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Articles by Benjamin Weger
Genetic control and tissue specificity of transcriptomic rhythmicity
Abstract Circadian rhythms influence molecular traits in most tissues, yet genetic studies mostly treat molecular measurements as static. In particular, genetic effects on gene expression are typically investigated through expression quantitative trait locus (eQTL) studies, which ignore sampling time and therefore miss genetic effects on rhythm parameters such as amplitude and acrophase.
Feeding-regulated glycogen metabolism drives rhythmic liver protein secretion - Nature Metabolism
Abstract The liver has a key role in inter-organ communication by secreting most circulating plasma proteins. However, the mechanisms governing hepatic protein secretion remain unclear. Here we show that hepatic protein secretion follows a diurnal rhythm regulated by food intake in humans and mice.
Daylight saving time ended Sunday. Why do we change our clocks? And how does it affect our bodies?
As summer fades into autumn, most Australian states and territories will set their clocks back an hour as daylight saving time ends and standard time resumes. About one-third of the world also adjust their clocks seasonally, moving forward in spring and back in autumn (remember: spring forward; fall back). In spring, losing an hour of sleep can leave us feeling tired, groggy and out-of-sync, making it hard to shake off that lingering sleepiness in the following days.
Daylight saving time ends Sunday. Why do we change our clocks? And how does it affect our bodies?
By Meltem Weger and Benjamin Weger As summer fades into autumn, most Australian states and territories will set their clocks back an hour as daylight saving time ends and standard time resumes. About one-third of the world also adjust their clocks seasonally, moving forward in spring and back in autumn (remember: spring forward; fall back).
Daylight saving time ends Sunday. Why do we change our clocks? And how does it affect our bodies?
As summer fades into autumn, most Australian states and territories will set their clocks back an hour as daylight saving time ends and standard time resumes. About one-third of the world also adjust their clocks seasonally, moving forward in spring and back in autumn (remember: spring forward; fall back). In spring, losing an hour of sleep can leave us feeling tired, groggy and out-of-sync, making it hard to shake off that lingering sleepiness in the following days.
The hidden power of light to guide your body's sleep, energy, and digestion
Exposure to light is crucial for our physical and mental health, as this and future articles in the series will show. But the timing of that light exposure is also crucial. This tells our body to wake up in the morning, when to poo and the time of day to best focus or be alert. When we’re exposed to light also controls our body temperature, blood pressure and even chemical reactions in our body. But how does our body know when it’s time to do all this? And what’s light got to do with it?
How light tells you when to sleep, focus and poo
This article has been reviewed according to Science X's editorial process and policies . Editors have highlighted the following attributes while ensuring the content's credibility: Exposure to light is crucial for our physical and mental health, as this and future articles in the series will show. But the timing of that light exposure is also crucial. This tells our body to wake up in the morning, when to poo and the time of day to best focus or be alert.
How light tells you when to sleep, focus and poo
This is the next article in our ‘Light and health’ series, where we look at how light affects our physical and mental health in sometimes surprising ways. Read other articles in the series. Exposure to light is crucial for our physical and mental health, as this and future articles in the series will show. But the timing of that light exposure is also crucial. This tells our body to wake up in the morning, when to poo and the time of day to best focus or be alert.
Understanding circadian dynamics: current progress and future directions for chronobiology in drug discovery
Save citation to file Format: Add to My Bibliography Your saved search Name of saved search: Search terms: Frequency: Which day? Which day? Report format: Send at most: Send even when there aren't any new results Optional text in email: Create a file for external citation management software
Multiomics reveals multilevel control of renal and systemic metabolism by the renal tubular circadian clock
ResearchIn-Press PreviewNephrology Open Access | 10.1172/JCI167133 J Clin Invest. https://doi.org/10.1172/JCI167133. Copyright © 2023, Bignon et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF Abstract Circadian rhythmicity in renal function suggests rhythmic adaptations in renal metabolism.
Robust landscapes of ribosome dwell times and aminoacyl-tRNAs in response to nutrient stress in liver
Robust landscapes of ribosome dwell times and aminoacyl-tRNAs in response to nutrient stress in liver Cédric Gobet, Benjamin Dieter Weger, Julien Marquis, Eva Martin, Nagammal Neelagandan, Frédéric Gachon, Felix Naef Proceedings of the National Academy of Sciences Apr 2020, 201918145; DOI: 10.1073/pnas.1918145117
Circadian Regulation of Cochlear Sensitivity to Noise by Circulating Glucocorticoids
Highlights • Core clock gene expression in the cochlea depends on SCN input • Bmal1 is essential to maintain cochlear clock function • Differential noise sensitivity is regulated by glucocorticoid-dependent signals • Chronopharmacological approaches will optimize the treatment of hearing disorders Summary The cochlea possesses a robust circadian clock machinery that regulates auditory function. How the cochlear clock is influenced by the circadian system remains unknown.
The Mouse Microbiome Is Required for Sex-Specific Diurnal Rhythms of Gene Expression and Metabolism
Microbiota-derived metabolites and ghrelin likely drive these alterations Altered sexual maturation and GH secretion cause the damping of sexual dimorphism Most already-described changes in GF mice are hallmarks of a feminized metabolism The microbiome is required for sexual dimorphism in gene expression and metabolism The circadian clock and associated feeding rhythms have a profound impact on metabolism and the gut microbiome.
Absence of 11-keto reduction of cortisone and 11-ketotestosterone in the model organism zebrafish
Zebrafish are widely used as model organism. Their suitability for endocrine studies, drug screening and toxicity assessements depends on the extent of conservation of specific genes and biochemical pathways between zebrafish and human. Glucocorticoids consist of inactive 11-keto (cortisone and 11-dehydrocorticosterone) and active 11?-hydroxyl forms (cortisol and corticosterone).
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