Articles by Cathy Chen
Salvage of host-derived geranylgeraniol limits fosmidomycin efficacy in murine Plasmodium berghei malaria
Abstract Despite promising preclinical activity, fosmidomycin has shown limited clinical efficacy against malaria. It inhibits the methylerythritol 4-phosphate (MEP) pathway, which supplies precursors for farnesyl and geranylgeranyl pyrophosphate (FPP, GGPP) synthesis and protein prenylation.
Weil to wind down after 95 years
4 min read | | Credit: shutterstock/Michael Vi After retaining a Davis Polk & Wardwell team for restructuring advice earlier this week, Weil Gotshal & Manges is planning to wind down following a string of high-profile partner departures and failed merger talks. To read more Subscribe to Global Restructuring Review Register to receive our newsletter and gain limited access to subscriber content.
Cindy Wu San Francisco investor and venture community, Defrauded me of my funds and owes me more than $150,000 in misleading investments and fake consulting fees 415-678-0630 San Francisco California
I met Cindy Wu (Asian American Berkeley Graduate in Mathematics who lives in San Francisco, her LinkedIn and Socials attached below) in a conference in Europe over a year ago. Being a female and that of Chinese origin same as me, I instantly trusted her more than others in the finance community.
NMDA receptor ablation in medial prefrontal cortex disrupts value updating and reward history integration
Abstract Schizophrenia, a serious mental illness, is associated with evidence of NMDA receptor (NMDAR) dysfunction and characterized by cognitive impairments that reflect impaired value updating and feedback-driven control. However, the cellular and circuit-level mechanisms underlying these disruptions remain unclear.
Top Aluminum Windows Manufacturer: Foshan Hoview Advances Modern Building Solutions
FOSHAN, GUANGDONG, CHINA, August 12, 2026 /EINPresswire.com/ -- As demand for durable, energy-conscious, and visually appealing building components continues to grow worldwide, **Foshan Hoview Windows and Doors Co., Ltd.** is strengthening its presence in the international architectural products market.
China’s New Regulation on Outbound Investment: What Has Changed from the Existing ODI Regime?
Jianwei (Jerry) Fang, Cathy (Yian) Chen and Ke Dong of Zhong Lun Law Firm analyse China’s newly promulgated State Council Regulation on Outbound Investment.
Sex-biased computations underlying differential set shift performance in mice
Abstract Cognitive flexibility can be defined as the ability to adaptively shift between choices or strategies based on environmental feedback. Flexibility is disrupted in numerous neuropsychiatric conditions. Individual differences in the computations supporting cognitive flexibility may reveal mechanisms of neuropsychiatric risk and resilience. One critical variable well known to influence individual differences in neuropsychiatric risk is sex.
Spatio-temporal modelling of dengue counts in the Central Valley of Costa Rica
Keywords dengue case countsendemic–epidemic modelFourier seasonalityinteger-valued GARCH modelsspatio-temporal modelling Information Type Original Paper Information Epidemiology & Infection , Volume 154 , 2026 , e34 Creative Commons This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
Robust Prediction Intervals for Time Series Forecasting: A Bootstrap and Bayesian Approach
B. X., and C. W.Chen. 2026. “Robust Prediction Intervals for Time Series Forecasting: A Bootstrap and Bayesian Approach.” Journal of Forecasting1–23. Chu, https://doi.org/10.1002/for.70126. Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The datasets used in this study are publicly available from the following sources (accessed on February 4, 2025): Monthly suicide deaths in Japan (2012-2024): National Police Agency.
Spatio-temporal modelling of dengue counts in the Central Valley of Costa Rica
Introduction Dengue is an infectious disease with both endemic and epidemic characteristics, transmitted primarily by the mosquito species Aedes aegypti and Aedes albopictus. It is the most prevalent arboviral disease worldwide, imposing significant burdens in terms of morbidity and economic impact [1]. Costa Rica, a Central American country with an area of 51,179 km2 and diverse microclimates, has faced a persistent challenge from dengue in its public health system.
Bayesian Machine Learning Model Guiding Iterative, Personalized Anticoagulant Dosing Decision-Making : ENGAGE AF-TIMI 48 Trial Analysis:
ABSTRACT Anticoagulation in atrial fibrillation often relies on a fixed dose, infrequent dose adjustment and does not incorporate patient preferences for risks of stroke, bleeding, and death. We developed a Bayesian ML model (Adele) to guide individualized long-term dosing accounting for patient preferences. Adele is a Bayesian competing-risk, multistate hazard model trained on 5,380 edoxaban-treated AF patients with pharmacokinetic (PK) data from the ENGAGE AF-TIMI 48 trial.
When your love language is giving, and theirs is… expecting.
This is your sign to stop overgiving Press enter or click to view image in full size Cindy (41) and Kevin (42), a Chinese-Canadian couple, have picked up the tab for every meal out with Kevin’s sister, Vivian (39) — for years. Because that’s what older siblings do. Out of love, out of habit, out of what’s expected. Vivian’s always broke, and that’s fine. But the one time she paid for herself in a group setting with other friends? She used it as ammo.
Why your most “vulnerable” moments keep backfiring.
This is where big feelings meet bigger truths. We unpack the messy stuff — love, family, identity, faith, culture — one trigger at a time. Here to break cycles, not burn bridges. Always feel misunderstood when you open up? This might be why. Press enter or click to view image in full size Feeling everything doesn’t mean you have to say everything. Yes, you’re allowed to feel it all. But when we offload our emotions onto someone else — we’re not communicating. We’re dysregulating — out loud.
I Thought White Kids Had It Better
But here’s what I found out that later changed everything Press enter or click to view image in full size I used to envy white kids. The way their parents talked to them like actual humans. “Hey sweetie, you alright? Talk to me — what’s going on?” “Ohhh… you’ve got a boyfriend? That’s okay. What’s his name? Tell me about him.” “Just remember to be safe, okay? Use protection.” “I love you.” (like.. WHAT?
How ‘Following Your Heart’ Might Be Why You’re Still Hurting
This is your sign to stop letting every “valid” feeling run the show. Press enter or click to view image in full size Heads up: This might mess with your mindset. We’re about to unlearn some so-called “wisdom” today — so if at any point you feel low-key triggered, pause. Come back when you’re ready to rumble (with grace and curiosity). By the end of this post, you’ll know I’m on your team. And hey — maybe I’m your new fave relationship coach.
Introducing ‘Good Girl, Gone Boundaried’ - A series on culturally fluent boundary-setting.
An emotional survival guide for Asian women who want to break cycles without burning bridges. Press enter or click to view image in full size Meet Good Girl, Gone Boundaried — A series on boundary-setting that’s culturally fluent, emotionally mature, and sturdy AF — without making you (or anyone) lose face.
What if My Repair Isn’t Enough?
For all the good-inside moms who are also the scary moms — the ones who lose it and spiral after. I yelled again. At my little boy. Louder than I meant to. More than I want to. And yes — I always repair. I hold him. I say I’m sorry. But what if that’s not enough? Will he still carry this? Even with the hug. Even with the apology What if it gets stored in his body anyway — as fear? As self-doubt? As silence? What if this becomes the story he tells himself later — about love, about safety, about me?
Touchscreen Response Precision Is Sensitive to the Explore/Exploit Trade-off
Results To understand how actions in a touchscreen decision making task are influenced by internal decision making states, we took advantage of a previously collected dataset examining sex differences in explore/exploit balance in mice in a touchscreen two-arm spatial restless bandit task. Decision making data from this novel bandit task were originally shared, and modeling results are described in Chen et al. (2021b).
What was the last thing that gave you hope in your work?
The APC booth at RightsCon 2025 Taipei was alive with energy, conversations and movements. In our small corner of the venue, we did our best to draw in passersby to introduce who we are and what we do. At times, we even had a line forming. It was a curious, bustling and inviting space. Hosted in East Asia for the first time, RightsCon 2025 took place in Taipei, Taiwan from 24 to 27 February. This year, we had only one day to engage with the community at our booth.
What was the last thing that made you feel hopeful in your work?
The APC booth at RightsCon 2025 Taipei was alive with energy, conversations and movements. In our small corner of the venue, we did our best to draw in passersby to introduce who we are and what we do. At times, we even had a line forming. It was a curious, bustling and inviting space. Hosted in East Asia for the first time, RightsCon 2025 took place in Taipei, Taiwan from 24 to 27 February. This year, we had only one day to engage with the community at our booth.
Sex-biased computations underlying differential set shift performance in mice
Abstract Cognitive flexibility can be defined as the ability to adaptively shift between choices or strategies based on environmental feedback and it is disrupted in numerous neuropsychiatric conditions. Individual differences in the computations supporting cognitive flexibility are poised to reveal mechanisms of neuropsychiatric risk and resilience. One critical variable well known to influence individual differences in neuropsychiatric risk is sex.
Two‐Year Follow‐Up of Patients With Atrial Fibrillation Receiving Edoxaban in Routine Clinical Practice: Results From the Global ETNA‐AF Program
AF atrial fibrillation BMI body mass index CHA2DS2-VASc Congestive heart failure, Hypertension, Age ≥ 75 years (doubled), Diabetes mellitus, Stroke (doubled), Vascular disease, Age 65–74 years, Sex category (female) CI confidence interval CIF cumulative incidence function COPD chronic obstructive pulmonary disease CrCl creatinine clearance CrCl CG creatinine clearance Cockcroft-Gault CRNM clinically relevant nonmajor CV cardiovascular DOAC direct oral anticoagulant ETNA Edoxaban Treatment in...
Gender Lens Investing: Unlocking Opportunities for Climate and Gender Impact
Climate change is not gender neutral and our response shouldn’t be either. Women are disproportionately impacted by climate change and biodiversity risks.
Dopamine and Norepinephrine Differentially Mediate the Exploration-Exploitation Tradeoff
Dopamine and Norepinephrine Differentially Mediate the Exploration–Exploitation Tradeoff Cathy S. Chen, Dana Mueller, Evan Knep, R. Becket Ebitz, Nicola M. Grissom Journal of Neuroscience 30 October 2024, 44 (44) e1194232024; DOI: 10.1523/JNEUROSCI.1194-23.2024
Touchscreen response precision is sensitive to the explore/exploit tradeoff
Abstract The explore/exploit tradeoff is a fundamental property of choice selection during reward-guided decision making. In perceptual decision making, higher certainty decisions are more motorically precise, even when the decision does not require motor accuracy. However, while we can parametrically control uncertainty in perceptual tasks, we do not know what variables - if any - shape motor precision and reflect subjective certainty during reward-guided decision making.
Women in Radiology Education (WIRED): An actionable step towards closing the gender gap in radiology
Keywords Gender gap Radiology Women Medical school interest group Student organization Get full text access Log in, subscribe or purchase for full access. References 1. Boyle, P. More women than men are enrolled in medical school Published 2019. Updated 2. AAMC ACGME Residents and Fellows by Sex and Specialty 3. Richter, K.P. ∙ Clark, L. ∙ Wick, J.A. ... Women physicians and promotion in academic medicine N Engl J Med. Nov 26 2020; 383:2148-2157 4. Rakestraw, S.L. ∙ Chen, H. ∙ Corey, B. ...
Dopamine and Norepinephrine Differentially Mediate the Exploration-exploitation Tradeoff
Abstract Dopamine (DA) and norepinephrine (NE) have been repeatedly implicated in neuropsychiatric vulnerability, in part via their roles in mediating the decision making processes. Although two neuromodulators share a synthesis pathway and are co-activated under states of arousal, they engage in distinct circuits and modulatory roles. However, the specific role of each neuromodulator in decision making, in particular the exploration-exploitation tradeoff, remains unclear.
Interview with OCF on their 10th anniversary: “A small change, like beginning with a single patch in open source, can strengthen the entire structure" | Association for Progressive Communications
In Taiwan, the open technology culture gained momentum following the Sunflower Student Movement in 2014, which raised public awareness of democracy and introduced many to the concept of open source. According to Singing Li, CEO, and Rosa Kuo, executive secretary at Taiwan-based APC member Open Culture Foundation (OCF), communicating the benefits, values and beliefs of open technology is still a work in progress, much like Taiwan's evolving democracy.
Residents say city has lost its identity
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British citizens in Lebanon say they feel in ‘constant danger’
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World leaders scramble to contain crisis as Israel and Hezbollah edge closer to brink of war
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‘My life is in danger but I can’t see a GP due to the IT crash’
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World leaders ‘sickened’ by assassination attempt on Trump
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Who is Masoud Pezeshkian? Iran’s reformist president
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Man shot dead in Belgrade after police officer hit with crossbow outside Israeli embassy
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Households told to submit meter readings to avoid overpaying ahead of price drop
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New portrait of Charles released as Camilla praises ‘inspiring’ Armed Forces
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'Chronic' street clutter makes London 'worse place to live,' report finds
Think twice before you drop your Pret cup onto a rubbish pile on the pavement 4 hours ago As a global and capital city, London’s pavements may not be pedestrian-friendly, potentially earning it the title of a “worse place” to live, a report finds. The study, titled “Reducing Street Clutter in Central London,” evaluated Goodge Street in W1, Charing Cross Road in WC2, and Belvedere Road in SE1.
Finally, someone has created an Underground map with how stations are actually pronounced
Don’t lie – you’ve definitely dared an international student to say ‘Leicester Square’ before 7 mins ago London Underground is an iconic signature of the country with a long history. Created in 1931, the map has evolved throughout the time with new stations, new colours indicating tube lines, and expanding its system to more of London’s zones. However, non-English speakers may struggle with the station’s name, with few words and place names pronounced phonetically.
Mucus production, host-microbiome interactions, hormone sensitivity, and innate immune responses modeled in human cervix chips
Abstract Modulation of mucus production by the human endo- and ecto-cervical epithelium by steroid hormones and associated interactions with commensal microbiome play a central role in the physiology and pathophysiology of the female reproductive tract. However, most of our knowledge about these interactions is based on results from animal studies or in vitro models that fail to faithfully mimic the mucosal environment of the human cervix.
Pharmacology Research & Perspectives
ADME absorption, distribution, metabolism, and excretion AMS accelerator mass spectrometry AUC area under the curve CKD chronic kidney disease DPM disintegrations per minute DRM drug-related material EPO erythropoietin HIF hypoxia-inducible factor HPLC high-performance liquid chromatography HPLC–MSn HPLC-tandem mass spectrometry LC-MSn liquid chromatography–tandem mass spectrometry LLQ lower limit of quantification LSC liquid scintillation counting PHI prolyl hydroxylase inhibitor TP1...
El estrés fisiológico prolongado se asocia con una tasa más baja de aprendizaje exploratorio que se agrava con la depresión
El estrés es un factor de riesgo importante para la depresión y ambos están asociados con cambios importantes en los patrones de toma de decisiones. Sin embargo, décadas de investigación solo han conectado débilmente las mediciones fisiológicas del estrés con la experiencia subjetiva de la depresión.
Mucus production, host-microbiome interactions, hormone sensitivity, and innate immune responses modeled in human endo- and ecto-cervix chips
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Dopamine and norepinephrine differentially mediate the exploration-exploitation tradeoff
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Satire-in-Brief: Edition Four 2022
Yet Another Student Has Been Forced into Small Talk About How Quickly 2022 Has Flown By “Every year. Every bloody year it’s the same conversation. Yes, I can believe it’s already August. Yes, I can believe it’s the start of Semester 2. Just shut up already,” a disgruntled third year said. First year students are rumoured to still be enjoying this icebreaker, having not yet learned the conventions of university chit-chat.
Reliable Machine Learning
Book description Whether you're part of a small startup or a planet-spanning megacorp, this practical book shows data scientists, SREs, and business owners how to run ML reliably, effectively, and accountably within your organization. You'll gain insight into everything from how to do model monitoring in production to how to run a well-tuned model development team in a product organization.
Divergent Strategies for Learning in Males and Females
Highlights • Sex influences the strategies used during reinforcement learning and decision making • Female mice used a consistent strategy that permitted faster acquisition • Male mice were more likely to change their strategy in response to prior reward • Differences in strategy are an underrecognized influence on reward-guided behavior Summary A frequent assumption in value-based decision-making tasks is that agents make decisions based on the feature dimension that reward probabilities...
Solar energy is green. Solar panels are not. AI can revolutionise their design
Solar panels are manufactured at 2,000˚C, a temperature so high it requires fossil-fuel power. They are also made using rare earth elements, the supply of which has both capacity and political issues. A new and global project is using artificial intelligence (AI) to rapidly create new designs with new materials that can make their manufacture greener and cheaper. The new designs may even bring their manufacture back to your home country, says Cathy Chen of Global Shapers.
Joen Lih Machinery Co., Ltd.
Joen Lih Machinery Co., Ltd., established in Taichung, central Taiwan in 1988, is a specialized manufacturer of various surface grinders. The company provides high-precision wafer grinding machines for the high-tech industry. A diamond-outfitted grinding wheel is fitted to the floating spindle, and the machines perform vertical grinding on hard and brittle workpieces requiring the highest degree of surface accuracy and flatness.
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