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Chia-Ho Lin on Muck Rack

Chia-Ho Lin

As seen in: MDPI, BioRxiv, Cell Stem Cell, Cell Press, Genome Research, Genes and Development Journal
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Articles

The Rbfox1/LASR complex controls alternative pre-mRNA splicing by recognition of multipart RNA regulatory modules

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By Parham Peyda, Chia-Ho Lin, Kelechi Onwuzurike, Douglas Black
| Genes and Development Journal
1,2,4,5 1Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California 90095, USA; 2Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, California 90095, USA; 3Medical Scientist Training Program, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA; 4Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles,...
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Cancer-associated SF3B1 mutation K700E causes widespread changes in U2/branchpoint recognition without altering splicing.

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By Andrey Damianov, Chia-Ho Lin, Jian Zhang, James L. Manley
| BioRxiv
Abstract Myelodysplastic syndromes and other cancers are often associated with mutations in the U2 snRNP protein SF3B1. Common SF3B1 mutations, including K700E, disrupt SF3B1 interaction with the protein SUGP1 and induce aberrant activation of cryptic 3 ′ splice sites (ss), presumably resulting from aberrant U2/branch site (BS) recognition by the mutant spliceosome.
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The Rbfox1/LASR complex controls alternative pre-mRNA splicing by recognition of multi-part RNA regulatory modules

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By Parham Peyda, Chia-Ho Lin, Douglas L. Black, Kelechi Onwuzurike
| BioRxiv
Abstract The Rbfox proteins regulate alternative pre-mRNA splicing by binding to the RNA element GCAUG. In the nucleus, most of Rbfox is bound to LASR, a complex of RNA-binding proteins that recognize additional RNA motifs. However, it remains unclear how the different subunits of the Rbfox/LASR complex act together to bind RNA and regulate splicing. We used a nuclease-protection assay to map the transcriptome-wide footprints of Rbfox1/LASR on nascent cellular RNA.
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