside gains for the precious metal as investors pivot towards riskier assets.
Gold strengthens over global growth anxieties
GOLD REPORT A weekly market summary for gold, Oct 21-25 Sat, Oct 26, 2019 - 5:50 AM DISAPPOINTING US economic data released on Sept 19 has bolstered safe haven appeal as investors remain cautious over global recessionary fears. Persistent weakness in business investment and export figures have led to downbeat assessments for US GDP growth in Q3. A weaker global backdrop... Please log in to continue reading. gold report Gold prices
Gold supported over lacklustre economic data
GOLD REPORT A weekly market summary for gold, Oct 14-18 Sat, Oct 19, 2019 - 5:50 AM SOFTER geopolitical overtones from a preliminary US-China trade deal and signs of progress in the EU-UK divorce deal has limited upside gains for safe haven assets. Lacklustre global economic data has kept global risk appetites measured however, as investors deliberate looming downside risks.... Please log in to continue reading. gold report Gold prices
Global trade optimism dents safe haven appeal
GOLD REPORT A weekly market summary for gold, Oct 7-10 Sat, Oct 12, 2019 - 5:50 AM SIGNS of progress in US-China trade talks have led to an improvement in global risk appetites. Heightened market optimism for a temporary trade truce between the world's two largest economies dented safe haven appeal as investors pivoted towards interest-bearing assets. A positive outcome from... Please log in to continue reading. gold report
Gold supported as global central banks adopt dovish stance
GOLD REPORT A weekly market summary, Sept 16-20 Sat, Sep 21, 2019 - 5:50 AM THE US Federal Reserve has lowered the target range for its key interest rates to 1.75-2 per cent (-25bps). The Federal Reserve Open Markets Committee (FOMC) members, though voting in favour of reduced US borrowing costs, have illustrated a fundamental divide over the need for future cuts.... Please log in to continue reading. Gold prices
Gold eases bullish gains over US monetary policy uncertainties
Sat, Aug 24, 2019 - 5:50 AM HEIGHTENED market optimism on preparations for a fresh wave of economic stimulus by global central banks raised risk appetites for the current term. Growing dissent on further monetary policy easing between Fed policymakers bolstered greenback strength whilst placing a damper on gold prices.... Please log in to continue reading. gold bullion Editor's Choice
Global recessionary fears boost safe-haven appeal
Sat, Aug 17, 2019 - 5:50 AM The US 2-year to 10-year yield spread has inverted for the first time since 2007. A US yield curve inversion has preceded economic recessions historically whilst signalling a higher risk-environment in the immediate term. A delay in US tariffs on Chinese consumer electronic goods though... Please log in to continue reading. Gold prices Editor's Choice
Gold breaks US$1,500 over growing economic headwinds
GOLD REPORT A weekly market summary for gold, August 5-9 Sat, Aug 10, 2019 - 5:50 AM GOLD prices broke new ground (2019 highs) as safe haven flows surged over rising economic uncertainties. The United States has branded China as a currency manipulator after the People's Bank of China (PBOC) fixed the official midpoint reference for the Yuan above 7.00 per dollar. ... Please log in to continue reading. Gold prices bullion Editor's Choice
Gold soars as US-China trade tensions rattle markets
Sat, Aug 03, 2019 - 5:50 AM THE US Federal Reserve lowered borrowing costs by a quarter point to the target range of 2 to 2.25 per cent. Fed Chairman Jerome Powell, though indicating a dovish pivot, has refused to commit on aggressive monetary policy easing for 2H 2019. A sudden escalation in the Sino-US... Please log in to continue reading. Gold prices Editor's Choice
Gold loses some shine as investors await FOMC meeting
GOLD REPORT A weekly market summary for gold, July 22-26 Sat, Jul 27, 2019 - 5:50 AM THE precious metal eased off previously held gains amid strong US jobs data and profit-booking activities before the next Federal Open Market Committee meeting (July 30-31). Smaller rate cut expectations prompted a recovery in the US dollar whilst imposing mild headwinds for the yellow metal.... Please log in to continue reading. Phillip Futures bullion Gold prices Editor's Choice
Gold strengthens over dovish testimony by Fed chief
GOLD REPORT A weekly market summary for gold, July 8-12 Sat, Jul 13, 2019 - 5:50 AM DOVISH signals from US Federal Reserve chairman Jerome Powell bolstered bullion appeal as traders maintain bets for a quarter-basis point cut at the next Federal Open Market Committee (FOMC) meeting (July 30-31). The Fed chief spoke out on subdued economic momentum as US manufacturing Purchasing... Please log in to continue reading.
Gold maintains bullish edge on global growth worries
GOLD REPORT A weekly market summary for gold, July 1-5 Sat, Jul 06, 2019 - 5:50 AM GROWING signs of weakness in the global economy along with US protectionist trade policies have raised bullion's appeal substantially for the current term. China's Caixin Purchasing Manufacturers' Index (June 19) continues to illustrate lacklustre figures as global demand stays subdued over... If you are already a BT subscriber, please log in.
Gold notches 5-year highs over dovish signals by Fed policymakers
Sat, Jun 22, 2019 - 5:50 AM THE US Federal Reserve has signalled a strong dovish pivot on monetary policy guidance as Federal Open Market Committee officials noted lacklustre inflation and subdued economic momentum. The central bank has turned increasingly accommodative as market risks elevate over looming economic... If you are already a BT subscriber, please log in. gold Editor's Choice Most Read 1 Hour Glass co-founder Jannie Chan declared bankrupt 2 No budget for a S$100m super penthouse?
Gold shines bright as geopolitical risks threaten global growth
GOLD REPORT A weekly market summary for gold, June 10-14 Sat, Jun 15, 2019 - 5:50 AM HEIGHTENED geopolitical tensions have elevated safe haven appeal as risk sentiments stay measured over growing downside risks. US President Donald Trump has threatened to enact additional levies on Chinese imports should President Xi baulk when it comes to a meeting at the G-20 summit. A... If you are already a BT subscriber, please log in.
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Risk-off appetites bolster safe haven assets
GOLD REPORT A weekly market summary for gold, May 27-31 Sat, Jun 01, 2019 - 5:50 AM GOLD prices notched a two-week high as risk sentiments diminished over global growth concerns. President Donald Trump has vowed to impose trade tariffs on Mexican imports in response to US-Mexico migration issues. The latest salvo by the Trump administration weakened risk appetites as investors... If you are already a BT subscriber, please log in.
Gold whipsaws over strong recovery in risk assets
GOLD REPORT A weekly market summary for gold, May 13-17 Sat, May 18, 2019 - 5:50 AM AN ESCALATION in the Sino-US trade dispute kept safe haven demand firm early week as Beijing hit back with US$60 billion worth of tariffs on the United States.
Gold whipsaws over robust US economic data
GOLD REPORT A weekly market summary for gold, Apr 8-12 Sat, Apr 13, 2019 - 5:50 AM GOLD prices exhibited topsy-turvy trading conditions amid shifting market expectations on bullion appeal this week. Risk appetites diminished early week as the IMF slashed global growth forecasts downwards for the third consecutive time in six months. The impact of trade protectionism and its disruptive effect on the global supply chain unnerved traders' amid heightened downside risks for 2019.
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