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Articles by Christopher Flatley
Cesarean section and the gestational duration of subsequent pregnancies: A nationwide register-based cohort study
Citation: Evers F, Flatley C, Ytterberg K, Juodakis J, Solé-Navais P, Jacobsson B (2025) Cesarean section and the gestational duration of subsequent pregnancies: A nationwide register-based cohort study. PLoS ONE 20(2): e0317492. https://doi.org/10.1371/journal.pone.0317492 Editor: Jin Young Nam, Eulji University, REPUBLIC OF KOREA Received: February 5, 2024; Accepted: December 20, 2024; Published: February 5, 2025 Copyright: © 2025 Evers et al.
Endometriosis‐Related Genetic Factors and Their Role in Preterm Birth: A Two‐Sample Mendelian Randomisation Study
Objective Endometriosis affects 10% of women worldwide and is linked to adverse pregnancy outcomes, including preterm birth. Recent epidemiological and genetic studies indicate that endometriosis may influence gestational duration and the likelihood of preterm birth.
Genome-wide analyses of neonatal jaundice reveal a marked departure from adult bilirubin metabolism - Nature Communications
Abstract Jaundice affects almost all neonates in their first days of life and is caused by the accumulation of bilirubin. Although the core biochemistry of bilirubin metabolism is well understood, it is not clear why some neonates experience more severe jaundice and require treatment with phototherapy. Here, we present the first genome-wide association study of neonatal jaundice to date in nearly 30,000 parent-offspring trios from Norway (cases ≈ 2000).
Genome-wide association meta-analysis identifies five loci associated with postpartum hemorrhage - Nature Genetics
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Abstract Bleeding in early pregnancy and postpartum hemorrhage (PPH) bear substantial risks, with the former closely associated with pregnancy loss and the latter being the foremost cause of maternal death, underscoring the severe impact on maternal–fetal health. We identified five genetic loci linked to PPH in a meta-analysis.
By David Westergaard, Valgerdur Steinthorsdottir, Palle Duun Rohde, Xiaoping Wu, Frank Geller, Pol Sole-Navais, Christopher Flatley, Ole Birger Pedersen, Christian Erikstrup, Christina Mikkelsen, Mie Topholm Bruun, Thorsten Brodersen, Per C. Magnus, Ole A. Andreassen, Pål Njolstad, Lone Krebs, Mette Nyegaard, Thomas Hansen, Bjarke Feenstra, Gudmar Thorleifsson, Olafur A. Stefansson, Gardar Sveinbjornsson, Daniel F. Gudbjartsson, Bo Jacobsson, Triin Laisk, Hannele Laivuori, Søren Brunak, Nordic Collaboration
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Nature
Verified
Author Correction: Characterization of the genetic architecture of infant and early childhood body mass index - Nature Metabolism
Correction to: Nature Metabolism https://doi.org/10.1038/s42255-022-00549-1, published online 21 March 2022. In the version of the article initially published, there were errors in Supplementary Table 1 where the values in the age column were incorrectly ordered (the values for Q3 were substituted for the values of Q1). The corrected Supplementary Table 1 has now been uploaded. This was an error in formatting and has no implications for the analyses, results or conclusions of the paper.
Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth - Nature Genetics
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Abstract A well-functioning placenta is essential for fetal and maternal health throughout pregnancy. Using placental weight as a proxy for placental growth, we report genome-wide association analyses in the fetal (n = 65,405), maternal (n = 61,228) and paternal (n = 52,392) genomes, yielding 40 independent association signals. Twenty-six signals are classified as fetal, four maternal and three fetal and maternal. A maternal parent-of-origin effect is seen near KCNQ1.
By Robin Beaumont, Christopher Flatley, Marc Vaudel, JING CHEN, Gunn-Helen Moen, Line Skotte, Øyvind Helgeland, Pol Sole-Navais, Karina Banasik, Clara Albiñana, Justiina Ronkainen, Katerina Trajanoska, David Westergaard, Sundararajan Srinivasan, José Ramón Bilbao, Catherine Allard, Teemu Kuulasmaa, Frédérique White, Haoxiang Cheng, Ke Hao, Ole A. Andreassen, Bjørn Olav Åsvold, Ben Michael Brumpton, Søren Brunak, Jonas Bybjerg-Grauholm, Paul Elliott, Christian Erikstrup, Marisa Estarlich Estarlich, Frank Geller, Jakob Grove, David M. Hougaard, Eero Kajantie, Mette Nyegaard, Ole Birger Pedersen, Fernando Rivadeneira, Sylvain Sebert, Camilla Stoltenberg, Bjarni J Vilhjálmsson, Cristen J. Willer, Timo A Lakka, Torben Frøstrup Hansen, Ewan R Pearson, Sisse R. Ostrowski, Craig E Pennell, Janine F. Felix, Andrew T. Hattersley, Deborah A. Lawlor, Thomas Werge, Henriette Svarre Nielsen, David Evans, Bo Jacobsson, Marjo-Riitta Järvelin, Marie-France Hivert, Stefan Johansson, Rachel M Freathy, Bjarke Feenstra, Marika Groleau, Dorte Gybel-Brask
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Nature
Verified
FLASHOVER AND BACKDRAFT: A Primer
BY CHRISTOPHER FLATLEY Flashover and backdraft have been confused for years. Part of the reason for the confusion is that they produce a very similar result-a large fire that envelops the whole room or area. They are, however, very different in how and why they occur. RELATED Flashover! A Near Miss During a Vent-Enter-Search Do You Know All That You Need to Know About Flashover?
Development of a cross‐validated model for predicting emergency cesarean for intrapartum fetal compromise at term
Abstract Objectives To develop a model for predicting emergency cesarean for fetal distress (ECFD) at term using a combination of maternal and late pregnancy ultrasound parameters measured at more than 36 gestational weeks. Methods A study of prospectively collected data, including ultrasound scans at 36–38 weeks, for singleton non‐anomalous deliveries at Mater Mother's Hospital, Brisbane, Australia, between January 2010 and April 2017.
Reduced growth velocity at term is associated with adverse neonatal outcomes in non-small for gestational age infants
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. Fig. 1 Predicted mean change of estimated fetal weight by gestational age in weeks for the adverse neonatal outcome ANO: adverse neonatal outcome. Fig.
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