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Articles by Chen Guo
Current status and capabilities of cancer prevention and treatment in county-level hospitals in Fujian Province: a baseline survey under the hierarchical medical system
Abstract This paper presents an overall estimate on the current status and capabilities of cancer prevention and treatment at selected county-level hospitals in Fujian Province (southeast China) to obtain baseline data for further development, construction, and reformation of county-level cancer prevention and treatment centers under the hierarchical medical and healthcare system.
Prepubertal NMN Administration is associated with changes in hippocampal neurogenesis-related markers and amelioration of cognitive deficits
Abstract Schizophrenia (SCZ) is a neurodevelopmental disorder in which cognitive impairment constitutes a core determinant of long-term disability, yet existing treatments offer limited benefit. The prepubertal period represents a critical window for early intervention, as metabolic and neuroplastic abnormalities are potentially reversible.
SLC35F2 in Cancer Development and Progression
Si Shen, Zhonghao Tang, Chen Guo, Sixi Li, Anjie Chen, and Chenwei Gu contributed equally to this work. Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement Data sharing not applicable to this article as no datasets were generated or analyzed during the current study. References , and . 2019. “Structural Basis for Mammalian Nucleotide Sugar Transport.” eLife 8: e45221. , , , et al. 2019.
Inhibitory effects of Cynodon dactylon from a reservoir drawdown zone on Microcystis aeruginosa and Scenedesmus quadricauda
Abstract The dominant plant Cynodon dactylon in the drawdown zone of Danjiangkou Reservoir may release allelochemicals affecting adjacent algal communities under submerged conditions, but its impact on the growth and interactions of competing algal species remains unclear.
YTHDF1 modulates CAP1-mediated actin turnover to regulate synaptic function and anxiodepressive-like behaviors
Abstract Neuroplasticity and synaptic dysfunction are central to the pathophysiology of depression, yet their underlying mechanisms remain not fully understood. Here, we identify the m6A reader protein YTHDF1 as a key regulator of depression pathogenesis. Mice with genetic deletion of Ythdf1 exhibited anterior cingulate cortex (ACC) hyperactivity, hyperalgesia, heightened social stress sensitivity, and anxiodepressive-like behaviors following acute social stress.
MRI-based lumbar cross-sectional indentation value is associated with spinopelvic sagittal balance in patients with degenerative kyphosis
Abstract Objective: To investigate whether MRI-based paraspinal muscle morphology, assessed using the lumbar cross-sectional indentation value (LCIV), is associated with spinopelvic sagittal balance in patients with degenerative kyphosis (DK).
Quercetin ameliorates iron overload-induced liver injury via NRF2/GPX4 pathway
Abstract Ferroptosis is an iron-dependent form of regulated cell death characterized by excessive lipid peroxidation and has been implicated in the pathogenesis of hepatic injury. However, whether quercetin (Que) protects against iron overload-induced liver injury and the underlying mechanisms remain unclear.
Hydrochemical Evolution of Produced Water in Coalbed Methane Wells: Implications for Multi-Seam Co-Production in the Hancheng Block, Ordos Basin
Handling Editor: Dameng Liu Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description acgs70084-sup-0001-TableS1.docx55.4 KB Supporting Table S1 Test results of produced water samples from CBM wells and surface water samples in the Hancheng block. References , and . 2016.
Association between the CCR2-V64I polymorphism and cancer susceptibility: a meta-analysis of 20 case-control studies
Abstract According to previous studies, the CCR2-V64I polymorphism has been associated with susceptibility to various cancers, yet this relationship remains controversial. To systematically evaluate this association, we conducted a meta-analysis to summarize and validate the available evidence. We comprehensively searched the PubMed, Embase, and Cochrane Library databases and ultimately included 20 case–control studies based on relevance and quality, comprising 4438 cases and 4874 controls.
TLN1 interacts with NGFR and suppresses the development of castration-resistant prostate cancer by upregulating NGFR
Abstract Background: Prostate cancer (PCa) is a common malignant tumor in males, and castration-resistant prostate cancer (CRPC) represents an advanced stage with limited treatment options and poor prognosis. Talin-1 (TLN1) is a cytoskeletal protein implicated in tumor progression, but its specific role and mechanism in CRPC remain unclear. Methods: Mass spectrometry (MS) was used to analyze serum peptides from patients with hormone-sensitive prostate cancer (HSPC) and CRPC.
Association between hemoglobin and all-cause mortality in patients with obstructive sleep apnea and hypertension: insights from an observational study
Abstract Obstructive sleep apnea (OSA) is a widespread disorder impacting more than one billion individuals globally. Hypertension, a frequent cardiovascular comorbidity associated with OSA, can exacerbate and advance the condition. Recent research has identified a synergistic effect between anemia and OSA concerning the development of hypertension.
The role of red blood cell distribution width in prognosis prediction among critically ill patients with obstructive sleep apnea: Insights from the MIMIC-IV database | Scientific Reports
Abstract Obstructive sleep apnea (OSA) is prevalent in critically ill patients and associated with increased mortality. This study aimed to investigate the association between red blood cell distribution width (RDW) at admission and one-year mortality in critically ill OSA patients. A retrospective cohort study involving 1950 critically ill patients with OSA from the MIMIC-IV (v3.1) database.
Miltirone promotes pyroptosis via increasing pyroptosis-related protein NLRP3 and AIM2 in kidney renal clear cell carcinoma
Abstract Background: Pyroptosis, a type of programmed cell death, exerts direct influence on inflammatory processes and immune response. A previous study suggests that miltirone exhibits notable anti-tumor activities and has been shown to induce tumor cell pyroptosis. Nevertheless, the therapeutic value of miltirone in kidney renal clear cell carcinoma (KIRC) remains underexplored.
Supporting pre-service teachers’ TPACK development and technology integration in collaborative lesson planning - Humanities and Social Sciences Communications
Abstract This study utilizes a mixed-methods approach to investigate the development of technological pedagogical content knowledge (TPACK) and the integration of information and communication technology (ICT) in the collaborative lesson planning (CLP) activities among a group of pre-service teachers. A survey instrument based on the TPACK framework was employed to measure their TPACK levels across the CLP procedure.
A small population of stress-responsive neurons in the hypothalamus-habenula circuit mediates development of depression-like behavior in mice
Main text (Neuron , 3924–3939.e1–e5; December 4, 2024) We, the authors, have realized that an essential acknowledgment was omitted in the original acknowledgments section.
Tropomyosin 3 Gene Fusions in Cancers: From Mechanisms to Treatments-A Comprehensive Review
1 Introduction Gene fusions constitute pivotal genomic alterations resulting from chromosomal rearrangements, which lead to the formation of hybrid genes [1]. These hybrid genes encode fusion proteins capable of disrupting normal cellular processes and contributing to oncogenesis. Of particular interest, tropomyosin 3 (TPM3) gene fusions have been identified as significant contributors to tumorigenesis.
Formation control for multiple unmanned surface vessels with prescribed performance and model uncertainty
ABSTRACT This work investigates the formation control of multiple unmanned surface vessels (USVs) in the presence of model uncertainty and input saturation, where the separation requirements must comply with the constraints of prescribed performance. First, a novel fixed-time formation error constraint method is designed. This method strictly constrains the error between the desired and actual distances between the leader and the follower USVs within a prescribed range.
Machine learning-based optimisation algorithms for sentiment analysis: an analysis of the state-of-the-art and upcoming challenges
ABSTRACT The rapid growth of Internet-based applications, exemplified by the widespread adoption of social media platforms and weblogs, has started an era where comments and evaluations of everyday activities have become pervasive. In this context, sentiment analysis uses the capabilities of natural language processing, text analysis, and computational techniques to automate the extraction and classification of emotions and sentiments expressed in textual reviews.
A BODIPY-tagged trivalent glycocluster for receptor-targeting fluorescence imaging of live cells
A BODIPY-tagged trivalent glycocluster for receptor-targeting fluorescence imaging of live cells† Multivalent glycoclusters have been extensively used as a targeting agent for drug delivery. However, tools capable of investigating their dynamic interactions with a target receptor remain elusive. Here, we synthesized fluorescently-tagged galactoclusters for the fluorescence imaging of cells that overly express the asialoglycoprotein receptor (ASGPr).
Quantitative evaluation and prediction of the relative complexity of Sangshuping coal mine tectonics in the Hancheng mining area - Scientific Reports
Abstract In this paper, the relative complexity of the tectonics in the Sangshuping coal mine was studied. On the basis of the assumption of equal blocks, using entropy function analysis and stepwise regression analysis, an empirical formula for quantitatively evaluating structural relative complexity was established from the structural characteristics in the exposed area, and then the formula was applied to the prediction of relative tectonic complexity in the unexposed area.
MultiScaleAnalyzer for Spatiotemporal Learning Data Analysis: A Case Study of Eye-Tracking and Mouse Movement
1. Introduction The rapid development of the Internet and digital technologies has significantly transformed the landscape of education, making e-learning platforms widely accessible. This accessibility has enabled the collection of vast amounts of student learning data. And, the data have gone beyond simple statistics such as login frequency, exam accuracy, and course completion rates.
Multi-instance mining with dynamic localization for weakly supervised object detection in remote-sensing images
ABSTRACT Weakly supervised remote-sensing image object detection is crucial in the interpretation of remote-sensing images. Current mainstream approaches often focus on selecting the highest-scoring instances for training the detection network or overlook the issue of feature inconsistency within object classes during model training, leading to missed instances.
High-Flying Icebreaking Bot Nails 200m Ice Removal in 5 Minutes, Wows China
新闻频道 > 国际 > 视频 2025-03-02 作者：王梓元 来源：中国青年报客户端 The ice-breaking robot🤖 accurately descends from a high altitude to carry out ice🧊 removal operation.
“Sound on Campus” Ignites Youth Talent and Cultural Pride in China's Audio Boom
“Sound on Campus” Youth Voice Festival, co-launched by China Youth Daily and Youka Interactive, merges Chinese cultural trends with voice artistry throughdubbing, recitation, and music. Targeting a 20-million talent gap in China's booming audio sector, it offers students industry exposure via top IPs likeBlack Myth: Wukong.
14-year-old boy turned traffic light into right direction
新闻频道 > 国际 > 视频 2025-02-22 作者：傅瑞 来源：中国青年报客户端 Pan Yichen, good job! A 14-year-old boy passed the intersection, finding something wrong with the traffic light. Then he turned the light into the right direction.
US-Russia Riyadh Talks: A Step Toward Thawing Relations and a Multipolar World
On Feb 18, senior US and Russian officials met in Riyadh. The next day, Waltz said the French and UK leaders would visit the US to discuss the Ukraine crisis with Trump. Zhang Hong, researcher of Institute of Russian, Eastern European and Central Asian Studies, CASS, said the talks may lead to the partial lifting of sanctions on Russia and promote a more multipolar international structure. The US State Department said both sides reached a basic consensus.
China Unveils "1+N" Policy Package to Boost Foreign Investment
China will introduce a "1+N" policy package to stabilize foreign investment, according to the Ministry of Commerce of the People's Republic of China. Foreign-funded firms contribute nearly 7% of urban jobs, one-seventh of tax revenue, and one-third of foreign trade. By the end of 2024, over 1.239 million foreign-invested enterprises had been established in China with $2.9 trillion in cumulative investment.
Hangzhou’s Unitree Robot Becomes Your Trouble-Free Shopping Assistant
新闻频道 > 国际 > 视频 2025-02-21 作者：王梓元 来源：中国青年报客户端 Sooo reliable！🤩🤩🤩The robot developed by Unitree in Hangzhou has become a trouble-free shopping minion! 🤖🤖🤖（Source:@行走的鱼🐟 douyin） #Robot #Unitree #ReliableRobot HangzhouUnitreeTechnology By Wang Ziyuan, Chen Guo (intern)/China Youth Daily 【责任编辑：叶雨婷 编辑：陈戈辉】 分享： 中国青年报丨2025-02-21 08:19:33 中国青年报丨2025-02-21 08:04:23 中国青年报丨2025-02-21 08:04:11 中国青年报丨2025-02-21 08:03:58 中国青年报丨2025-02-21 08:04:18 中国青年报丨2025-02-21 08:04:16 中国青年报丨2025-02-21 08:19:31...
Intangible Cultural Heritage Inheritor Leads Women's Group in Emei Martial Arts Parade
新闻频道 > 国际 > 视频 2025-02-21 作者：王梓元 来源：中国青年报客户端 Awesome! 😍😍😍An inheritor of the intangible cultural heritage of Emei martial arts led a women's group on a parade.
Teen Prodigy Li Xinpeng Secures Aerials Gold; China Sweeps Podium at Asian Winter Games
Chinese 19-year-old Li Xinpeng claimed gold in men's freestyle skiing aerials at the Asian Winter Games in Yabuli, Heilongjiang, scoring 123.45 points. Teammates Yang Longxiao and veteran Olympian Qi Guangpu secured silver and bronze, marking China's first podium sweep in the event. Li's triumph highlights the nation's rising dominance in winter sports.
Asian Record Breaker!
新闻频道 > 国际 > 视频 2025-02-11 作者：李媛媛 来源：中国青年报客户端 Asian Record Breaker! 🥇🥇🥇Gao Tingyu won the men's 100-meter speed skating ⛸⛸⛸title in 9.35 seconds.
A photographer caught a high-speed train flying through the snow
新闻频道 > 国际 > 视频 2025-02-11 作者：李媛媛 来源：中国青年报客户端 So stunning! A photographer caught a high-speed train🚄🚄🚄 flying through the snow❄️❄️❄️. It's just like a white Dragon🐲, stirring white fog in the heavy snow.
Youth Ignite Ice Dreams at Harbin's 9th Asian Winter Games
Harbin hosts the 9th Asian Winter Games, uniting athletes from 34 countries and regions under the theme "Shared Dreams on Ice, United Hearts in Asia." Following the Beijing Winter Olympics, this event highlights Olympic spirit, cultural exchange, and youth empowerment. With record participation, it showcases sportsmanship and the fusion of tradition and innovation in ice and snow culture.
The association between CD40 gene polymorphisms and the risk of cancer based on a meta-analysis
Abstract Background: CD40, a constituent of the tumor necrosis factor (TNF) receptor superfamily, exhibits variable expression across different cancer types. It plays a role in mediating tumor cell proliferation, apoptosis, and survival, as well as antitumor immune responses and the tumor microenvironment. Although some studies have suggested a potential association between CD40 gene polymorphisms and cancer risk, definitive conclusions remain elusive.
Measuring the quantum state of photoelectrons - Nature Photonics
Abstract A photoelectron, emitted due to the absorption of light quanta as described by the photoelectric effect, is often characterized experimentally by a classical quantity, its momentum. However, since the photoelectron is a quantum object, its rigorous characterization requires the reconstruction of the complete quantum state, the photoelectron’s density matrix.
Colorful and Beautiful: The 54th Chengdu International Panda Lantern Fair
The 54th Chengdu International Panda Lantern Fair was held at Gaoxin Jiangtan Park on Jan 26, 2025, attracting many public visitors to admire the lanterns.
A three-year-old boy wearing diapers competes in the national hip-hop championship!
新闻频道 > 国际 > 视频 2025-01-26 作者：王玉 王梓元 来源：中国青年报客户端 A three-year-old boy 👶🏻wearing diapers competes in the national hip-hop championship! How does he make it??
Efficacy of High-Definition Transcranial Alternating Current Stimulation (HD-tACS) at the M1 Hotspot Versus C3 Site in Modulating Corticospinal Tract Excitability
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Enrichment Strategies for Low‐Abundant Single Nucleotide Mutations
Over the past three decades, significant advancements have been made in mutation enrichment methods, driven by the increasing need for precise and efficient identification of rare genetic variants associated with diseases. Mutation-enrichment methods have emerged to boost sensitivity and enable easy detection of low-frequency mutations. These methods are crucial in genomics research and clinical diagnostics, allowing for the detection of low-frequency mutations within large genomic datasets.
Non-natural sialic acid derivatives with o-nitrobenzyl alcohol substituents for light-mediated protein conjugation and cell imaging
Non-natural sialic acid derivatives with o-nitrobenzyl alcohol substituents for light-mediated protein conjugation and cell imaging† We have synthesized two sialic acid derivatives substituted with an ortho-nitrobenzyl alcohol (o-NBA) group that can undergo light-mediated conjugation with primary amines at their 5- or 9-carbon position. The o-NBA derivatives were shown to react with multiple lysine residues of human serum albumin (HSA) when exposed to 365 nm light irradiation within 10 min.
A New Stochastic Petri Net Modeling Approach for the Evolution of Online Public Opinion on Emergencies: Based on Four Real-Life Cases
1. Introduction The rapid development, vitality, and resilience of the internet and social media have broken public opinion dissemination’s time and space boundaries. The network system’s highly centralized group dissemination and interactive behaviors [1] can easily trigger public opinion crises. Unforeseen events, such as natural disasters, major accidents, and social incidents, often lead to extensive online discussions, forming a unique public opinion environment.
Isoindoline-based fluorogenic probes bearing a self-immolative linker for the sensitive and selective detection of O-GlcNAcase activity
Isoindoline-based fluorogenic probes bearing a self-immolative linker for the sensitive and selective detection of O-GlcNAcase activity† O-GlcNAcase (OGA) is implicated in several important biological and disease-relevant processes. Here, we synthesized fluorogenic probes for OGA by grafting GlcNAc directly or using a self-immolative linker to the hydroxyl position of 4-hydroxylisoindoline (BHID), a typical excited-state intramolecular proton transfer (ESIPT) probe.
Research on Integration of the Sustainable Development Goals and Teaching Practices in a Future Teacher Science Education Course
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Polyvalent mpox mRNA vaccines elicit robust immune responses and confer potent protection against vaccinia virus
Highlights • Multiple MPXV antigens are expressed in one mRNA molecule by a 2A peptide • All polyvalent MPXV mRNA vaccines induce robust immune responses to EEV and IMV antigens • The tetravalent MPXV mRNA vaccines encoding MPXV A35, B6, A29, M1 provide potent protection Summary The 2022 mpox outbreak led the World Health Organization (WHO) to declare it a public health emergency of international concern (PHEIC).
Sustainability | Free Full-Text | Soil CO2 and CH4 Dynamics and Their Relationships with Soil Nutrients, Enzyme Activity, and Root Biomass during Winter Wheat Growth under Shallow Groundwater
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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