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Articles by Binbin Ding
Nanomaterials Enable Spatiotemporally Controlled Ultrasound-Triggered Pyroptosis for Cancer Immunotherapy
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement Data sharing not applicable to this article as no datasets were generated or analyzed during the current study. References 1, “Cancer Immunotherapy Comes of Age,” Science 355 (2017): 1220–1222, https://doi.org/10.1126/science.355.6330.1220.
Albumin Nanoparticles Co-Loaded with Dual Drugs for Enhanced Ferroptosis-Based Cancer Therapy through Modulating Cholesterol Metabolism
ACS Nano Cite this: ACS Nano 2026, XXXX, XXX Click to copy citationCitation copied! . This publication is licensed under CC-BY-NC-ND 4.0 . You are free to share (copy and redistribute) this article in any medium or format within the parameters below: Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Non-Commercial (NC): Only non-commercial uses of the work are permitted.
Coronaviral nsp6 hijacks ERAD machinery to facilitate lipolysis and supply membrane components for DMV growth - Nature Communications
Abstract The positive-strand RNA ( + RNA) viruses extensively remodel cellular endomembranes to facilitate viral replication, with coronaviruses forming a specialized viral replication organelle (RO) known as double-membrane vesicles (DMVs). These DMVs serve as platforms for viral replication and shield viral RNA from host immune recognition. However, the biogenesis, structural organization, and physiological properties of DMVs remain poorly understood.
Sub‐1 nm CuO‐Phosphomolybdic Acid Nanosheets for Ultrasound‐Controlled Pyroptosis Activation and Tumor Immunotherapy
Conflict of Interests The authors declare no conflict of interest. Supporting Information Filename Description anie202508544-sup-0001-SuppMat.docx9.5 MB Supporting Information References 1, , , , Nat. Rev. Drug Discov. 2018, 17, 783–784. 2, , , J. Am. Chem. Soc. 2024, 146, 10217–10233. 3, , , , , , , , , , , , , , , Biomaterials 2024, 305, 122463. 4, , Cancer Cell 2023, 41, 421–433. 5, , , , , , , , , , , , Proc. Natl. Acad. Sci. 2023, 120, e2304966120. 6, , , , , , , , , , , , , J. Am. Chem. Soc.
Multi‐Path ROS Storm and Immune Activation via Sulfur Vacancy‐Optimized ZnIn2S4 Nanosheets for Piezocatalytic Tumor Therapy
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
A Bionic Textile Sensory System for Humanoid Robots Capable of Intelligent Texture Recognition
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adma202417729-sup-0001-SuppMat.docx22.7 MB Supporting Information adma202417729-sup-0002-MovieS1.mp435.2 MB Supplemental Movie 1 adma202417729-sup-0003-MovieS2.mp416.4 MB Supplemental Movie 2 adma202417729-sup-0004-MovieS3.mp415.9 MB Supplemental Movie 3 References 1, , , IEEE/CAA J. Autom. Sin. 2024, 11, 301.
Gallium‐Magnesium Layered Double Hydroxide for Elevated Tumor Immunotherapy Through Multi‐Network Synergistic Regulation
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adma202501256-sup-0001-SuppMat.docx31.4 MB Supporting Information References 1, , , Nat. Rev. Immunol. 2020, 20, 651. 2a) , , , , Cell 2021, 184, 5309; b) , , Cancer Cell 2023, 41, 374. 3a) , , , , , , Nat. Rev. Cancer 2021, 21, 701; b) , , , , Exploration 2023, 3, 20220001. 4a) , , , , , , , , , , , , , , , , , , , , , , , Nature 2024, 630, 437; b) , , , , , , , , , Adv. Funct.l Mater.
"QA-SNARE Syntaxin 18 Mediates Lipid Droplet Fusion with SNAP23 and SEC" by Yuhui Fu, Binbin Ding et al.
Abstract Lipid droplets (LDs) are dynamic lipid storage organelles that can sense and respond to changes in systemic energy balance. The size and number of LDs are controlled by complex and delicate mechanisms, among which, whether and which SNARE proteins mediate LD fusion, and the mechanisms governing this process remain poorly understood. Here we identified a SNARE complex, syntaxin 18 (STX18)-SNAP23-SEC22B, that is recruited to LDs to mediate LD fusion.
Silver Molybdate Nanoparticles for Enhanced Tumor Immunotherapy through Pyroptosis Conversion and Ferroptosis Induction
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Filename Description anie202501530-s1-support_information.pdf1.9 MB Supplementary
Silver Molybdate Nanoparticles for Enhanced Tumor Immunotherapy through Pyroptosis Conversion and Ferroptosis Induction
Conflict of Interests The authors declare no conflict of interest. Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Accelerating Tumor Immunotherapy Through a Synergistic Strategy of Increasing Throttle and Relaxing Brake
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Empirical Research on the Impact of Technological Innovation on New Energy Vehicle Sales
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Multi‐Enzyme Mimetic MoCu Dual‐Atom Nanozyme Triggering Oxidative Stress Cascade Amplification for High‐Efficiency Synergistic Cancer Therapy
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Dual Starvations Induce Pyroptosis for Orthotopic Pancreatic Cancer Therapy through Simultaneous Deprivation of Glucose and Glutamine
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Am. Chem. Soc. 2024, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
Dual Starvations Induce Pyroptosis for Orthotopic Pancreatic Cancer Therapy through Simultaneous Deprivation of Glucose and Glutamine
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Am. Chem. Soc.
An Enzyme‐Engineered Coppery Nanozyme for High‐Efficiency Mild Photothermal/Chemodynamic/Starvation Therapy Through Self‐Reinforcing Cancer Energy Metabolism Regulation
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm202313853-sup-0001-SuppMat.pdf3.1 MB Supporting Information References 1a) , , , , Chem. Soc. Rev. 2019, 48, 2053; b) , , Chem. Soc. Rev. 2021, 50, 1111. 2a) , , , , , , Angew. Chem., Int. Ed. 2019, 58, 1057; b) , , , , , , , , , , , , , , , , , Adv. Funct. Mater. 2020, 30, 1909391. 3a) , , , , , , , , J. Am. Chem. Soc. 2020, 142, 5649; b) , , , , Adv. Drug Delivery Rev. 2022, 185, 114311.
Soil salinity monitoring model based on the synergistic construction of ground‐UAV‐satellite data
REFERENCES , & (2019). Mapping soil salinity in arid and semi-arid regions using Landsat 8 OLI satellite data. Remote Sensing Applications: Society and Environment, 13, 415–425. , , , , , , , & (2020). Long-term monitoring of soil salinity in a semi-arid environment of Turkey. Catena, 193(104), 614. , , & (2014). Assessing soil salinity using soil salinity and vegetation indices derived from IKONOS high-spatial resolution imageries: Applications in a date palm dominated region. Geoderma, 230, 1–8.
Large‐area growth of monolayer MoS2 by using atmospheric‐pressure chemical vapor deposition with nucleation controlling process
Supporting Information Filename Description sia7264-sup-0001-Supplementary materials.docWord document, 1.2 MB Figure S1. Schematic diagram of self-organized APCVD. Figure S2. Schematic diagram of MoS2/Al2O3 after optimization with different parameters. Temperature difference between TII and TIII a), nucleation temperature b), distances from MoO3 to Al2O3 c) and heating rate d). REFERENCES 1, , , et al. High field-effect performance and intrinsic scattering in the two-dimensional MoS2 semiconductors.
Tumor Microenvironment‐Activated Nanocomposite for Self‐Amplifying Chemodynamic/Starvation Therapy Enhanced IDO‐Blockade Tumor Immunotherapy
1 Introduction With the emergence of nanotherapeutics, the ever-increasing focus consists of the external noninvasive and accurate oncotherapy.[1] Chemodynamic therapy (CDT), which involves the use of various transition metal ions to catalyze the endogenous hydrogen peroxide (H2O2) through Fenton or Fenton-like reactions to generate highly cytotoxic hydroxyl radicals (•OH) to eliminate tumor cells, is attracting considerable attention owing to its high therapeutic performance in deep-tissue...
Tumor Microenvironment‐Activated Nanocomposite for Self‐Amplifying Chemodynamic/Starvation Therapy Enhanced IDO‐Blockade Tumor Immunotherapy
1 Introduction With the emergence of nanotherapeutics, the ever-increasing focus consists of the external noninvasive and accurate oncotherapy.[1] Chemodynamic therapy (CDT), which involves the use of various transition metal ions to catalyze the endogenous hydrogen peroxide (H2O2) through Fenton or Fenton-like reactions to generate highly cytotoxic hydroxyl radicals (•OH) to eliminate tumor cells, is attracting considerable attention owing to its high therapeutic performance in deep-tissue...
Effects of Skeleton Structure of Mesoporous Silica Nanoadjuvants on Cancer Immunotherapy
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description smll202305567-sup-0001-SuppMat.pdf2.1 MB Supporting Information References 1, , , , , , Vaccine 2019, 37, 3167. 2a) , , , Immunity 2010, 33, 492; b) , , , , , , Trends Biotechnol. 2019, 37, 373. 3, , , , , , , , , , Asian J. Pharm. Sci. 2022, 17, 583. 4a) , , , , , ACS Nano 2021, 15, 12567; b) , , , , , J. Control. Release 2016, 238, 58; c) , , , Adv. Mater. 2012, 24, 3724; d) , , , , , , , Angew.
Sodium Bicarbonate Nanoparticles for Amplified Cancer Immunotherapy by Inducing Pyroptosis and Regulating Lactic Acid Metabolism
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Land Cover Extraction in the Typical Black Soil Region of Northeast China Using High-Resolution Remote Sensing Imagery
Open AccessArticle by 1, 1,*,†, 2,*,† and 1 1 College of Civil Engineering and Architecture, Jishou University, Zhangjiajie 427000, China 2 State Key Laboratory of Resources and Environmental Information System, Institute of Geographical Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China * Authors to whom correspondence should be addressed. † These authors contributed equally to this work.
ZIF‐8 Nanoparticles Evoke Pyroptosis for High‐Efficiency Cancer Immunotherapy
Graphical Abstract The intrinsic therapeutic effect and immunogenicity of zeolitic imidazolate framework-8 (ZIF-8) nanoparticles were studied. The nanoparticles can intrinsically induce pyroptosis accompanied by necrosis and immunogenic cell death to further activate antitumor immunity and reprogram the immunosuppressive tumor microenvironment, thus realizing high-efficiency immunotherapy and tumor growth inhibition.
Bioinspired Nanocatalysts as Hydrogen Peroxide Homeostasis Regulators for Tumor-Specific Synergistic Therapy
Bioinspired Nanocatalysts as Hydrogen Peroxide Homeostasis Regulators for Tumor-Specific Synergistic Therapy Tailored to special tumor microenvironment (TME), chemodynamic therapy (CDT) has been introduced to generate hydroxyl radicals (•OH) primarily for tumor via the Fenton and Fenton-like reactions. However, the deficient hydrogen peroxide (H2O2) level and low reaction efficiency extremely limit the development of CDT, which attracts tremendous efforts to investigate.
Understanding Structure-Function Relationships of Nanoadjuvants for Enhanced Cancer Vaccine Efficacy
Review Jia Tan, Jia Tan State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China University of Science and Technology of China, Hefei, 230026 China Search for more papers by this author Binbin Ding, Corresponding Author Binbin Ding bbding@ciac.ac.cn State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China...
Biodegradable Upconversion Nanoparticles Induce Pyroptosis for Cancer Immunotherapy
Pyroptosis, which is a mode of programmed cell death, has proven effective for cancer therapy. However, efficient pyroptosis inducers for tumor treatment are limited. This study proposes biodegradable K3ZrF7:Yb/Er upconversion nanoparticles (ZrNPs) as pyroptosis inducers for cancer immunotherapy. ZrNPs, which are similar to ion reservoirs, can be dissolved inside cancer cells and release high amounts of K+ and [ZrF7]3– ions, resulting a surge in intracellular osmolarity and homeostasis imbalance.
Manganese Oxide Nanomaterials Boost Cancer Immunotherapy
Manganese Oxide Nanomaterials Boost Cancer Immunotherapy Immunotherapy, a strategy that leverages the host immune function to fight against cancer, plays an increasingly important role in clinical tumor therapy. In spite of the great success achieved in not only clinic treatment but also basic research, cancer immunotherapy still faces many huge challenges.
NIR-triggered Biodegradable MOF-coated Upconversion Nanoparticles for Synergetic Chemodynamic/Photodynamic Therapy with Enhanced Efficacy
NIR-triggered Biodegradable MOF-coated Upconversion Nanoparticles for Synergetic Chemodynamic/Photodynamic Therapy with Enhanced Efficacy The generation of reactive oxygen species (ROS) is often limited by the overexpression of glutathione (GSH) in the tumor microenvironment (TME) and the penetration depth of visible light.
MnOx Nanospikes as Nanoadjuvants and Immunogenic Cell Death Drugs with Enhanced Antitumor Immunity and Antimetastatic Effect
Communication Dr. Fan Jiang State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China University of Science and Technology of China, Hefei, 230026 China Search for more papers by this author Dr. Yajie Zhao State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China University of Science and Technology of...
One-pot synthesis of SiO2-coated Gd2(WO4)3: Yb3+/Ho3+ nanoparticles for simultaneous multi-imaging, temperature sensing and tumor inhibition
One-pot synthesis of SiO2-coated Gd2(WO4)3: Yb3+/Ho3+ nanoparticles for simultaneous multi-imaging, temperature sensing and tumor inhibition Guofeng Liu, Yeqing Chen, Mochen Jia, zhen sun, Binbin Ding, Shuai Shao, Fan Jiang, Zuoling Fu, Ping'an Ma and Jun Lin Abstract The rare earth ion-doped fluorides upconversion nanoparticles (UCNPs), appearing as a novel leaguer of probes and drug carriers, exhibit superior promise for bio-applications in diagnose and treatment on account of strong...
Zinc deficiency: An unexpected trigger for autophagy
Zinc deficiency: An unexpected trigger for autophagy Binbin Ding and Qing Zhong1 From the Center for Autophagy Research, Department of Internal Medicine, Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 ?1 To whom correspondence should be addressed: Tel.: 214-648-3086; Fax: 214-648-0284; E-mail: qing.zhong{at}utsouthwestern.edu. Edited by George N.
The Matrix Protein of Human Parainfluenza Virus Type 3 Induces Mitophagy that Suppresses Interferon Responses
Publication HistoryPublished: April 12, 2017Accepted: March 6, 2017; Received in revised form: January 3, 2017; Received: June 30, 2016;
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