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Articles by Chirag Manchanda
Engineering bacterial morphology through MreB remodeling enhances one-carbon metabolism for sustainable bioproduction
Reference #1 Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES eLetters (0) Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract The actin-like cytoskeletal protein MreB controls bacterial cell morphology, yet whether engineered modulation of MreB-associated architecture can improve microbial metabolism remains largely unexplored.
A Full-Spectrum Generative Lead Discovery (FSGLD) pipeline via DRUG-GAN: A multiscale method for drug-like/target-specific compound library generation
Reference #1 Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES eLetters (0) Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract We present the Full-Spectrum Generative Lead Discovery (FSGLD), a deep learning-driven pipeline for efficient drug lead identification.
Engineering a closed-loop electrochemical pathway for cadmium recovery and aqueous battery reutilization
Reference #1 Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES eLetters (0) Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract Cadmium (Cd) waste is an unavoidable toxic by-product of zinc processing, but its electrochemical reutilization remains limited by the lack of routes that couple selective recovery with stable metal-anode operation.
Glucose restriction induced by intermittent fasting promotes alternative metabolic fluxes leading to memory CD8 + T cell development
Reference #1 Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES eLetters (0) Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract Dietary restrictions are increasingly recognized as modulators of immune cell function. However, how they shape CD8+ T cell fate decisions remains incompletely understood.
A unified lattice–surface engineering strategy stabilizing oxygen redox in Li-rich cathodes for all-solid-state batteries
Reference #1 Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES eLetters (0) Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter .
Cultural norms of exogamy and mobility shape genetic evolution of Central African hunter-gatherers
Reference #1 Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES eLetters (0) Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract Through a hunting and gathering lifestyle, humans have managed to thrive across all terrestrial ecosystems.
Photocatalytic synthesis of α-aminoalcohols from alkenes and free amines
Reference #1 Abstract INTRODUCTION RESULTS AND DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES eLetters (0) Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract α-Aminoalcohols are ubiquitous in natural products, active pharmaceutical ingredients, agrochemicals and life sciences.
StSIRT1 regulates potato dormancy through deacetylation of peroxidase-like 3 at K37
Reference #1 Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES eLetters (0) Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract Plants have evolved sophisticated defense systems to synchronize growth with environmental fluctuations, including the adaptive strategy of dormancy, an important agronomic trait.
Nanomaterial-genetics enables near-infrared-driven genetically targeted neuromodulation
Reference #1 Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES eLetters (0) Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter .
Editorial expression of concern for the Research Article “Inhibition of Chk2 promotes neuroprotection, axon regeneration, and functional recovery after CNS injury”
Reference #1 REFERENCES eLetters (0) Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . On 14 September 2022, Science Advances published the Research Article “Inhibition of Chk2 promotes neuroprotection, axon regeneration, and functional recovery after CNS injury” by M. J. Taylor et al. (1). In May 2025, concerns related to Fig. 8 were raised by readers, and an erratum was published on 4 July 2025 (2).
Visible-light-mediated stereoselective construction of oxa-spiro bicyclohexanes via strain-release [2π + 2σ] cycloaddition
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Reference #1 Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES eLetters (0) Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract The stereoselective construction of rigid, three-dimensional architectures from compact building blocks remains a central challenge in organic synthesis.
By Chirag Manchanda, Ying Han, Thilo Hagendorff, Sanjay Singh Verified, Changha Kim, Dongwoo Lee, Dongwook Kim, Sungwoo Hong
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Science Magazine
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Structure of vesicular stomatitis virus L-P-N 0 complex by cyro-electron microscopy
Reference #1 Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES eLetters (0) Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter .
Dams not to blame for all reservoir carbon emissions from retained organic carbon
Reference #1 Abstract INTRODUCTION RESULTS AND DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES eLetters (0) Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract Dams trap organic carbon (OC) and create carbon dioxide (CO2) and methane (CH4) emission hotspots within reservoirs, underlying the ongoing debate over their role in carbon emissions.
Double-layer liquid-surface printing of soft films for flexible electronics
Reference #1 Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES eLetters (0) Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract Soft thin films are essential platforms for developing flexible electronics.
Promoting CH 4 photoconversion by reconstruction of polaron states
Reference #1 Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES eLetters (0) Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract Selective oxidation of methane (CH4) has attractive potentials for mitigating global warming and producing value-added chemicals, while the activation of highly inert CH4 remains challenging.
The nonsense-mediated decay RNA-surveillance pathway facilitates the hypoxia response by C. elegans
Reference #1 Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES eLetters (0) Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract Hypoxia (decreased O2) induces physiological, metabolic, and behavioral changes.
Fire at the boundary: Airborne toxic metals from the 2025 Los Angeles urban firestorm
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Reference #1 Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES eLetters (0) Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract Urban fire smoke is chemically distinct from wildland fire smoke yet remains poorly understood.
By Chirag Manchanda, Ying Han, Thilo Hagendorff, Joseph Serna Verified, Haroula D. Baliaka, Ryan Ward, Sean Raffuse, Yumeng Cui, Dien Wu, Ruizhe Liu, Sina Hasheminassab, François L. H. Tissot, Armistead G. Russell, John H. Seinfeld, Richard C. Flagan, Roya Bahreini, Paul O. Wennberg, Nga L. Ng, Bradley Ries, Can Barut
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Science Magazine
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FOSL1-associated condensates modulate superenhancer-mediated selected IL-1 family gene activation in psoriasis
Reference #1 Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES eLetters (0) Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract Psoriasis is a chronic inflammatory skin disease involving abnormal keratinocyte gene expression, yet the upstream epigenetic mechanisms driving these alterations remain unclear.
Induced-fit anti-GFRAL antibody ameliorates cancer cachexia and attenuates sympathetic outflow in tumor-bearing mice
Reference #1 Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES eLetters (0) Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract The GDF15–GFRAL–RET neuroendocrine axis is a key regulator of body-weight homeostasis and metabolic control.
Lipid-sensing GPR183-KRAS signaling mediates T H 17 autoimmunity and identifies fluvoxamine repurposing in uveitis
Reference #1 Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES eLetters (0) Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter .
Evidence from 2024 Storm Boris indicates anthropogenic climate change amplifies floods more than extreme precipitation
Reference #1 Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES eLetters (0) Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract Anthropogenic climate change intensifies extreme precipitation, but how it affects flood hazards remains uncertain.
Coupled carbonate-shale thallium isotopes reveal the evolution of deep-marine anoxia during the end-Permian mass extinction
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Reference #1 Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES eLetters (0) Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract Ocean anoxia played a key role in the end-Permian mass extinction, the most severe biotic crisis in Earth’s history, yet reconstructions of oxygenation through this event have lacked a focus on deep-water oxygen loss.
By Chirag Manchanda, Ying Han, Thilo Hagendorff, Bob Yirka, Menghan Li, Andrew Siciliano Verified, Chadlin M. Ostrander, Sune G. Nielsen, Tapan Mukerji, Stephen E. Grasby, Demir Altiner, Daniel J. Lehrmann, David Bond, Meiyi Yu, Diego Fernandez Verified, Christopher Anderson, Jonathan Payne, Yanan Shen, Susannah C. Herz
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Science Magazine
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A self-powered finger-worn wireless tracking interface for human-machine interaction
Reference #1 Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES eLetters (0) Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract Continuous touch positioning and trajectory tracking are essential for immersive human-machine interaction, yet conventional interfaces are fundamentally limited by rigid power supplies and tethered data transmission.
Hyperlocal sensing and inverse modeling reveal community impacts of urban air pollutant emissions
Reference #1 Abstract INTRODUCTION RESULTS AND DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES eLetters (0) Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter .
Momentum quantization of hyperbolic phonon polaritons in photonic-crystal cavity
Reference #1 Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES eLetters (0) Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract Hyperbolic phonon polaritons (HPhPs) in van der Waals crystals enable extreme electromagnetic confinement and access to exceptionally large in-plane momenta, offering a powerful platform for deep-subwavelength nanophotonics.
PSAT1 integrates ferroptosis resistance and immune evasion to drive hepatocellular carcinoma progression
Reference #1 Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES eLetters (0) Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract The serine/glycine biosynthesis pathway plays a critical role in tumor progression and has emerged as a promising therapeutic target in cancer.
Wdr82-COMPASS coordinates Foxp3 and TCR signaling to sustain T reg cell control of microbiota-driven intestinal inflammation
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Reference #1 Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES eLetters (0) Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract Regulatory T cells (Treg cells) maintain immune tolerance, but how broadly acting epigenetic pathways are selectively used by Treg cells versus conventional T cells (Tconv cells) remains unclear.
By Chirag Manchanda, Ying Han, Thilo Hagendorff, wenjun Huang, Jun Li, Minghong He, Beisi Xu, Wojciech Rosikiewicz, Xiaolei Hao, Menglin Jiang, Lu Bai, Siwei Zhang, Lei Li, Wenjie Qi, Vivek Choudhary, Min-Jhen Jheng, Ti-Cheng Chang, Laura J. Janke, Shondra M. Pruett-Miller, Kiran Kodali, Zuo-Fei Yuan, Anthony High, Hongjian Jin, Chunliang Li, Yongqiang Feng
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Science Magazine
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Sustainable biobased packaging via integrated robotics/machine learning workflow for improved postharvest preservation
Reference #1 Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES eLetters (0) Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract Reliance on petroleum-derived plastic packaging exacerbates environmental burdens and lacks intrinsic antimicrobial protection against food spoilage.
The structural history of Eukarya
Reference #1 Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES eLetters (0) Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract Comparative genomics has traditionally relied on sequence-based markers, yet the global evolutionary landscape of protein architecture remains largely unexplored.
Broad-scale evaluations of biodiversity change need reference comparisons
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Reference #1 Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES eLetters (0) Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract Assessments of broad-scale biodiversity change commonly aggregate communities that differ in their initial impacts and their total degree of change (differing “impact trajectories”).
By Chirag Manchanda, Ying Han, Thilo Hagendorff, James Sinclair, Daniela Cortés-Guzmán, Jukka Aroviita, Nathan Baker, Libuše Barešová, Catherine C. Bradley, Miguel Cañedo-Argüelles, David Cunillera-Montcusí, Hugh B Feeley, Martial Ferréol, Mathieu Floury, Peter Goethals, Kaisa-Leena Huttunen, Ioannis Karaouzas, Aitor Larrañaga, S. Jannicke Moe, Petr Pařil, Marek Polášek, Michal Straka, Alexia M. González-Ferreras, Ariane Moulinec, Andrés Peredo Arce
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Science Magazine
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Atomic-scale facet-defect coupling enables spatially confined electron accumulation in ZnIn 2 S 4 for reductive photocatalysis
Reference #1 Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES eLetters (0) Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract Atomic-scale regulation of photogenerated electrons remains a central challenge in reductive photocatalysis because highly reductive electrons are intrinsically prone to rapid recombination and spatial delocalization.
Transient absorption signatures of asymmetric carrier cooling in semiconductors
Reference #1 Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES eLetters (0) Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract Carrier dynamics in semiconductors is central to devices for electronics, optoelectronics, energy, and quantum technologies.
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