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GABA signaling activation drives glioblastoma progression in female mice through myeloid-derived suppressor cells

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By Asmita Pathak, Palavalasa Sravya, Bruno Colon, Yadi Zhou, Brandon Leon, Jonathan Mitchell, Beatriz Mateo-Victoriano, Andrew Scott, Harrison Wong, Li Zhang, Juyeun Lee, Kristen E. Kay, Efe Karaca, Diana H. Chin, Haleh Amirian, Irem Karaman, Katelyn Sellick, Danielle Dean, Daniel Cortes, Jashodeep Datta, Scott M. Welford, Maria Franco, Kiran Kurmi, Ashish Shah, Feixiong Cheng, Justin D Lathia, Priyamvada Rai, David B. Lombard, Costas A. Lyssiotis, Dionysios C. Watson, Michele Ceccarelli, Daniel Wahl, Defne Bayik, Erika Ciervo, Oriana Y. Teran Pumar, Durga Prasad Gannamedi, Preyasha Shrestha
| Nature Verified
Abstract Sex differences in immune responses impact cancer outcomes and treatment response, including in glioblastoma (GBM). However, host factors underlying distinct immune-cancer interactions are poorly understood. Here we identify γ-aminobutyric acid (GABA) as a female-specific driver of GBM-promoting immune response.
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