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Articles by Cong Ma
Mathematics > Statistics Theory
We establish dimension-free comparison inequalities between the Kullback-Leibler (KL) and $χ^2$-divergences and the squared Hellinger distance for Gaussian location mixtures with compactly supported mixing distributions. We show that both divergences are bounded by the squared Hellinger distance up to constants depending only on the radius of the support, independently of the ambient dimension and the number of mixture components.
Efficacy and safety of Yangxin Dingji capsule as an adjunctive therapy for atrial fibrillation: a systematic review and meta-analysis of randomized controlled trials
Abstract Background: Yangxin Dingji Capsule (YXDJ), a modern Chinese patent medicine derived from the classic Zhigancao Decoction, is commonly used as an adjuvant therapy for atrial fibrillation (AF). This study aimed to comprehensively evaluate the efficacy and safety of YXDJ as an adjuvant therapy in AF patients.
Targeting lysine acetyltransferase 6A/B in cancer: a conceptual and translational review of epigenetic regulation, immune microenvironment remodeling, and the dual-compartment hypothesis
Abstract While lysine acetyltransferase 6A (KAT6A; MOZ/MYST3) and 6B (KAT6B; MORF/MYST4) function as context-dependent oncogenic drivers—with KAT6B also displaying tissue-specific tumor-suppressive roles—their pharmacological targeting holds promise as a therapeutic avenue.
Statistics > Machine Learning
[Submitted on 27 Sep 2026 (v1), last revised 13 Oct 2026 (this version, v2)] View PDF HTML (experimental) Subjects: Machine Learning (stat.ML); Information Theory (cs.IT); Machine Learning (cs.LG); Statistics Theory (math.ST) Cite as: arXiv:2609.33291 [stat.ML] (or arXiv:2609.33291v2 [stat.ML] for this version) https://doi.org/10.48550/arXiv.2609.33291
Field evaluation of spray drift exposure and phytotoxic effects on non-target crops from UAV and conventional sprayers
1 INTRODUCTION Pesticides remain indispensable for protecting crops from weeds, insects and diseases, and therefore play a vital role in sustaining agricultural productivity and global food security. However, pesticide applications rarely achieve complete on-target deposition because environmental conditions and application practices promote spray drift, the unintended movement of droplets beyond the treated area.
Cyclin-Dependent Kinases 4 and 6 Inhibitors: An Emerging Therapeutic Framework from Growth Suppression to Tumor Clearance Click to copy article link Article link copied!
Domain I: Targeted Senescence Clearance/Senolytics +BH3 mimetics (e.g., navitoclax, A-1331852) broad solid tumors early clinical (navitoclax)/preclinical (A-1331852) TIS markers (BCL-2, BCL-xL amp) targets acquired antiapoptotic dependency to selectively trigger mitochondrial apoptosis overlapping hematological toxicity (neutropenia/thrombocytopenia); mandatory staggered dosing during treatment holidays +D + Q broad solid tumors preclinical active Src kinases, HIF-1α suppresses Src family and...
Trans-Glasso: A Transfer Learning Approach to Precision Matrix Estimation
Abstract Precision matrix estimation is essential in various fields, yet it is challenging when samples for the target study are limited. Transfer learning can enhance estimation accuracy by leveraging data from related source studies. We propose Trans-Glasso, a two-step transfer learning method for precision matrix estimation. First, we obtain initial estimators using a multi-task learning objective that captures both shared and unique features across studies.
Calcium-sensitive synaptotagmin 11-lipid interaction modulates exo-endocytosis - Nature Communications
Abstract Synaptotagmins (Syts) are the primary Ca2+-sensors for synaptic vesicle exocytosis, while most mammalian Syts are non-Ca2+-affinitive and play critical roles in neurotransmission and synaptic plasticity with unclear mechanisms. Here, we show that high-alkaline non-Ca2+-binding Syt11 exhibits higher affinity for acidic phospholipids and Ca2+-inhibited liposome-binding, thereby competing with the Ca2+-binding Syt1.
Munc18 modulates syntaxin phase separation to promote exocytosis - Nature Neuroscience
Abstract The soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protein syntaxin mediates neuronal exocytosis and self-assembles into large clusters in the plasma membrane. The formation and function of these clusters, and whether they promote or inhibit synaptic-vesicle fusion, remain unclear.
Spatial patterns of glioblastoma
Get full text access Log in, subscribe or purchase for full access. References 1. Migliozzi, S. ∙ Adabbo, B. ∙ Garofano, L. ... Restraint of cancer cell plasticity by spatial homotypic clustering Cancer Cell. 2025; 43:2206-2223.e10 2. Price, M. ∙ Ballard, C. ∙ Benedetti, J. ... CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2017–2021 Neuro Oncol. 2024; 26:vi1-vi85 3. Verhaak, R.G.W. ∙ Hoadley, K.A. ∙ Purdom, E. ...
Association of 25-hydroxyvitamin D with sex hormones and body composition in Chinese older adults
1 Introduction Vitamin D deficiency is a significant public health issue, with a high prevalence among older adults (>60 years old). Epidemiological studies have demonstrated that the global prevalence of vitamin D deficiency (defined as a serum 25-(OH)D level < 20 ng/mL) among older adults is as high as 58.7% to 90.3% (1–3). Therefore, the series of systemic changes and health issues associated with vitamin D deficiency in the elderly population deserves attention.
Enantioselective Synthesis of Atropisomeric 3-Arylindoles via Cobalt-Catalyzed Electroreductive Cross-Coupling
Cite Jump to ExpandCollapse CommunicationOctober 2, 2025 Enantioselective Synthesis of Atropisomeric 3-Arylindoles via Cobalt-Catalyzed Electroreductive Cross-Coupling Click to copy article linkArticle link copied! Shi-Shuo Xu Shi-Shuo Xu State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200032, P. R.
Optimising the Design of Implantable Fuel Cells
This version is not peer-reviewed. Cong Ma,Elizabeth Gibson,Mirella Di Lorenzo,Patrick Degenaar * Cong Ma,Elizabeth Gibson,Mirella Di Lorenzo,Patrick Degenaar * Submitted: 02 September 2025 Posted: 02 September 2025 You are already at the latest version As the world's population ages, the incidence of chronic disorders is on the rise. Active Implantable Medical Devices are therefore evolving to meet the challenge.
Tetrandrine regulates NAADP-mediated calcium signaling through a LIMP-2-dependent and sphingosine-mediated mechanism - Nature Communications
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Abstract Tetrandrine (Tet) is a potent inhibitor of Ebola virus replication by blocking NAADP-dependent calcium release through endolysosomal two-pore channels (TPCs) and a moderately potent anti-tumor agent. Using a clickable photoaffinity probe, we identify lysosomal integral membrane protein-2 (LIMP-2) as a direct target of Tet and a key regulator of this calcium signaling. Tet binds LIMP-2’s ectodomain, inhibiting lysosomal cholesterol and sphingosine transport, which alters lipid metabolism.
By Wing-Cheung Chan, Qian Zhao, Koon Ho Wong, Hok-Him Tang, Lakhansing Pardeshi, Ye Ruan, Chi-Ming Wong, Yong-Juan Zhao, Ka Ying Chan, Xiyang Ma, Mary Chau, Franco King-Chi Leung, Kailei Sun, Chin Yu Mok, Fang Wang, Cong Ma, Yu-Hin Ho, Xiang-Yang Ye, Yajing zhang, Yan Zhao, Xiang Li, Gary M Tse, Xiao Shen
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Additive effect of atherogenic index of plasma and social determinants of health on all-cause and cardiovascular mortality in U.S. adults with diabetes and prediabetes
Data availability All data analyzed during this study are publicly available on the NHANES website at https://www.cdc.gov/nchs/nhanes/index.htm. References 1. Zhang, Q. ∙ Xiao, S. ∙ Jiao, X. ... The triglyceride-glucose index is a predictor for cardiovascular and all-cause mortality in CVD patients with diabetes or pre-diabetes: evidence from NHANES 2001-2018 Cardiovasc Diabetol. 2023; 22:279 2. Ma, C. ∙ Yu, R. ∙ Li, J. ...
Tocilizumab for Non-Infectious Uveitis: A Review
Back to Journals » Journal of Inflammation Research » Volume 18 Authors Cao H , Bian K , Ma C, Zhang N , Ma X Received 20 May 2025 Accepted for publication 9 September 2025 Published 20 September 2025 Volume 2025:18 Pages 13117—13138 DOI https://doi.org/10.2147/JIR.S533011 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Justin Jacob Haixing Cao,* Kaiyu Bian,* Cong Ma, Naiwen Zhang, Xiang Ma Department of...
Transition-Metal Free Photocatalytic Synthesis of Acylsulfonamides
Acylsulfonamides are fundamental scaffolds in pharmaceutical development due to their broad range of biological activities. (1) They are widely recognized as bioisosteres of carboxylic acid groups, attributed to their similar acidity and resistance to chemical and enzymatic hydrolysis. In addition to serving as direct drug motifs, acylsulfonamide scaffolds are extensively utilized in solid-phase peptide synthesis (2) and as acylating agents for amines.
Transition-Metal Free Photocatalytic Synthesis of Acylsulfonamides
Acylsulfonamides are fundamental scaffolds in pharmaceutical development due to their broad range of biological activities. (1) They are widely recognized as bioisosteres of carboxylic acid groups, attributed to their similar acidity and resistance to chemical and enzymatic hydrolysis. In addition to serving as direct drug motifs, acylsulfonamide scaffolds are extensively utilized in solid-phase peptide synthesis (2) and as acylating agents for amines.
Spatial Pattern and Socioeconomic Factors of 2022 Monkeypox Outbreak in the United States
Abstract The 2022 global outbreak of monkeypox (mpox) exhibited unprecedented characteristics and transmission dynamics that diverged from historical outbreaks of the disease. This study presents the first county-level spatial analysis of the 2022 mpox outbreak across five U.S. states. We employed spatial and statistical analyses to quantify the spatial patterns of the mpox infection rate and its relations with various socioeconomic and environmental variables.
[2503.12045] Auditing Differential Privacy in the Black-Box Setting
arXiv:2503.12045 (stat) [Submitted on 15 Mar 2025 (v1), last revised 10 Apr 2025 (this version, v2)] View PDF HTML (experimental) Comments: Subjects: Methodology (stat.ME); Cryptography and Security (cs.CR); Machine Learning (cs.LG) Cite as: arXiv:2503.12045 [stat.ME] (or arXiv:2503.12045v2 [stat.ME] for this version) https://doi.org/10.48550/arXiv.2503.12045 Submission history From: Kaining Shi [ view email] [v1] Sat, 15 Mar 2025 08:34:40 UTC (48 KB) [v2] Thu, 10 Apr 2025 18:44:33 UTC (48...
Recent Advances in Asymmetric Organometallic Electrochemical Synthesis (AOES)
Abstract Click to copy section linkSection link copied! Conspectus In recent years, our research group has dedicated significant effort to the field of asymmetric organometallic electrochemical synthesis (AOES), which integrates electrochemistry with asymmetric transition metal catalysis. On one hand, we have rationalized that organometallic compounds can serve as molecular electrocatalysts (mediators) to reduce overpotentials and enhance both the reactivity and selectivity of reactions.
Recent Advances in Asymmetric Organometallic Electrochemical Synthesis (AOES)
Abstract Click to copy section linkSection link copied! Conspectus In recent years, our research group has dedicated significant effort to the field of asymmetric organometallic electrochemical synthesis (AOES), which integrates electrochemistry with asymmetric transition metal catalysis. On one hand, we have rationalized that organometallic compounds can serve as molecular electrocatalysts (mediators) to reduce overpotentials and enhance both the reactivity and selectivity of reactions.
Deacetylated SNAP47 recruits HOPS to facilitate autophagosome-lysosome fusion independent of STX17 - Nature Communications
Abstract Autophagy, a conserved catabolic process implicated in a diverse array of human diseases, requires efficient fusion between autophagosomes and lysosomes to function effectively. Recently, SNAP47 has been identified as a key component of the dual-purpose SNARE complex mediating autophagosome-lysosome fusion in both bulk and selective autophagy. However, the spatiotemporal regulatory mechanisms of this SNARE complex remain unknown.
Scalable deoxygenative alkynylation of alcohols via flow photochemistry - Communications Chemistry
Abstract Internal alkynes are often contained in bioactive pharmaceuticals and crucial intermediates in material sciences, yet their production methods are often limited and challenging, necessitating the development of more efficient and versatile synthetic routes. Here we report a method of deoxygenative alkynylation of alcohols via flow photochemistry. Formation of N-heterocyclic carbene-alcohol adducts undergoes oxidation by a photocatalyst, generating alkyl radicals.
Deep Learning with Evolutionary Scale Modeling to discover Antibiotic-Resistance Drug against Klebsiella Pneumoniae
Abstract The development of effective antibiotics is crucial in combating antibiotic-resistant pathogens such as Klebsiella pneumoniae (KP). This study utilizes deep learning, specifically Evolutionary Scale Modeling (ESM), to identify potential drug candidates. By analyzing molecular similarities between known drugs and KP strains, we aim to accelerate the discovery of new treatments and reduce the risks associated with clinical trials.
Polymers | Free Full-Text | Study on the Polymer Morphology and Electro-Optical Performance of Acrylate/Epoxy Resin-Based Polymer-Stabilized Liquid Crystals Based on Stepwise Photopolymerization
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Ordering Sulfonic Groups Facilitate a Li3N‐Enriched Interphase via Directing the Decomposition of LiNO3
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm202406479-sup-0001-SuppMat.docx25.4 MB Supporting Information References 1, , , , , , , , , , Small 2023, 19, 2207742. 2a) , , , , , , , , , , Energy Environ. Sci. 2021, 14, 4115; b) , , , , , , , , Energy Storage Mater. 2024, 65, 103124. 3a) , , Adv. Energy Mater. 2017, 7, 1700732; b) , , , , , , , , Adv. Funct. Mater. 2021, 31, 2006159; c) , , , , , , , J. Power Sources 2011, 196, 9839.
Enhanced Electro‐Optical and Heat Regulation of Intelligent Dimming Films Using the Photovoltaic Effect of p-n Heterostructures
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm202406858-sup-0001-SuppMat.pdf777.9 KB Supporting Information References 1, , , , , , Energy Convers Manag 2020, 213, 112868. 2, , , , , , , Adv. Mater. 2015, 27, 2489. 3, , , Appl. Energy 2012, 94, 270. 4, , , , , , , , , , Nat. Mater. 2016, 15, 1267. 5, , , Nano Energy 2015, 12, 258. 6, , , , , ACS Appl. Mater. Interfaces 2014, 6, 9118. 7, , , Adv. Mater. 2020, 32, 2003574. 8, , , , Adv. Opt. Mater.
Bioinspired Aerogels: Ingenious Structure, Remarkable Performance, and Versatile Applications
Bioinspired Aerogels: Ingenious Structure, Remarkable Performance, and Versatile Applications The amazing qualities of biomaterials are the result of billions of years of evolution. Normally, biomaterials are formed in moderate environments with a restricted supply of components available for living organisms. The exquisite hierarchical structures play an important role in the surprising properties of these materials.
The roles of exosomes in regulating hair follicle growth
Introduction Alopecia is considered a widespread yet troubling health issue, which could be categorized primarily into nonscarring (non-cicatricial) alopecia and scarring (cicatricial) alopecia.1 Clinically, the most prevalent forms of alopecia are androgenetic alopecia (AGA) and alopecia areata (AA).1 AGA impacts 70% of males and 50% of females by 50 years old,1 with AA’s lifetime occurrence around 2% globally.2,3 As a common disease, alopecia affects not only patients’ appearance, but also...
Towards Building a Faster and Incentive Enabled Privacy-Preserving Proof of Location Scheme from GTOTP
1. Introduction Location-based services (LBSs) have gained significant prominence in recent years [1] due to the widespread adoption of mobile devices [2] and advancements in location-based technologies. In LBSs, users leverage location-based technologies to share their locations with location service providers (SPs) in order to access location-dependent services and resources such as location-based social networks (LBSN) [3], location-based assistive technology [4], and fitness monitoring.
Inferring allele-specific copy number aberrations and tumor phylogeography from spatially resolved transcriptomics
Abstract A key challenge in cancer research is to reconstruct the somatic evolution within a tumor over time and across space. Spatially resolved transcriptomics (SRT) measures gene expression at thousands of spatial locations in a tumor, but does not directly reveal genetic aberrations. We introduce CalicoST, an algorithm to simultaneously infer allele-specific copy number aberrations (CNAs) and a spatial model of tumor evolution from SRT of tumor slices.
Highly Luminescent and Stable Perovskite Quantum Dots Films for Light‐Emitting Devices and Information Encryption
Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request.
In situ transmission electron microscopy (TEM) study on the structural evolution behavior of nano Sn sheets under a thermal field
In situ transmission electron microscopy (TEM) study on the structural evolution behavior of nano Sn sheets under a thermal field† Sn-based solders have been used widely in chip attachment and surface mount processes in the electronic packaging industry, where Sn plays an indispensable role as the main component of Sn-based solders. However, the application of pure Sn as a solder is limited.
A Triply‐Periodic‐Minimal‐Surface Structured Interphase based on Fluorinated Polymers Strengthening High‐energy Lithium Metal Batteries
Conflict of interests The authors declare no conflict of interest. Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
A Smart Window with Passive Radiative Cooling and Switchable Near-Infrared Light Transmittance via Molecular Engineering
RETURN TO ARTICLES ASAPPREVApplications of Poly...Applications of Polymer, Composite, and Coating MaterialsNEXT Cong Ma School of Materials Science and Engineering, Peking University, Beijing 100083, China , Zuowei Zhang Beijing Advanced Innovation Center for Materials Genome Engineering, Institute for Advanced Materials and Technology, University of Science and Technology Beijing, Beijing 100083, China , Yihai Yang School of Materials Science and Engineering, Peking University, Beijing...
Wetting Behavior of CO2-H2O-coal with Different Metamorphic Degrees under In Situ Thermophysical Conditions
Download Hi-Res ImageDownload to MS-PowerPointCite This:Energy Fuels 2024, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
Mediating Zn Ions Migration Behavior via β-Cyclodextrin Modified Carbon Nanotube Film for High-Performance Zn Anodes
Download Hi-Res ImageDownload to MS-PowerPointCite This:Nano Lett. 2024, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
Microstructure and Water Vapor Barrier Performance of Organic‐bridged Polysilsesquioxane/Carbon Quantum Dots Composite Coatings
Corresponding Author Ce Zhang Key Laboratory of Auxiliary Chemistry and Technology for Chemical Industry, Ministry of Education, College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xi’an, 710021 China Shaanxi Collaborative Innovation Center of Industrial Auxiliary Chemistry and Technology, Institute of Frontier Science and Technology Transfer, Shaanxi University of Science and Technology, Xi’an, 710021 China Search for more papers by this author
Degradation Mechanisms of Six Typical Glucosidic Bonds of Disaccharides Induced by Free Radicals
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Degradation Mechanisms of Six Typical Glucosidic Bonds of Disaccharides Induced by Free Radicals
Increasing hydrogen peroxide (H2O2)-based systems have been developed to degrade various polysaccharides due to the presence of highly reactive free radicals, but published degradation mechanisms are still limited. Therefore, this study aimed to clarify the degradation mechanism of six typical glucosidic bonds from different disaccharides in an ultraviolet (UV)/H2O2 system.
Security Protection of 3D Models of Oblique Photography by Digital Watermarking and Data Encryption
1. Introduction With the rapid development of oblique photogrammetry technology based on unmanned aerial vehicle (UAV), 3D models of oblique photography (3DMOP) are playing an increasingly significant role in the establishment of digital cities [1,2] and twin watersheds [3], due to their huge advantages such as high accuracy, clear texture information, virtual simulation capability, etc. Despite their significant utility, the security issues they face are becoming increasingly prominent [4].
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