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ArticleVolume 86, Issue 13p2521-2538.e10Open access Affiliations & Notes 1Department of Cancer Medicine, Monash University, Melbourne, VIC 3004, Australia 2Department of Oncology, Alfred Health, Melbourne, VIC 3004, Australia 3Monash Proteomics and Metabolomics Facility, Monash University, Clayton, VIC 3800, Australia 4Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3004, Australia 5Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash...
Keywords PRC2 H3K27me3 H3K27me3 mimicry Polycomb PALI1 JARID2 synergy allostery epigenetics facultative heterochromatin Introduction When cell-type-specific genes are repressed, they are packed into facultative heterochromatin, comprised of Polycomb domains.
Abstract DOT1L and Menin are essential cofactors for the oncogenic activity of MLL fusion proteins (MLL-FPs) in leukaemia. However, the mechanisms underpinning the therapeutic effects of their inhibitors remain unclear. Here we identify a critical role for the non-canonical Polycomb repressive complex 1.1 (PRC1.1) in mediating the cellular responses to DOT1L and Menin inhibitors.
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