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Articles by Bernice Lo
GPR15-guided CD8 + T regulatory cells control intestinal inflammation
Abstract Inflammatory bowel disease (IBD) causes chronic suffering from gastrointestinal inflammation and dysfunction that can progress to colon cancer1,2. The disease prevalence is increasing and there is an urgent need to better understand its pathogenic mechanisms to improve treatment.
Precision medicine in monogenic inflammatory bowel disease: proposed mIBD REPORT standards - Nature Reviews Gastroenterology & Hepatology
Abstract Owing to advances in genomics that enable differentiation of molecular aetiologies, patients with monogenic inflammatory bowel disease (mIBD) potentially have access to genotype-guided precision medicine. In this Expert Recommendation, we review the therapeutic research landscape of mIBD, the reported response to therapies, the medication-related risks and systematic bias in reporting.
Navigating the alphabet soup of immunodeficiency
The acronyms in Clinical Immunology are gradually increasing because of the identification of novel immune disorders and the expansion of our understanding of immunopathogenesis. The term primary immunodeficiency (PID) is now being superseded by an inborn error of immunity (IEI). This change is partly driven by the recognition that such disorders may not only involve impaired immune response to infection, but also autoimmunity, lymphocytic infiltration, and malignancy.
Intern Confidential: 3 Months of Blood, Sweat, and Work Experience at New Relic
Did you know that 19 interns from schools all over the country spent their summers working with and contributing to a wide variety of New Relic teams: engineering, marketing, sales—even our legal team? Now, as the summer winds down, our interns are wrapping up their projects here at New Relic and returning to school or applying for new positions. Before they headed out the door, we sat down with two of our San Francisco interns to ask about their experiences and what they learned this year.
Meet the New Relic Portland Interns
Last week we profiled the interns working in our San Francisco headquarters. Now we’re heading north to pick the (ridiculously intelligent) brains of the engineering interns in our Portland, Ore., office. They’ve been spending the summer working with lines of code, learning new technologies, and paving the way for their tech careers. Read their stories below. Eric Wang: Engineering Eric is pursuing a double major in computer science and studio art at Swarthmore College in Pennsylvania.
Meet the New Relic San Francisco Interns
Summers here at New Relic usually come with a handful of new, young faces wandering through our offices. This year is the third year of our summer internship program, and we are excited to welcome 20 interns from around the country to work in a variety of departments throughout our San Francisco and Portland offices. This week, we take a look at the interns working in our San Francisco headquarters.
Community Spotlight: New Relic Office Assistant Andrew Hurwitz
Andrew Hurwitz is one of the happiest and hardest working people you will ever meet. He has worked as our San Francisco office assistant for over a year now, assisting in the café, restocking supplies, delivering packages, and tidying up around our SF headquarters. Andrew Hurwitz We found Andrew through his agency, The Arc San Francisco, which serves adults with intellectual and/or developmental disabilities and helps them to live full and integrated lives in the community.
Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy
Typically in translational research, a discovery in cell or molecular biology is later exploited to improve patient care. Occasionally, information flows in the opposite direction. Lo et al. found that patients with an autoimmune disorder caused by deficiency of a protein called LRBA responded dramatically to the drug abatacept (see the Perspective by Sansom). Abatacept contains a segment of a potent inhibitory immune receptor, CTLA4.
Meet the New Relic Sales and Marketing Interns
Ready to meet another group of eager, young data nerds? In an earlier post, we profiled our eight engineering interns, almost all based in our Portland office. Today we’ll introduce you to the remaining business interns who are working with our sales and marketing teams in New Relic’s San Francisco Headquarters. Even though they’re all still in school, each brings his or her own unique skills, experience, and talents to the job.
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