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Articles by Borja Ocón
Coordinated transcriptional networks program organelle expansion and metabolic flows for high endothelial morphology and function
Keywords high endothelial cells goblet cells adaptive ER responses inter-organelle metabolic flux sulfated mucin specialization lymphocyte trafficking Get full text access Log in, subscribe or purchase for full access. References 1. Palm, W. ∙ Thompson, C.B. Nutrient acquisition strategies of mammalian cells Nature. 2017; 546:234-242 2. Buck, M.D. ∙ Sowell, R.T. ∙ Kaech, S.M. ... Metabolic Instruction of Immunity Cell. 2017; 169:570-586 3. Chapman, N.M. ∙ Chi, H.
GPR15-guided CD8 + T regulatory cells control intestinal inflammation
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Abstract Inflammatory bowel disease (IBD) causes chronic suffering from gastrointestinal inflammation and dysfunction that can progress to colon cancer1,2. The disease prevalence is increasing and there is an urgent need to better understand its pathogenic mechanisms to improve treatment.
By Jing Cui, Zuojia Chen, Jia Nie, maria zhu, CHEN Xiang, Samuel D. Chauvin, Wiem Lassoued, Can Liu, Kartika Padhan, Jian Song, Joy A. Pai, Borja Ocón, Yifan Yang, Yikun Yao, Ann Park, Justin Q. Gabrielski, Lixin Zheng, Ping Du Jiang, Yu Zhang, Huie Jing, Leilei Xu, Vicky Chen, Brent A. Calabresi, Stefania Pittaluga, David E Kleiner, Clifton L. Dalgard, Sinan Sari, Salim Can, Elif Karakoc-Aydiner, Safa Baris, Baran Erman, Jocelyn A. Silvester, Gwen Saccocia, Eman K. Buhamrah, Khaled H. Husain, Zahra Chavoshzadeh, Nima Rezaei, Ali İşlek, Hasan Baş, Fatma Dereli Devrez, Rafah Mackeh, Ivan Fuss, Daniel S. Reich, Shania Bailey, Houssein Abdul Sater, JAMES GULLEY, Juraj Kabat, Margery G. Smelkinson, Sundar Ganesan, Zhenghao Chen, Peter C Grayson, Neelam Redekar, Justin B Lack, Zhiyong Lu, Bernice Lo, Hassan Abolhassani, Ahmet Ozen, Athos Bousvaros, Scott B. Snapper, Eugene C Butcher, Juan C. Ravell, Remy Bosselut, Helen Su, Chuan Wu, Michael J. Lenardo
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An SSTR2–somatostatin chemotactic axis drives T cell progenitor homing to the intestines - Nature Immunology
Abstract Progenitors of intraepithelial T cells (IELps) migrate from the thymus to the intestines after birth where they develop into unconventional TCRγδ and TCRαβ lymphocytes in a process of extrathymic lymphopoiesis within cryptopatches. Mechanisms of IELp migration have remained unclear. Here we show that thymic IELps express the somatostatin receptor SSTR2, which contributes to their homing to the gut.
A lymphocyte chemoaffinity axis for lung, non-intestinal mucosae and CNS - Nature
Abstract Tissue-selective chemoattractants direct lymphocytes to epithelial surfaces to establish local immune environments, regulate immune responses to food antigens and commensal organisms, and protect from pathogens. Homeostatic chemoattractants for small intestines, colon, and skin are known1 2, but chemotropic mechanisms selective for respiratory tract and other non-intestinal mucosal tissues (NIMT) remain poorly understood.
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