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ArticleVolume 86, Issue 13p2521-2538.e10Open access Affiliations & Notes 1Department of Cancer Medicine, Monash University, Melbourne, VIC 3004, Australia 2Department of Oncology, Alfred Health, Melbourne, VIC 3004, Australia 3Monash Proteomics and Metabolomics Facility, Monash University, Clayton, VIC 3800, Australia 4Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3004, Australia 5Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash...
Highly pigmented and non/low-pigmented melanoma cells are separable by flow cytometry using combinatorial near-infrared and 488 nm light scattering. Highly pigmented melanoma cells (HPCs) are infrequent in most melanomas and display substantially decreased clonogenicity and tumorigenicity compared to more abundant non/low-pigmented melanoma cells (LPCs). LPCs display upregulated MYC-mediated signalling and HPCs display upregulated P53-mediated signalling.
Abstract A wide range of cells respond to FGF2 by proliferation via activation of the Ras/ERK pathway. In this study we explored the potential involvement of serine/threonine kinase SIK2 in this cascade within retinal Muller glia. We found that SIK2 phosphorylation status and activity is modulated in an FGF2-dependent manner, possibly via ERK.
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