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David B. Lombard on Muck Rack

David B. Lombard

As seen in: Nature, Science Magazine, Cell Press, Dialnet - Universidad de La Rioja, Diabetes Magazine, Cancer Discovery
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Articles

GABA signaling activation drives glioblastoma progression in female mice through myeloid-derived suppressor cells

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By Asmita Pathak, Palavalasa Sravya, Bruno Colon, Yadi Zhou, Brandon Leon, Jonathan Mitchell, Beatriz Mateo-Victoriano, Andrew Scott, Harrison Wong, Li Zhang, Juyeun Lee, Kristen E. Kay, Efe Karaca, Diana H. Chin, Haleh Amirian, Irem Karaman, Katelyn Sellick, Danielle Dean, Daniel Cortes, Jashodeep Datta, Scott M. Welford, Maria Franco, Kiran Kurmi, Ashish Shah, Feixiong Cheng, Justin D Lathia, Priyamvada Rai, David B. Lombard, Costas A. Lyssiotis, Dionysios C. Watson, Michele Ceccarelli, Daniel Wahl, Defne Bayik, Erika Ciervo, Oriana Y. Teran Pumar, Durga Prasad Gannamedi, Preyasha Shrestha
| Nature Verified
Abstract Sex differences in immune responses impact cancer outcomes and treatment response, including in glioblastoma (GBM). However, host factors underlying distinct immune-cancer interactions are poorly understood. Here we identify γ-aminobutyric acid (GABA) as a female-specific driver of GBM-promoting immune response.
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Anthropocene sublimes. An introduction

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By David B. Lombard, Alison Sperling, Pieter Vermeulen
| Dialnet - Universidad de La Rioja
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Open in Who Shared View Duplicates (131) Issue with article?

High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance

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By David B. Lombard, William J. Kohler, Angela H. Guo, Christi Gendron
| Science Magazine Verified
Abstract Aging is the dominant risk factor for most chronic diseases. Development of antiaging interventions offers the promise of preventing many such illnesses simultaneously. Cellular stress resistance is an evolutionarily conserved feature of longevity. Here, we identify compounds that induced resistance to the superoxide generator paraquat (PQ), the heavy metal cadmium (Cd), and the DNA alkylator methyl methanesulfonate (MMS).
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