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Articles by Chuan Lan
Pharmacological activation of WASp potentiates macrophage phagocytosis and enhances ibrutinib efficacy against mouse models of brain tumors
Editor’s summary Penetrating the blood-brain barrier and activating the immune system are two main barriers of current therapies to treat primary and metastatic brain malignancies. Here, Cheng et al. evaluate repurposing ibrutinib, a blood-brain barrier penetrating the tyrosine kinase inhibitor (TKI) to target and activate its effect on tumor-associated macrophages (TAMs).
Lupus Vulgaris
Ayuda Buscar en la ayuda Buscar en la ayuda Lupus Vulgaris Wang, Chuan-Peng [1] ; Zhou, Jia [1] [1] MD Localización: JAMA Dermatology, ISSN 2168-6068, Vol. 161, Nº. 9, 2025, págs. 970-971 Idioma: inglés Enlaces Texto completo Resumen A woman in her 60s presented with progressive facial lesions over 10 years. Initially, swelling appeared on her right cheek with erythematous, brown papules gradually merging into asymptomatic plaques. The lesions expanded to involve the right lower jaw and chin.
Long-range cholinergic input promotes glioblastoma progression
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Keywords glioblastoma rabies virus neuro-glioma interaction diagonal band of Broca cholinergic input glutamatergic input neural circuit manipulation CHRM3 scopolamine donepezil Get full text access Log in, subscribe or purchase for full access. References 1. Mancusi, R. ∙ Monje, M. The neuroscience of cancer Nature. 2023; 618:467-479 2. Winkler, F. ∙ Venkatesh, H.S. ∙ Amit, M. ... Cancer neuroscience: State of the field, emerging directions Cell. 2023; 186:1689-1707 3.
By Chuanyan Yang, Xuezhu Chen, Yibin Jiang, Xuejiao Lei, Kang Ma, Yulian Quan, Tianran Li, Chenfu Guo, Yijing Meng, Lin Kang, Xinyu Zhang, Long Jin, Jiafeng Huang, Ning Mu, Zexuan Yan, Qinghua Ma, Shuai Wang, Yanxia Wang, Yong-Ning Shang, Cong Chen, Yu Shi, Shukun Hu, Likun Yang, Chuan Lan, Rong Hu, Ying Zhang, Xia Li, Yunqing Li, Chong Liu, Yu-Hai Wang, Hua Feng, Xiu-Wu Bian, Tunan Chen
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Cell Press
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Hepatic epithelioid hemangioendothelioma-a single-institution experience with 51 cases
Introduction Hepatic epithelioid hemangioendothelioma (HEHE) is a low-to-moderate malignant tumor (1) ranging in malignancy between hepatic hemangioma (HHA) and hepatic hemangiosarcoma (HAS) (2), with a reported incidence of 1–2 for every 1 million people (3). Clinically, HEHE presents as an incidental finding at the time of diagnosis with symptoms ranging from nonspecific to liver failure at advanced stage (4).
The prognostic biological markers of immunotherapy for non-small cell lung cancer: current landscape and future perspective
1 Introduction Lung carcinoma is widely acknowledged as being the foremost reason for mortality connected to neoplasms in both the U.S. and China, which is with around 85% of pulmonary neoplasms classified as non-small cell lung carcinomas (NSCLCs) (1, 2).
Non-coding RNA in tumor-infiltrating regulatory T cells formation and associated immunotherapy
1 Introduction Immunotherapy for cancer has become the most promising approach in recent years (1). Therapeutic drugs and cellular therapies derived from immunotherapy have extended the lives of patients with advanced cancer. Among them, immune checkpoint inhibitors (ICIs), also known as co-inhibitory receptors (CIRs), are the most well-known treatment strategy.
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