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Articles by Chen Yang
ITLN1 suppresses colorectal cancer progression by orchestrating neutrophil maturation and spatial organization
Abstract Epithelial-derived intelectin-1 (ITLN1) is frequently downregulated in colorectal cancer, but whether it actively shapes anti-tumor immunity remains unclear. We integrate multiplex immunohistochemistry, spatial analysis, single-cell transcriptomics, chromatin-accessibility profiling, and perturbation models to define how ITLN1 regulates neutrophil maturation and spatial anti-tumor immunity.
Quality, source transparency, information reliability, and domain coverage of short video-based information on feeding guidance for people with dysphagia: a cross-sectional study on 4 major Chinese social media platforms
Abstract Background: Standardized feeding guidance is valuable for people with dysphagia, helping prevent aspiration, improve nutritional status, and enhance quality of life. In recent years, short-video platforms have become a key avenue for the public to access health information, providing people with dysphagia with a convenient channel to learn about feeding management.
Epicardial adipose tissue in obesity-related heart failure with preserved ejection fraction and atrial fibrillation: mechanisms, imaging, and therapeutic modulation
Abstract Obesity-related heart failure with preserved ejection fraction (HFpEF) and atrial fibrillation (AF) often coexist, but the contribution of epicardial adipose tissue (EAT) to their overlap remains uncertain. EAT is anatomically contiguous with the myocardium and can undergo inflammatory, profibrotic and metabolic remodeling in obesity.
PGG Enhances Olaparib Efficacy via cGAS-STING Signaling and Sensitizes Triple-Negative Breast Cancer to PD- L1 Blockade
Abstract Triple–negative breast cancer (TNBC) is a highly aggressive malignancy and options for targeted therapy are limited. Although PARP inhibitors (PARPi) like olaparib (Ola) leverage synthetic lethality, their clinical utility is severely impeded by drug resistance and low frequency of BRCA mutations.
METTL16 supports arginine biosynthesis and suppresses IL-1β production to attenuate allergic asthma
Abstract Allergic asthma is a common disease. We aimed to investigate the role of METTL16, an N6-methyladenosine (m6A) writer, in allergic asthma and epithelial homeostasis. Here we show that pulmonary METTL16 expression was decreased in patients with allergic asthma and in a murine model of allergic asthma, particularly in airway epithelial cells.
Seven Months, $78 Million: George Procopiou Reaps Windfall on Hengli-Built VLCC
A near-new VLCC delivered by Hengli Heavy Industries reportedly changes hands for $200 million, giving Dynacom a nominal sale-and-purchase gain of around $78 million as two benchmark VLCC routes breach $1 million per day in theoretical TCE earnings. By Chen Yang, Xinde Marine News Greek shipping magnate George Procopiou has pulled off another remarkable asset play.
Associations between DigComp 2.2-based digital competence and multidimensional health literacy among older adult learners in Shanghai Universities of the Third Age: a cross-sectional study
Abstract Background: Digital competence may influence older adults' engagement with health information in increasingly digitalized societies. However, evidence on the association between DigComp 2.2-based digital competence and multidimensional health literacy remains limited. This study examined digital competence levels and its associations with health literacy domains among older adult learners in Shanghai Universities of the Third Age.
World’s Largest Product Tanker Operator Posts $278 Million Quarterly Profit
By Chen Yang, Xinde Marine News Hafnia, widely regarded as the world’s largest product tanker operator, has reported a sharp increase in earnings, delivering its strongest quarterly performance since the third quarter of 2022. The company recorded a net profit of $277.8 million in the second quarter of 2026, nearly 3.7 times the $75.3 million earned in the corresponding period last year.
Radiographic evidence of thymic involution in hepatocellular carcinoma: a propensity score-matched study in viral cirrhosis
Abstract Purpose: Adult thymic involution has been implicated in impaired antitumor immunity, but whether hepatocellular carcinoma (HCC) is associated with structural thymic involution in humans remains unclear. This study evaluated parameters of thymic CT imaging in compensated liver viral cirrhotic patients with or without concomitant HCC.
Umbrella-type stretchable electrode arrays for long-term neural recording
Abstract Flexible implantable neural electrodes have been studied extensively due to their chronic single-unit recording capability over weeks or months. However, high-density stable recording of the same neuronal ensembles over years-long periods remains challenging. Here we address this challenge by developing umbrella-type stretchable electrode arrays, which are anchored to surrounding brain tissue, forming a seamless neuroelectronic interface.
1D NLSE cavity-loop modeling of the output spectrum of a 100 MHz Kerr-lens mode-locked Ti:sapphire laser
We report a six-mirror X-fold Kerr-lens mode-locked (KLM) titanium:sapphire (Ti:sapphire) femtosecond laser operating at a repetition rate of approximately 100 MHz. By varying the long-to-short arm-length ratio, the dominant output spectral peak of the laser is tuned across approximately 723–783 nm.
Perioperative immunochemotherapy for resectable gastric or gastroesophageal junction cancer: a meta-analysis of efficacy and safety from randomized trials
Abstract Background: The efficacy and safety of perioperative immune checkpoint inhibitors (ICIs) combined with chemotherapy for resectable gastric/gastroesophageal junction (GEJ) cancer remain to be definitively established. This meta-analysis aimed to synthesize the latest evidence from randomized controlled trials (RCTs) on this emerging therapeutic strategy.
From Local Clusters to Global Production: The Role of Producer Services Agglomeration in China's GVC Position
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement Data available on request from the authors. References , and . 1992. “A Model of Growth Through Creative Destruction.” Econometrica 60, no. 2: 323–351. , and . 2009. The Economics of Growth. MIT Press. , , , , and . 2021. “The Nature of Innovation in Global Value Chains.” Journal of World Business 56, no. 4: 101221. , and . 2009. Mostly Harmless Econometrics: An Empiricist's Companion. Princeton University Press.
Orbital asymmetry degree: a potential 99m Tc-DTPA SPECT/CT imaging marker for diplopia in thyroid-associated ophthalmopathy
Abstract Background: Diplopia is a common and clinically important manifestation of thyroid-associated ophthalmopathy (TAO), often related to asymmetric orbital involvement. This study investigated the association between orbital asymmetry degree (OAD), a novel quantitative imaging index derived from 99mTc-DTPA SPECT/CT, and diplopia in patients with TAO. Methods: A1:1 matched case–control study was conducted, including 22 matched pairs of patients with TAO with or without diplopia.
Salience network hub dysfunction is associated with cognitive impairment in self-limited epilepsy with centrotemporal spikes: An OPM-MEG study
Children with SeLECTS showed lower planning, attention, successive processing, and full-scale CAS scores. OPM-MEG revealed reduced theta-, alpha-, and beta-band connectivity, most prominently in the beta band. Reduced beta-band salience network centrality was associated with poorer cognition and may be a MEG marker. 1 INTRODUCTION SeLECTS is the most common idiopathic focal epilepsy in childhood.
Evo-Bench: Can Language Models Improve Agent Harness?
Published on Aug 10 · Submitted by Huang Lisheng on Aug 11 · RUC-AIBOX Abstract Large Language Models (LLMs) have driven rapid progress in autonomous agents, yet standard evaluations remain confined to static task solving. An emerging frontier is harness evolution---the agent's capacity to autonomously optimize its own operating harness.
Development of an early auxiliary diagnostic model for disseminated tuberculosis in HIV-negative tuberculosis patients
Abstract Background: Disseminated tuberculosis (DI-TB) can induce multiple organ dysfunction syndrome and carries a high mortality rate. This study aimed to establish an early-warning diagnostic model to facilitate the identification of DI-TB high-risk patients and improve clinical prognosis. Methods: We retrospectively enrolled 1,122 HIV-negative hospitalized patients with disseminated tuberculosis (DI-TB) or pulmonary tuberculosis (PTB) admitted to Nanjing Second Hospital.
A Novel Uncertainty-Integrated Design of Force Reconstruction and Control for Compliant Space Docking
Data Availability Statement The authors have nothing to report. References 1, , , and , “Improved Sliding Mode Tracking Control for Spacecraft Electromagnetic Separation Supporting On-Orbit Assembly,” Advances in Space Research 73, no. 9 (2024): 4711–4720, https://doi.org/10.1016/j.asr.2024.01.034. 2, , , , and , “Design and Analysis of a Large Tolerance Docking Mechanism,” Acta Astronautica 221 (2024): 121–141, https://doi.org/10.1016/j.actaastro.2024.05.014.
OmniVAE: An Audio-Video VAE with Cross-Modal Alignment for Joint Generation
Models citing this paper 0 No model linking this paper Cite arxiv.org/abs/2607.23855 in a model README.md to link it from this page. Datasets citing this paper 0 No dataset linking this paper Cite arxiv.org/abs/2607.23855 in a dataset README.md to link it from this page. No Space linking this paper Cite arxiv.org/abs/2607.23855 in a Space README.md to link it from this page.
Traditional Chinese medicine product heads to US as dietary supplement
by CHEN Yang After an overseas dealmaking boom among China's innovative drug makers, the country's traditional medicine sector is now getting in on the act. TCMG, a US-based company that helps commercialize traditional Chinese medicines, and Chinese drug maker Mengyang Pharmaceutical announced on July 21 that they had completed a cross-border licensing deal, Jiemian News has learned. Under the agreement, TCMG will receive exclusive rights to market Shengbai Oral Liquid in the US for 20 years.
Dual-channel graph neural network for dental 3D point cloud model segmentation
Abstract By using 3D teeth segmentation via Intraoral scan, digitized dentistry becomes possible and easy. 3D instance segmentation is complex due to the complicated architecture of intraoral scan teeth, lack of boundary between adjacent teeth, and point cloud data noise. Primary methods cannot simultaneously obtain local and global connection data to the dental arches in areas with overlapping archform and crowded arch dimensions, resulting in the errors that are found there.
Ultrafast reconfigurable topological-modulators-based photonic processing accelerator
Abstract The rise of artificial intelligence has triggered exponential growth in data volume, demanding rapid and efficient processing. High-speed, energy-efficient, and parallel-scalable computing hardware is thus increasingly critical. We demonstrate a wafer-scale non-volatile photonic computing chip using topological modulators.
Computer Science > Software Engineering
Automated unit test generation has recently benefited from advances in large language models (LLMs), yet our industrial deployments reveal a persistent gap between promising research results and practical usability. In real-world projects with complex frameworks and cross-file dependencies, LLM-generated tests frequently fail to compile, require costly manual repair, or provide unstable coverage improvements.
Docosahexaenoic acid attenuates cisplatin nephrotoxicity by restoring mitophagy
Abstract Cisplatin exhibits potent antitumor efficacy but also causes dose-dependent nephrotoxicity mediated through apoptosis of renal tubular epithelial cells, which limits its clinical application. Cisplatin induces significant mitophagy in these cells; however, the mechanisms underlying its effects on apoptotic processes remain incompletely elucidated.
Unlocking the capacity of Mn-based Prussian blue cathodes in capacitive deionization
Abstract Manganese (Mn)-based Prussian blue analogs (PBAs) typically exhibit suboptimal electrochemical performance due to their inherent Jahn-Teller effect distortion and low electrical conductivity. Here, a potassium substitution and high entropy strategy is proposed to synergistically construct K2(FeMnCoNiCu)[Fe(CN)6] (K-HEHCF) cathode to address the aforementioned issues.
Asiatic acid remodels the gastric precancerous immune microenvironment by targeting STING
Abstract Introduction: Chronic inflammation-driven gastric precancerous lesions (GPL) are characterized by progressive immune remodeling toward an immunosuppressive state, yet effective chemopreventive agents targeting this process remain scarce. Here, we identify asiatic acid (AA), a natural pentacyclic triterpenoid, as a STING‑binding compound that contributes to reshaping the gastric immune microenvironment and interfering with the Correa cascade.
Quantization of geometric-like coupling in gravitational field based on characterization and transformation
Abstract Connections between the formulations of physics and geometry have been evident throughout history, from classical mechanics to general relativity. Independently, quantum mechanics has been established in flat space. In this study, we investigate the geometric-like coupling of a test particle and its quantized form in a gravitational field. The main text consists of three parts: the characterization of the particle and its operator form is pointwise established.
Breaking the O 2 Activation Bottleneck via Synergistic Electronic Polarization at Adjacent Co–Mn Sites in N-Doped Carbon
Longjie Yu and Bo Liu have equal credit among all the authors. , , , et al. “Breaking the O2 Activation Bottleneck via Synergistic Electronic Polarization at Adjacent Co–Mn Sites in N-Doped Carbon.” Chemistry – A European Journal (2026): e71334. https://doi.org/10.1002/chem.71334 Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request.
Periodic sampled-data adaptive controller for hyperbolic PDE–ODEs cascade systems
, , , and , Periodic sampled-data adaptive controller for hyperbolic PDE–ODEs cascade systems, Asian J. Control. (2026), 1–10. https://doi.org/10.1002/asjc.70181 1 INTRODUCTION In recent decades, with the widespread use of digital platforms, sampled-data control has become very popular [3, 5, 24]. Regarding the stability and control design of ordinary differential equations (ODEs) systems with sampled data, a lot of results have been obtained (see, e.g., [9, 11, 19]).
Enantioselective construction of polychiral helical compounds via dynamic kinetic resolution
Abstract Chiral helicenes and their derivatives are valuable across diverse research fields, yet the development of helical chirality has lagged far behind that of point and axial chirality. The synthesis of polychiral or heteroatom-containing helical systems remains especially challenging because of limited starting materials and difficulties in stereochemical control.
Risk factors for malnutrition and its impact on prognosis in patients with severe pneumonia
Abstract Background: Malnutrition is common in acute and critical illness, but its clinical correlates and prognostic relevance in severe pneumonia remain incompletely characterized. This study investigated factors associated with malnutrition at admission and its association with short-term outcomes in patients with severe pneumonia. Methods: In this retrospective cohort study, adults with severe pneumonia treated between January 2021 and December 2024 were consecutively included.
Large language model consensus substantially improves the cell type annotation accuracy for scRNA-seq data
Abstract The rapid expansion of single-cell RNA sequencing (scRNA-seq) has made accurate cell type annotation a critical bottleneck for biological discovery. Existing computational methods are often limited by reference data dependency, while emerging single Large Language Model (LLM) approaches are susceptible to model-specific biases and provide insufficient uncertainty quantification.
NeoVolta: From Dilution Pain To Commercial Inflection
Jun 05, 2026, 4:56 PM ET, , Summary NeoVolta (NEOV) is positioned to benefit from the OBBBA, leveraging FEOC-compliant domestic manufacturing to capture market share as ITC rules shift in 2026. NEOV's strategic partnership with Infinite Grid Capital secures a $200M LOI for 1.1GWh BESS projects, targeting utility and AI data center markets. Production at NEOV's Georgia facility is set to begin in Q3 2026, supported by recent $47M capital raises and a strong project pipeline.
A wearable paper-based SGR/MCC microneedle array sensor for continuous glucose monitoring
Abstract Continuous glucose monitoring (CGM) is a promising approach for managing blood glucose levels in individuals with diabetes. However, the emerging microneedle (MN) technologies for colorimetric or electrochemical detection of glucose in sampled dermal interstitial fluid (ISF) remain far from practical CGM due to many concerns.
IS110 transposon utilizes two mechanistically distinct RNA-guided transposition pathways
Keywords IS110 bRNA transposition excision rejoining target donor copy-out replicative Get full text access Log in, subscribe or purchase for full access. References 1. Siguier, P. ∙ Gourbeyre, E. ∙ Varani, A. ... Everyman's Guide to Bacterial Insertion Sequences Microbiol. Spectr. 2015; 3 MDNA3-0030-2014 2. Fedoroff, N.V. Transposable elements, epigenetics, and genome evolution Science. 2012; 338:758-767 3. Knott, G.J. ∙ Doudna, J.A. CRISPR-Cas guides the future of genetic engineering Science.
Targeting tumor-intrinsic STK40 induces immune vulnerability and drives T cell reinvigoration
Keywords hepatocellular carcinoma CRISPR screening STK40 anti-tumor immunity immunotherapy Get full text access Log in, subscribe or purchase for full access. References 1. Llovet, J.M. ∙ Castet, F. ∙ Heikenwalder, M. ... Immunotherapies for hepatocellular carcinoma Nat. Rev. Clin. Oncol. 2022; 19:151-172 2. Sangro, B. ∙ Sarobe, P. ∙ Hervás-Stubbs, S. ... Advances in immunotherapy for hepatocellular carcinoma Nat. Rev. Gastroenterol. Hepatol. 2021; 18:525-543 3. Wang, Z. ∙ Wang, Y. ∙ Gao, P. ...
Human milk phospholipids across lactation stages and their associations with infant neurodevelopment: a prospective cohort study in China
Abstract Introduction: Early-life nutrition is a key determinant of infant neurodevelopment. Phospholipids (PLs) in human milk contribute to neuronal membrane structure and signaling, yet population-based evidence linking milk PLs to early neurodevelopment remains limited. This study aimed to examine dynamic changes in breast milk PLs across lactation and their associations with infant neurodevelopment at 6 months.
Sa1724 REVEALING THE BRAIN EFFECTS OF ELECTROACUPUNCTURE IN FD RATS WITH IMMUNOFLUORESCENCE AND VIRAL TRACING
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252 DIGITAL MONITORING CAN HELP ACHIEVE DISEASE CONTROL AND TREAT TO TARGET GOALS IN INFLAMMATORY BOWEL DISEASE CENTERS: RESULTS FROM ALL4IBD PROSPECTIVE MULTI-SITE PRAGMATIC TRIAL
Also available on ScienceDirect
Sa1711 ELECTROACUPUNCTURE FOR FUNCTIONAL DYSPEPSIA: A 2×2 FACTORIAL RANDOMIZED CONTROLLED TRIAL
Also available on ScienceDirect
Chinese drugmakers need systematic global capabilities
2026-04-30 23:15:02 来源: 界面新闻 by CHEN Yang Shanghai should encourage innovative drug companies to develop systematic global capabilities, said Wang Yan, board secretary of Shanghai Henlius Biotech, at the "Shanghai 2035: Answers for the Future" biopharma roundtable. Founded in Zhangjiang in 2010, Shanghai Henlius Biotech has grown into a biopharmaceutical company with more than 4,000 employees.
Predictive value of peripheral blood eosinophil levels and dynamics for efficacy and safety of immune checkpoint inhibitors in non-small cell lung cancer: a real-world study
Abstract Heterogeneous benefits from immunotherapy in advanced driver gene–negative non-small cell lung cancer (NSCLC) underscore the need for biomarkers predicting efficacy and immune-related adverse event (irAE) risk. Eosinophils, routinely measured in peripheral blood and involved in antitumor immunity, may serve as practical biomarkers for predicting the efficacy and safety of immune checkpoint inhibitors (ICIs).
Data analysis of residents aged 40–59 in colorectal cancer screening in Pudong New Area, Shanghai, 2013–2023
Abstract To analyse the colorectal cancer (CRC) screening results for residents aged 40–59 years in Shanghai’s Pudong New Area from 2013 to 2023; evaluate the initial screening outcomes, colonoscopy compliance, and the detection rates of intestinal lesions; and provide evidence to support the optimization of local CRC screening programs. This study included residents aged 40–59 years who participated in the CRC screening program in Pudong New Area from 2013 to 2023.
Duality Biotherapeutics eyes STAR IPO after $6bn in overseas ADC deals
by CHEN Yang Despite securing more than $6 billion in overseas licensing deals, Duality Biotherapeutics is pursuing a STAR Market IPO to fund late-stage trials and commercialization. The China-based ADC developer said on April 13 that its board had approved plans to list on Shanghai's STAR Market. The plan requires shareholder approval on April 29 and regulatory clearance. Duality Biotherapeutics plans to raise up to 6.75 billion yuan (about $988 million).
Miniaturized optically generated Bessel beam ultrasound for volumetric transcranial brain stimulation
Abstract Noninvasive stimulation of small, variably shaped brain subregions is crucial for advancing our understanding of brain functions. Current ultrasound neuromodulation faces two major trade-offs when targeting brain subregions: miniaturization versus volumetric control and spatial resolution versus transcranial capability. Here, we present an optically generated Bessel beam ultrasound (OBUS) device designed to overcome these limitations.
Case Report: Debridement with vacuum sealing drainage for conservative management of post-cranioplasty surgical site infection
Abstract Post-cranioplasty infection represents a challenging complication in neurosurgical practice. Conventional therapeutic strategies typically necessitate implant removal or decompressive craniectomy, often resulting in secondary trauma and increased healthcare burden. We report a 55-year-old male patient who underwent decompressive craniectomy following traumatic brain injury and subsequently received cranioplasty with polyetheretherketone (PEEK) material.
Synergistic acousto-optical profiling of morphodynamic features for smart detection of acute lymphoblastic leukemia
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Keywords acoustic-optical biosensing label-free detection point-of-care testing acoustic streaming optical Fourier analysis acute lymphoblastic leukemia ALL Introduction Acute lymphoblastic leukemia (ALL) is a life-threatening hematologic malignancy with high mortality, and its 5-year survival rate typically remains below 20%–30%.1,2,3,4 Early screening for ALL, particularly the identification of malignant lymphoblasts, plays a pivotal role in clinical decision-making from initial diagnosis...
By Yifan Wang Verified, Shukun Zhao, Xiaoqi Gao, Yantong Liu, Chen Yang, Tao Jiang, Yihan Ma, Keyu Chen, Hongqiang Jiang, Fuling Zhou, Yi Yang, Xiaotong Si, Shanpeng Dong
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Cell Reports Physical Science
Verified
Disrupted Modular Integration of the Reward System Is Associated With Social Deficits in Autism Spectrum Disorder
1 Introduction Impaired social functioning is a core feature of autism spectrum disorder (ASD) (Pelphrey et al. 2011). Atypical social behaviors in ASD, such as lack of social–emotional reciprocity, reduced social motivation, impaired facial expression and gaze processing, difficulties in action imitation and understanding, and deficits in inferring others' intentions, feelings, and perspectives (Hobson and Meyer 2005; Hyman et al.
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