Brian M. Meehan

Abstract Aggressive brain tumors often exhibit immunologically ‘cold’ microenvironment, where the vascular barrier impedes effective immunotherapy in poorly understood ways. Tumor vasculature also plays a pivotal role in immunoregulation and antitumor immunity. Here, we show that small GTPase Rab27 controls the vascular morphogenesis and permeability for blood content and immune effectors.

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Original Paper Yibo Xue Department of Biochemistry, McGill University, Montreal, Quebec, H3G 1Y6 Canada Goodman Cancer Research Centre, McGill University, Montreal, Quebec, H3A 1A3 Canada These authors contributed equally to this work Search for more papers by this author Xianbing Zhu Department of Biochemistry, McGill University, Montreal, Quebec, H3G 1Y6 Canada Goodman Cancer Research Centre, McGill University, Montreal, Quebec, H3A 1A3 Canada These authors contributed equally to this work...