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Articles by Bernard Fox
UbiVac Appoints Walter J. Urba, M.D., Ph.D., to Scientific Advisory Board
World's 1st "Dark Matter" cancer vaccine shows promise as it tripled response rate and doubled overall survival in early phase combination immunotherapy clinical trial. Former Providence Cancer Institute CMO and cancer immunotherapy pioneer Dr. Walter Urba joins UbiVac SAB to advance Dark Matter immunotherapies.
Cancer’s 'Dark Matter' Outshines Neoantigens in Landmark Debate
Cancer’s 'Dark Matter' Outshines Neoantigens in Landmark Debate First-In-Class Immune Activating Vaccine Technology A First-in-Class Cancer Vaccine Built From Human “Dark Genome” Just Beat Neoantigens In Scientific Showdown and Showed Improved Survival In Head & Neck Cancer Much progress has been made, but we still need to lighten up cancer’s dark matter to improve patients' outcomes.” — Paolo A.
Multimodal AI generates virtual population for tumor microenvironment modeling
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Keywords multimodal AI precision health tumor microenvironment digital pathology real-world evidence spatial proteomics virtual population real-world data Introduction The tumor immune microenvironment (TIME) plays a critical role in cancer progression, influencing tumor growth, invasion, metastasis, and response to cancer therapies by affecting tumor immune surveillance and evasion.1,2,3 The TIME is a highly complex spatial ecosystem consisting of cancer cells, and diverse non-malignant cell...
By Hanwen Xu, Naoto Usuyama, Chanwoo Kim, Cliff Wong, Peniel N Argaw, Racheli Ben Shimol, Angela M. Crabtree, Kevin A. Matlock, Alexandra Bartlett, Jaspreet Bagga, Yu Gu, Sheng Zhang, Tristan Naumann, Bernard Fox, Bill Wright, Ari Robicsek, Brian D. Piening, Carlo B. Bifulco, Sheng Wang, Hoifung Poon
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Cell Press
Verified
UbiVac CEO Presents Pioneering Dark-Matter Cancer Vaccine Advances at Parker Institute for Cancer Immunotherapy Workshop
UbiVac CEO Presents Pioneering Dark-Matter Cancer Vaccine Advances at Parker Institute for Cancer Immunotherapy Workshop First-In-Class Immune Activating Vaccine Technology Clinical Data Show DPV-001 Combo immunotherapy Triples Response Rates, PFS, and Doubles Overall Survival Over Standard of Care DPV-001’s strong improvements in response and survival show the power of targeting cancer’s Dark Genome. We’re excited to advance into phase II and expand this therapy to more patients.” — Bernard A.
UbiVac Showcases First 'Dark Matter' Cancer Immunotherapy Data at SITC 2025
UbiVac Showcases First 'Dark Matter' Cancer Immunotherapy Data at SITC 2025 Therapeutic Vaccines for Combination Treatment to Combat Cancer DPV-001, first cancer vaccine derived from the human dark genome, shows improved survival in head and neck cancer and reveals more than 400 new antigen targets. We now know the dark genome encodes hundreds of novel cancer antigens.
The tumor-sentinel lymph node immuno-migratome reveals CCR7⁺ dendritic cells drive response to sequenced immunoradiotherapy - Nature Communications
Abstract Surgical ablation or broad radiation of tumor-draining lymph nodes can eliminate the primary tumor response to immunotherapy, highlighting the crucial role of these nodes in mediating the primary tumor response. Here, we show that immunoradiotherapy efficacy is dependent on treatment sequence and migration of modulated dendritic cells from tumor to sentinel lymph nodes.
UbiVac CEO Participates in Cancer Vaccine Panel at SynBioBeta & Wilson Sonsini Investment Forum
UbiVac CEO Participates in Cancer Vaccine Panel at SynBioBeta & Wilson Sonsini Investment Forum Pioneering the World's 1st Dark Matter Cancer Immunotherapy AI will accelerate discovery, but the breakthrough is off‑the‑shelf vaccines targeting shared Dark‑Genome drivers—paired with nextgen immunotherapy combinations This week marks a milestone for UbiVac: we’ve documented the 1st vaccine‑induced TCR to a Dark Genome cancer antigen & the patient is cancer‑free at 10 yrs suggesting it may be...
UbiVac Presents 1st Report of In Vivo Generated T Cell Receptor (TCR) to Dark Genome-Derived Cancer’s Dark Matter
UbiVac Presents 1st Report of In Vivo Generated T Cell Receptor (TCR) to Dark Genome-Derived Cancer’s Dark Matter Pioneering the World's 1st Dark Matter Cancer Immunotherapy UbiVac’s DPV-001 induces Development of 1st in-patient generated TCR to Non-Small Cell Lung Cancer’s “Dark Matter” – Targets cancer without apparent toxicity UbiVac is thrilled to announce the first report of a TCR to Dark genome-derived "Dark Matter" that was induced in a patient, recognizes and destroys cancer, and has...
Asia’s emergence in cancer immunotherapy: challenges and opportunities
Asia’s emergence in cancer immunotherapy: challenges and opportunities Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
IL-12 drives the expression of the inhibitory receptor NKG2A on human tumor-reactive CD8 T cells - Nature Communications
Abstract Blockade of NKG2A/HLA-E interaction is a promising strategy to unleash the anti-tumor response. Yet the role of NKG2A+ CD8 T cells in the anti-tumor response and the regulation of NKG2A expression on human tumor-infiltrating T cells are still poorly understood.
Jeffrey S Weber, MD, PhD (1952-2024): in memoriam to discovery, friendship and family
Cytokine Vaccine Tumor infiltrating lymphocyte - TIL Adjuvant Immunotherapy Jeffrey S Weber’s passing on 18 August 2024 brought forth a wave of emotions and fond memories for a colleague considered to be one of the major forces in the advancement of tumor immunology and immunotherapy. Known for his keen wit, sharp insights and gracious personality, Jeff pioneered novel science, led practice-changing clinical trials and mentored the next generation of investigators.
Lymphatic-preserving treatment sequencing with immune checkpoint inhibition unleashes cDC1-dependent antitumor immunity in HNSCC - Nature Communications
Abstract Despite the promise of immune checkpoint inhibition (ICI), therapeutic responses remain limited. This raises the possibility that standard of care treatments delivered in concert may compromise the tumor response. To address this, we employ tobacco-signature head and neck squamous cell carcinoma murine models in which we map tumor-draining lymphatics and develop models for regional lymphablation with surgery or radiation.
UbiVac Announces Preliminary Immunological Data from 1st-In-Human Trial of DPV-001 Immunotherapy Trio for Advanced HNSCC
First-In-Class Immune Activating Vaccine Technology Data from Clinical Trial of DPV-001 & Anti-PD-1 +/- anti-GITR for Head & Neck Squamous Cell Cancer (HNSCC) Presented at American Association for Cancer Research UbiVac is excited to be collaborating with Providence and Incyte, a leader in immuno-oncology, to investigate whether this strategy can augment tumor destructive immune responses in patients” — Bernard A.
SARS-CoV-2 antibodies detected in human breast milk post-vaccination
ABSTRACT Importance The SARS-CoV-2 pandemic has infected over a hundred million people worldwide, with almost 2.5 million deaths at the date of this publication. In the United States, Pfizer-BioNTech and Moderna vaccines were first administered to the public starting in December 2020, and no lactating women were included in the initial trials of safety/efficacy.
The British Standard for (European Conformity[CE] Marked) Anti‐D: Its rarely discussed but important role in quantitating anti‐D in patient plasma
LETTER TO THE EDITOR Bernard Fox Corresponding Author E-mail address: bernard.fox@nibsc.org https://orcid.org/0000-0001-6362-5196 Division of Biotherapeutics, National Institute for Biological Standards and Control, Hertfordshire, UK Correspondence Bernard Fox, Division of Biotherapeutics, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, UK.
A WHO Reference Reagent for lupus (anti-dsDNA) antibodies: international collaborative study to evaluate a candidate preparation
Systemic lupus erythematosus A WHO Reference Reagent for lupus (anti-dsDNA) antibodies: international collaborative study to evaluate a candidate preparation Bernard J Fox1, Jason Hockley2, Peter Rigsby2, Carl Dolman1, Pier Luigi Meroni3, Johan Rönnelid4 1 Division of Biotherapeutics, National Institute for Biological Standards and Control, Potters Bar, UK 2 Division of Analytical & Biological Sciences, National Institute for Biological Standards and Control, Potters Bar, UK 3...
A WHO Reference Reagent for lupus (anti-dsDNA) antibodies: international collaborative study to evaluate a candidate preparation
Systemic lupus erythematosus A WHO Reference Reagent for lupus (anti-dsDNA) antibodies: international collaborative study to evaluate a candidate preparation Bernard J Fox1, Jason Hockley2, Peter Rigsby2, Carl Dolman1, Pier Luigi Meroni3, Johan Rönnelid4 1Division of Biotherapeutics, National Institute for Biological Standards and Control, Potters Bar, UK 2Division of Analytical & Biological Sciences, National Institute for Biological Standards and Control, Potters Bar, UK 3Immunorheumatology...
Bernard Fox, Dr. Bombay on 'Bewitched,' dies at 89 - Valley Morning Star : Entertainment
The Welsh-born actor's extensive, wide-ranging film and TV credits included "The Mummy," ''Herbie Goes to Monte Carlo," ''The Dick Van Dyke Show," ''McHale's Navy" and "Columbo." He appeared in both 1997's "Titanic," playing Col. Archibald Gracie, and in a 1958 movie about the ship tragedy, "A Night to Remember." He had an uncredited role in the latter, playing a sailor who delivers the line, "Iceberg's dead ahead, sir!" according to his family.
Bernard Fox, Dr. Bombay on 'Bewitched,' dies at 89 - starherald.com: National
Thank you for reading our articles on starherald.com. To continue reading articles, you will need to become a subscriber or log in if you are a subscriber. For information about subscribing, click on Subscribe and follow the instructions. You can also contact our circulation department, 308-632-9010, between the hours of 8 a.m. to 5 p.m. (MT) Monday - Friday, or email circ@starherald.com. If you don’t wish to subscribe, please visit us again to read more articles.
Bernard Fox, Dr. Bombay on 'Bewitched,' dies at 89 - El Nuevo Heraldo: Tv
The Welsh-born actor's extensive, wide-ranging film and TV credits included "The Mummy," ''Herbie Goes to Monte Carlo," ''The Dick Van Dyke Show," ''McHale's Navy" and "Columbo." He appeared in both 1997's "Titanic," playing Col. Archibald Gracie, and in a 1958 movie about the ship tragedy, "A Night to Remember." He had an uncredited role in the latter, playing a sailor who delivers the line, "Iceberg's dead ahead, sir!" according to his family.
Bernard Fox, Dr. Bombay on 'Bewitched,' dies at 89 - HeraldCourier.com: Entertainment
The Welsh-born actor's extensive, wide-ranging film and TV credits included "The Mummy," ''Herbie Goes to Monte Carlo," ''The Dyke Van Dyke Show," ''McHale's Navy" and "Columbo." He appeared in both 1997's "Titanic," playing Col. Archibald Gracie, and in a 1958 movie about the ship tragedy, "A Night to Remember." He had an uncredited role in the latter, playing a sailor who delivers the line, "Iceberg's dead ahead, sir!" according to his family.
Bernard Fox, Dr. Bombay on 'Bewitched,' dies at 89 - Brownsville Herald: Entertainment
The Welsh-born actor's extensive, wide-ranging film and TV credits included "The Mummy," ''Herbie Goes to Monte Carlo," ''The Dick Van Dyke Show," ''McHale's Navy" and "Columbo." He appeared in both 1997's "Titanic," playing Col. Archibald Gracie, and in a 1958 movie about the ship tragedy, "A Night to Remember." He had an uncredited role in the latter, playing a sailor who delivers the line, "Iceberg's dead ahead, sir!" according to his family.
Bernard Fox, Dr. Bombay on 'Bewitched,' dies at 89 - Richmond Times-Dispatch: Ap
The Welsh-born actor's extensive, wide-ranging film and TV credits included "The Mummy," ''Herbie Goes to Monte Carlo," ''The Dick Van Dyke Show," ''McHale's Navy" and "Columbo." He appeared in both 1997's "Titanic," playing Col. Archibald Gracie, and in a 1958 movie about the ship tragedy, "A Night to Remember." He had an uncredited role in the latter, playing a sailor who delivers the line, "Iceberg's dead ahead, sir!" according to his family.
Bernard Fox, Dr. Bombay on 'Bewitched,' dies at 89
Harlan Boll, a spokesman for Fox's family, said he died Wednesday of heart failure at a Los Angeles-area hospital. The Welsh-born actor's extensive, wide-ranging film and TV credits included "The Mummy," ''Herbie Goes to Monte Carlo," ''The Dick Van Dyke Show," ''McHale's Navy" and "Columbo." He appeared in both 1997's "Titanic," playing Col.
Bernard Fox, Dr. Bombay on 'Bewitched,' dies at 89 - Roanoke Times: Wire Headlines
The Welsh-born actor's extensive, wide-ranging film and TV credits included "The Mummy," ''Herbie Goes to Monte Carlo," ''The Dick Van Dyke Show," ''McHale's Navy" and "Columbo." He appeared in both 1997's "Titanic," playing Col. Archibald Gracie, and in a 1958 movie about the ship tragedy, "A Night to Remember." He had an uncredited role in the latter, playing a sailor who delivers the line, "Iceberg's dead ahead, sir!" according to his family.
Bernard Fox, Dr. Bombay on 'Bewitched,' dies at 89 - Dothan Eagle: Entertainment
The Welsh-born actor's extensive, wide-ranging film and TV credits included "The Mummy," ''Herbie Goes to Monte Carlo," ''The Dick Van Dyke Show," ''McHale's Navy" and "Columbo." He appeared in both 1997's "Titanic," playing Col. Archibald Gracie, and in a 1958 movie about the ship tragedy, "A Night to Remember." He had an uncredited role in the latter, playing a sailor who delivers the line, "Iceberg's dead ahead, sir!" according to his family.
Bernard Fox, Dr. Bombay on 'Bewitched,' dies at 89 - Appeal-Democrat: Local Entertainment
MICHAEL DWYER Bernard Fox, Dr. Bombay on 'Bewitched,' dies at 89 FILE - In this June 15, 2005 file photo, director of the 1960s sitcom 'Bewitched', Willaim Asher, seated, shares the stage with characters from the show, standing from left, Bernard Fox, Casey Rogers and Erin Murphy, in Salem, Mass., during the unveiling of a statue, left, depicting Samantha Stevens, the fictional witch played by Elizabeth Montgomery in the series.
Bernard Fox, Dr. Bombay on 'Bewitched,' dies at 89 - El Nuevo Heraldo: Tv
The Welsh-born actor's extensive, wide-ranging film and TV credits included "The Mummy," ''Herbie Goes to Monte Carlo," ''The Dyke Van Dyke Show," ''McHale's Navy" and "Columbo." He appeared in both 1997's "Titanic," playing Col. Archibald Gracie, and in a 1958 movie about the ship tragedy, "A Night to Remember." He had an uncredited role in the latter, playing a sailor who delivers the line, "Iceberg's dead ahead, sir!" according to his family.
Bernard Fox, Dr. Bombay on 'Bewitched,' dies at 89 - TheDerrick.com: Entertainment
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Bernard Fox, Dr. Bombay on 'Bewitched,' dies at 89 - HeraldCourier.com: News
Posted: Wednesday, December 14, 2016 9:53 pm | Updated: 9:53 pm, Wed Dec 14, 2016. Bernard Fox, Dr. Bombay on 'Bewitched,' dies at 89 LOS ANGELES (AP) — Bernard Fox, the mustachioed actor known to TV viewers as Dr. Bombay on "Bewitched" and Col. Crittendon on "Hogan's Heroes," has died. He was 89. Harlan Boll, a spokesman for Fox's family, said he died Wednesday of heart failure at a Los Angeles-area hospital. An online service is needed to view this article in its entirety.
Bernard Fox, Dr. Bombay on 'Bewitched,' dies at 89 - Appeal-Democrat: National News
Posted: Wednesday, December 14, 2016 3:46 pm Bernard Fox, Dr. Bombay on 'Bewitched,' dies at 89 Associated Press | LOS ANGELES (AP) — A family spokesman says that Bernard Fox, known to TV viewers as Dr. Bombay on "Bewitched" and Col. Crittendon on "Hogan's Heroes," has died. He was 89. Spokesman Harlan Boll said the actor died Wednesday of heart failure at a Los Angeles-area hospital. An online service is needed to view this article in its entirety.
Bernard Fox, Dr. Bombay on 'Bewitched,' dies at 89 - starherald.com: Nation/World
Thank you for reading our articles on starherald.com. To continue reading articles, you will need to become a subscriber or log in if you are a subscriber. For information about subscribing, click on Subscribe and follow the instructions. You can also contact our circulation department, 308-632-9010, between the hours of 8 a.m. to 5 p.m. (MT) Monday - Friday, or email circ@starherald.com. If you don’t wish to subscribe, please visit us again to read more articles.
Bernard Fox, Dr. Bombay on 'Bewitched,' dies at 89 - Porterville Recorder: State News
Posted: Wednesday, December 14, 2016 4:22 pm | Updated: 6:02 pm, Wed Dec 14, 2016. Bernard Fox, Dr. Bombay on 'Bewitched,' dies at 89 Associated Press | LOS ANGELES (AP) — Bernard Fox, the mustachioed actor known to TV viewers as Dr. Bombay on "Bewitched" and Col. Crittendon on "Hogan's Heroes," has died. He was 89. Harlan Boll, a spokesman for Fox's family, said he died Wednesday of heart failure at a Los Angeles-area hospital. An online service is needed to view this article in its entirety.
Bernard Fox, Dr. Bombay on 'Bewitched,' dies at 89 - Porterville Recorder: State News
MICHAEL DWYER Bernard Fox, Dr. Bombay on 'Bewitched,' dies at 89 FILE - In this June 15, 2005 file photo, director of the 1960s sitcom 'Bewitched', Willaim Asher, seated, shares the stage with characters from the show, standing from left, Bernard Fox, Casey Rogers and Erin Murphy, in Salem, Mass., during the unveiling of a statue, left, depicting Samantha Stevens, the fictional witch played by Elizabeth Montgomery in the series.
Bernard Fox, Dr. Bombay on 'Bewitched,' dies at 89 - WacoTrib.com: Headlines
LOS ANGELES (AP) — A family spokesman says that Bernard Fox, known to TV viewers as Dr. Bombay on "Bewitched" and Col. Crittendon on "Hogan's Heroes," has died. He was 89. Spokesman Harlan Boll said the actor died Wednesday of heart failure at a Los Angeles-area hospital.
Bernard Fox, Dr. Bombay on 'Bewitched,' dies at 89
LOS ANGELES (AP) — A family spokesman says that Bernard Fox, known to TV viewers as Dr. Bombay on "Bewitched" and Col. Crittendon on "Hogan's Heroes," has died. He was 89. Spokesman Harlan Boll said the actor died Wednesday of heart failure at a Los Angeles-area hospital.
Countdown to GI Immunotherapy
Immunotherapy: On the Frontier of Cure John L. Marshall, MD: This is John Marshall, director of the Ruesch Center for the Cure of Gastrointestinal (GI) Cancers at Georgetown's Lombardi Comprehensive Cancer Center in Washington, DC. Welcome to the 2014 Ruesch Center Symposium, "Fighting a Smarter War Against Cancer." Every year we try to bring together thought leaders to challenge the barriers that are keeping us from reaching our goal of curing cancer. That is what our patients want.
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