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Articles

A suite of enhancer AAVs and transgenic mouse lines for genetic access to cortical cell types

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By Yoav Ben-Simon, Marcus J. Hooper, Sujatha Narayan, Tanya L. Daigle, Deepanjali Dwivedi, Sharon Way, Aaron Oster Verified, David Stafford, John K. Mich, Michael J. Taormina, Refugio Martinez, Jada Roth, Jason Alexander, Shona Allen, Adam Amster, Angela Ayala, Pamela Baker, Trygve E. Bakken, Jacqueline L. Bendrick, Darren Bertagnolli, Krissy Brouner, Tamara Casper, Anish B. Chakka, Rushil Chakrabarty, Rebecca Chance, Sakshi Salil Chavan, michael CLARK, Forrest Collman, Scott Daniel, Nicholas Donadio, Nadezhda Dotson, Mariano I. Gabitto, Jazmin Garcia, Jazmín Giselle Félix García, Amanda Gary, Molly J Gasperini, Jessica Gloe, Jeff Goldy, Bryan B. Gore, Lucas T. Graybuck, Françoise Haeseleer, Zeb Haradon, Samantha Hastings, Windy Ho, Dirk Hockemeyer, Cindy Huang, Avery C. Hunker, Nelson Johansen, Danielle Jones, Brian E. Kalmbach, Emily Kussick, Changkyu Lee, Angus Y. Lee, Su Li, Elizabeth Liang, Nicholas A. Lusk, Jessica Malloy, Jocelin Malone, José Melchor, Elyse L. Morin, Dakota Newman, Lydia Ng, Kiet A. Ngo, Sven Otto, Nick Pena, Trangthanh Pham, Patrick Ray, Augustin Ruiz, Raymond Sanchez, Adriana E. Sedeño-Cortés, Noah Shepard, Lyudmila Shulga, Sherif Soliman, Saroja Somasundaram, Brian Staats, Eric R. Szelenyi, Michael Tieu, Alex Tran, Miranda Walker, Yimin Wang Verified, Natalie Weed, Morgan Wirthlin, Brooke Wynalda, Zizhen Yao, Thomas Zhou, Jeanelle Ariza, Nick Dee, Melissa Reding, Kara Ronellenfitch, Shoaib Mufti, Susan M. Sunkin, Kimberly Smith, Luke Esposito, Jack Waters, Bargavi Thyagarajan, Shenqin Yao, Ed Lein, Hongkui Zeng, Boaz P. Levi, John Ngai, Jonathan T. Ting, Bosiljka Tasic, Ximena Opitz-Araya, Joel Arbuckle, Tyler Barcelli, Stuard Barta, Cameron Bielstein, Prajal Bishwakarma, Jessica Bowlus, Gabriella Boyer, Brittny Casian, Kaity Colbert, Maxwell Departee, Peter DiValentin, Tom Egdorf, Tim Fliss, Noah Greisman, Carliana Halterman, Olivia Helback, Sydney Huff, Zoe Juneau, Madhav Kannan, Shannon Khem, Rana Kutsal, Rachael Larsen, Madison Leibly, Garreck H. Lenz, Zachary Madigan, Rachel McCue, Tyler Mollenkopf, Skyler Moosman, Victoria Omstead, Alana Oyama, Christina A. Pom, Lydia Potekhina, Shea Ransford, Dean Rette, Cade Reynoldson, Christine Rimorin, Dana Rocha, Joshua P. Sevigny, Nadiya Shapovalova, Ana R. Sigler, La’Akea Siverts, Kaiya Stewart, Cameron Trader, Toren Wood
| Cell Press Verified
Keywords epigenetics transcriptomics enhancer cell type neocortex AAV transgenic recombinase mouse human Introduction To understand how the brain works, we need to establish the structure-function relationships between the units that comprise it and the outputs of its activity.1 One approach is to gain experimental access to each building block (e.g., a cell type) and manipulate it to observe effects on an animal’s physiology and behavior.2,3,4 Historically, the definition of building blocks...
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