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Articles by Dan Du
Acne: epidemiology, risk factors, pathogenesis, management and cutting-edge research
Abstract Acne vulgaris is a widespread chronic inflammatory skin condition particularly affecting the pilosebaceous unit, with its pathogenesis intricately linked to excessive sebum production, abnormal follicular keratinization, overcolonization by Cutibacterium acnes (C. acnes), and dysregulated host immune responses.
Author Correction: YAP maintains the dynamics of TDP-43 condensates and antagonizes TDP-43 pathological aggregates
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Correction to: Nature Cell Biology https://doi.org/10.1038/s41556-025-01685-y, published online 20 June 2025. In the version of the article initially published, in the left panel of Fig. 5g and the accompanying source data, several values in the “3A” column were duplicated from the “WT HeLa” column. In the legend to Fig. 1g, the recovery-stage cell number for the YAP−/− + YAP WT group should have been “691” rather than “619”, and in the legend to Fig.
By Jiaqi Zhang, Jiaojiao Hu, Ruogu Liu Verified, Tian Zhou, Xuewei Luo, Peigang Liang, Qinyue Zhao, Yan Chen, Dan Du, Cong Liu, Yiming Zheng, Dan Li, Bo Wang, Zaichao Xie
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Nature
Verified
NAT10-mediated ac 4 C acetylation of PPFIA4 mRNA drives papillary thyroid carcinoma progression and lymph node metastasis by rewiring focal adhesion signaling
Abstract Thyroid cancer, predominantly papillary thyroid carcinoma (PTC), has become the fastest-growing malignancy in terms of incidence rate. RNA epitranscriptomic modifications such as N4-acetylcytidine (ac4C) play crucial roles in cancer progression, yet their function in PTC remains unclear. This study demonstrates that NAT10 and ac4C levels are upregulated in PTC and correlate with lymph node metastasis. The transcription factor ATF2, highly expressed in PTC, drives NAT10 upregulation.
Investigation of the ABO gene as a biomarker in breast invasive carcinoma using cancer profiling and blood type distribution
Abstract Introduction: Invasive breast carcinoma (BRCA) is one of the leading causes of cancer‑related mortality in women worldwide, highlighting the urgent need for novel prognostic biomarkers. The ABO gene has recently been implicated in various cancers. This study comprehensively investigated the expression pattern, clinical significance, and potential molecular mechanisms of ABO in BRCA.
Differential clinical impact of HLA-DPA1~DPB1 linkage mismatches in 14/14-matched unrelated donor HSCT: a multicenter retrospective study from CMDP revealing age- and disease-specific risk patterns
Optimal HLA matching is critical for allogeneic hematopoietic stem cell transplantation (HSCT) outcomes [1]. Guidelines for donor selection underscore the clinical significance of HLA-DPB1 for post-transplant outcomes [2, 3]. However, the independent and combined impacts of HLA-DPA1 mismatches, especially in linkage with DPB1, remain understudied.
Drynachromoside A from Drynaria fortunei attenuates oxidative stress and fibrosis of diabetic nephropathy via activating Nrf2 in vitro and in vivo
ABSTRACT Background: Diabetic nephropathy (DN) is the most common complication of diabetes mellitus. It has shown that the activation of nuclear factor erythroid 2-related factor 2 (Nrf2) could attenuate DN. To identifiy novel Nrf2 activators targeting DN, we explored drynachromoside A (DCSA) from Drynaria fortunei in vitro and in vivo. Methods: To determine the effects of DCSA, the proliferation of mesangial cells induced by high glucose was evaluated.
Emerging 2D Materials and Their Hybrid Nanostructures for Label‐Free Optical Biosensing: Recent Progress and Outlook
1 Introduction Nowadays, growing public concern about healthcare and environmental conditions has driven rapid advancements in biosensor technologies, particularly those delivering high sensitivity, fast response, and real-time monitoring capabilities.[1-6] Based on the type of transducer, biosensors are classified into three major categories[7]: electrochemical, physical, and optical (Figure 1).
YAP maintains the dynamics of TDP-43 condensates and antagonizes TDP-43 pathological aggregates - Nature Cell Biology
Abstract Recent studies exploring the underlying pathomechanisms of amyotrophic lateral sclerosis (ALS), a fatal motor neuron disorder, have focused on biomolecular condensates. Here we reveal an unexpected function for YAP, a central component of the Hippo pathway, in regulating the dynamic behaviour of stress granules and TDP-43 condensates, a role that is independent of its transcriptional activity in the Hippo pathway. YAP directly binds to TDP-43.
A Csde1-Strap complex regulates plasma cell differentiation by coupling mRNA translation and decay - Nature Communications
Abstract Upon encountering antigens, B cells may undergo multiple differentiation paths, including becoming plasma cells and memory B cells. Although it is well-known that transcription factors govern gene expression programs underpinning these fate decisions in transcriptional level, the role of post-transcriptional regulators, with a focus on RNA-binding proteins, in the fate determination are lesser known.
Hypoxia-inducible factor 2α promotes pathogenic polarization of stem-like Th2 cells via modulation of phospholipid metabolism
Keywords Th2 scRNA sequencing HIF2α stem-like memory T cells pathogenic Th2 asthma Th2 heterogeneity HIF2α inhibitor CUT&Tag IPMK Introduction CD4+ T helper (Th) cells play pivotal roles in orchestrating immune responses to protect the organism from disease. Upon activation, naive CD4+ T cells differentiate into various effector subsets, each controlled by signature transcription factors (TFs) induced by cytokines and T cell receptor (TCR) signaling.
Role of Sphingosine-1-Phosphate Signaling Pathway in Pancreatic Diseases
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Role of S1P Signaling Pathway in Pancreatic Diseases
Preprint Review Version 1 This version is not peer-reviewed Version 1 : Received: 9 October 2024 / Approved: 9 October 2024 / Online: 10 October 2024 (06:19:14 CEST) Fu, F.; Li, W.; Zheng, X.; Wu, Y.; Du, D.; Han, C. Role of S1P Signaling Pathway in Pancreatic Diseases. Preprints 2024, 2024100672. https://doi.org/10.20944/preprints202410.0672.v1 Fu, F.; Li, W.; Zheng, X.; Wu, Y.; Du, D.; Han, C. Role of S1P Signaling Pathway in Pancreatic Diseases. Preprints 2024, 2024100672.
Differences in the Clinical Characteristics of Male Patients With Different Ages of Rosacea: A Retrospective Study of 215 Male Outpatients
1 Introduction Rosacea is a chronic inflammatory condition primarily affecting the central facial region [1]. Clinical manifestations in patients may include flushing, persistent erythema, papules, pustules, phymatous changes, burning, and edema, with some patients also experiencing ocular symptoms [2, 3]. The pathogenesis of rosacea has not been fully elucidated, and factors such as temperature, emotions, diet, and lifestyle changes are believed to exacerbate symptoms [4].
Evaluating the therapeutic effect of LIPUS in the early stage of traumatic brain injury using FA and T2* in rats | Aging
Research Paper Volume 16, Issue 15 pp 11744—11754 1 Department of Magnetic Resonance Imaging, Qinhuangdao Municipal No. 1 Hospital, Qinhuangdao, China 2 Department of Radiology, Peking University Third Hospital, Beijing, China 3 Institute of Medical Technology, Peking University Health Science Center, Beijing, China https://doi.org/10.18632/aging.206060 How to Cite Cite this Article Select the format you require from the list below Click to copy this citation from the text box above or...
How does the ion concentration affect the functions of kinesin BimC
Abstract BimC family proteins are bipolar motor proteins belonging to the kinesin superfamily which promote mitosis by crosslinking and sliding apart antiparallel microtubules. Understanding the binding mechanism between the kinesin and the microtubule is crucial for researchers to make advances in the treatment of cancer and other malignancies. Experimental research has shown that the ion concentration affects the function of BimC significantly.
Improvement of PBFT Consensus Algorithm Based on Affinity Propagation Clustering in Intellectual Property Transaction Scenarios
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Progressive Optimal Fault-Tolerant Control Combining Active and Passive Control Manners
1. Introduction In industrial systems, fault diagnosis (FD) and fault-tolerant control (FTC) are closely related. In recent years, there have been many studies on fault diagnosis and fault-tolerant control in various fields, including aerospace [1,2,3] and fields associated with power systems [4,5,6], high-speed rail systems [7,8,9,10,11], and satellites [12,13]. Based on previous research, fault diagnosis will inevitably develop in a faster and more accurate way in the future.
Progressive Optimal Fault-Tolerant Control Combining Active and Passive Control Manners
Preprint Article Version 1 This version is not peer-reviewed Version 1 : Received: 15 March 2024 / Approved: 15 March 2024 / Online: 15 March 2024 (12:10:49 CET) Du, D.; Li, Z.; Dahhou, B. Progressive Optimal Fault-Tolerant Control Combining Active and Passive Control Manners. Preprints 2024, 2024030920. https://doi.org/10.20944/preprints202403.0920.v1 Du, D.; Li, Z.; Dahhou, B. Progressive Optimal Fault-Tolerant Control Combining Active and Passive Control Manners. Preprints 2024, 2024030920.
The Preparation of Acryloxyl Group Functionalized Siloxane Polymers and the Study of Their Ultra Violet Curing Properties
1. Introduction Traditional silicone materials are primarily prepared through thermal curing. The preparation process has problems, such as high energy consumption, long time, and cumbersome operations [1].
Bound ion effects: Using machine learning method to study the kinesin Ncd’s binding with microtubule
Significance Ions are crucial for biomolecular interactions, especially for highly charged biomolecules. Bound ion effects are difficult to study in implicit solvent models. Based on the machine learning approach, we have developed a hybrid solvent method to combine the explicit solvent model with the implicit solvent model to study protein-protein interactions. Such a hybrid approach treats the bound ions explicitly and the free ions implicitly.
Atomic-level design of metalloenzyme-like active pockets in metal-organic frameworks for bioinspired catalysis
Atomic-level design of metalloenzyme-like active pockets in metal–organic frameworks for bioinspired catalysis Natural metalloenzymes with astonishing reaction activity and specificity underpin essential life transformations. Nevertheless, enzymes only operate under mild conditions to keep sophisticated structures active, limiting their potential applications.
Atomic-level design of metalloenzyme-like active pockets in metal-organic frameworks for bioinspired catalysis
Atomic-level design of metalloenzyme-like active pockets in metal–organic frameworks for bioinspired catalysis Natural metalloenzymes with astonishing reaction activity and specificity underpin essential life transformations. Nevertheless, enzymes only operate under mild conditions to keep sophisticated structures active, limiting their potential applications.
ChatGPT 3.5 in responding to patients' queries about rosacea
Sihan Yan,1,2,* Dan Du,1,2,* Xu Liu,1,2 Yingying Dai,1,2 Min-Kyu Kim,1,2 Xinyu Zhou,3 Lian Wang,1,2 Lu Zhang,1,2 Xian Jiang1,2 1Department of Dermatology, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 2Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 3Department of Dermatology, Nanbu...
Novel Biotin-linked Amphiphilic Calix[4]arene-based Supramolecular Micelles as Doxorubicin Carriers for Boosted Anticancer Activity
Novel Biotin-linked Amphiphilic Calix[4]arene-based Supramolecular Micelles as Doxorubicin Carriers for Boosted Anticancer Activity The lacking of targeting, and severe toxic and side effects on normal tissues has become an intractable limitations of doxorubicin (DOX)-based chemotherapy. To tackle these drawbacks, supramolecular carrier-mediated chemotherapy is a highly attractive strategy for targeted drug delivery.
Density, Viscosity, and Vapor Pressure of 1,1,3,5,5-Pentamethyl-3-phenyltrisiloxane, 3-(Dimethylsilyloxy)-1,1,5,5-tetramethyl-3-phenyltrisiloxane, and 1,1,5,5-Tetramethyl-3,3-diphenyltrisiloxane
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Chem. Eng. Data 2024, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
New Media Integration Self-Management Support Model, Rosacea
Back to Journals » Patient Preference and Adherence » Volume 17 Authors Liu X , Kim MK , Du D , Zhou X, Wang L, Jiang X Received 23 July 2023 Accepted for publication 22 September 2023 Published 27 September 2023 Volume 2023:17 Pages 2395—2400 DOI https://doi.org/10.2147/PPA.S431955 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Jongwha Chang Xu Liu,1,2,* Min-Kyu Kim,1,2,* Dan Du,1,2 Xinyu Zhou,1,2 Lian...
Efficacy and safety of macitentan for pulmonary hypertension: A meta-analysis
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Efficacy and safety of macitentan for pulmonary hypertension: A meta‐analysis
ORIGINAL ARTICLE Funding information: There was no funding source for the study. Prospero registration: CRD42022338965. Abstract Introduction Our purpose of this study is to evaluate the effect and safety of macitentan in the treatment of pulmonary hypertension (PH). Methods We retrieved the safety and efficacy of macitentan treatment for PH using PubMed, the Cochrane Library, EMBASE databases and clinicaltrials.gov.
The Use of Compost Tea in a Containerized Urban Tree Nursery Shows No Evident Benefits to Tree Growth or Mycorrhizal Colonization
Abstract : Compost tea is a liquid organic amendment that has been reported to benefit plant growth and performance through positive effects on microbial communities and plant nutrition. However, few studies have demonstrated this for containerized plants produced in tree nurseries.
Non-destructive diagnostic testing of Cardiac Myxoma by serum confocal Raman micro-spectroscopy Combined with Multivariate analysis
Non-destructive diagnostic testing of Cardiac Myxoma by serum confocal Raman micro-spectroscopy Combined with Multivariate analysis Qiang Chen, Tao Shi, Dan Du, Bo Wang, Sha Zhao, Yang Gao, Shuang Wang and Zhanqin Zhang Abstract The symptoms of cardiac myxoma (CM) mainly occur when the tumor is growing, and the diagnosis is determined by clinical presentation. Unfortunately, there is no evidence that specific blood tests are useful in CM diagnosis.
The small GTPase Arf6 is dysregulated in a mouse model for fragile X syndrome
Abstract Fragile X syndrome (FXS), the most common inherited cause of intellectual disability, results from silencing of the fragile X mental retardation gene 1 (FMR1). The analyses of FXS patients’ brain autopsies revealed an increased density of immature dendritic spines in cortical areas. We hypothesize that the small GTPase Arf6, an actin regulator critical for the development of glutamatergic synapses and dendritic spines, is implicated in FXS.
Association between genetic polymorphism and antidepressants in major depression: a network meta-analysis
Dan Du‡ Department of Psychiatry, Laboratory of Neurological Diseases & Brain Function, Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan Province, China , Qiong Tang‡ Department of Psychiatry, Laboratory of Neurological Diseases & Brain Function, Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan Province, China , , Jin Zhang Department of Psychiatry, Laboratory of Neurological Diseases & Brain Function, Affiliated Hospital of Southwest...
Development of a clinical decision support system for severity risk prediction and triage of COVID-19 patients at hospital admission: an international multicentre study
Guangyao Wu, Pei Yang, Yuanliang Xie, Henry C.
Efficacy and safety of Telbivudine and Tenofovir disoproxil fumarate in preventing hepatitis B vertical transmission: a real‐life practice
Original Paper Efficacy and safety of Telbivudine and Tenofovir disoproxil fumarate in preventing hepatitis B vertical transmission: a real‐life practice Jinfeng Liu Department of Infectious Diseases, the First Affiliated Hospital, Xi'an JiaotongUniversity, Xi'an, Shaanxi Province, China, 710061 Jinfeng Liu and Jing Wang contributed equally to this work and share first authorship Search for more papers by this author Jing Wang Department of Rheumatology and Immunology, the First Affiliated...
Small hepatitis delta antigen selectively binds to target mRNA in hepatic cells: a potential mechanism by which hepatitis D virus downregulates glutathione S-transferase P1 and induces liver injury and hepatocarcinogenesis
Mianzhi Chen,*a Dan Du,*a Wen Zheng,a Mingheng Liao,b Lu Zhang,a Ge Liang,a Meng Gonga aHuaxi-Washington Mitochondria and Metabolism Research Center, West China Hospital, Sichuan University, Chengdu 610041, China. bDepartment of Liver Surgery, West China Hospital, Sichuan University, Chengdu 610041, China. Received December 5, 2017. Accepted August 23, 2018. Abbas Z, Afzal R. 2013. Life cycle and pathogenesis of hepatitis D virus: a review. World J. Hepatol.
Recent Advances in Electrochemical Immunosensors
Citation data is made available by participants in Crossref's Cited-by Linking service. For a more comprehensive list of citations to this article, users are encouraged to perform a search inSciFinder. Yanling SongBingqian LinTian TianXing XuWei WangQingyu RuanJingjing GuoZhi ZhuChaoyong Yang Analytical Chemistry 2018 Article ASAP Ricardo A. G. de OliveiraCaroline Y. N. NicolicheAnielli M. PasqualetiFlavio M. ShimizuIris R. RibeiroMatias E. MelendezAndré L. CarvalhoAngelo L. GobbiRonaldo C. FariaRenato S.
Ultrathin Dendritic IrTe Nanotubes for Efficient Oxygen Evolution Reaction with a Wide pH Range
The shape control of Ir-based nanostructured materials, which are considered as the state-of-the-art anode electrocatalyst candidates toward oxygen evolution reaction (OER), has been rarely reported. Here, we reported the efficient synthesis of ultrathin dendritic IrTe nanotubes (NTs) via galvanic displacement reaction using Te nanowires as the template at 190 °C for 1 h.
Angewandte Chemie International Edition
Recent years have witnessed a dramatic increase in the production of sustainable and renewable energy. However, the electrochemical performances of the various systems are limited, and there is an intensive search for highly efficient electrocatalysts by more rational control over the size, shape, composition, and structure.
Recent progress in nanomaterials for gene delivery applications
Nanotechnology-based gene delivery is the division of nanomedicine concerned with the synthesis, characterization, and functionalization of nanomaterials to be used in targeted-gene delivery applications. Nanomaterial-based gene delivery systems hold great promise for curing fatal inherited and acquired diseases, including neurological disorders, cancer, cardiovascular diseases, and acquired immunodeficiency syndrome (AIDS). However, their use in clinical applications is still controversial.
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