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Benjamin P Kellman on Muck Rack

Benjamin P Kellman

Cambridge
As seen in: Nature, Gut Journal, PNAS, Journal of Biomedical Science, BioRxiv, The Journal of Clinical Investigation, Texas Medical Center
Bioinformatics PhD @ UCSD | Research Fellow @ Ragon Institute at MGH, MIT, and Harvard | glycan metabolism, gene expression, NGS, pathology (he/him)
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Articles

Antithrombin-binding heparan sulfate is ubiquitously expressed in epithelial cells and suppresses pancreatic tumorigenesis

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By Thomas Clausen, Ryan Weiss, Jacob Tremblay, Benjamin P Kellman
| The Journal of Clinical Investigation
Abstract 3-O-sulfation of heparan sulfate (HS) is the key determinant for binding and activation of antithrombin III (AT). This interaction is the basis of heparin treatment to prevent thrombotic events and excess coagulation. Antithrombin-binding HS (HSAT) is expressed in human tissues but is thought to be expressed in the subendothelial space, mast cells, and follicular fluid. Here, we show that HSAT is ubiquitously expressed in the basement membranes of epithelial cells in multiple tissues.
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"Elucidating Human Milk Oligosaccharide Biosynthetic Genes Through Netw" by Benjamin P Kellman, Anne Richelle et al.

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By Benjamin P Kellman
| Texas Medical Center
Keywords Glycosyltransferases, Humans, Infant, Milk, Human, Oligosaccharides, Glycomics, Polysaccharides, Biochemical networks Abstract Human Milk Oligosaccharides (HMOs) are abundant carbohydrates fundamental to infant health and development. Although these oligosaccharides were discovered more than half a century ago, their biosynthesis in the mammary gland remains largely uncharacterized.
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Boosting with adjuvanted SCB-2019 elicits superior Fcγ-receptor engagement driven by IgG3 to SARS-CoV-2 spike - npj Vaccines

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By Benjamin P Kellman, Ralf Clemens, Eduardo Sprinz, José Neto, Galit Alter, Ryan McNamara, Eveline Pipolo Milan
| Nature Verified
Abstract With the continued emergence of variants of concern, the global threat of COVID-19 persists, particularly in low- and middle-income countries with limited vaccine access. Protein-based vaccines, such as SCB-2019, can be produced on a large scale at a low cost while antigen design and adjuvant use can modulate efficacy and safety.
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