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Articles by Daniel Erny
Distinct postnatal trajectories of mouse dendritic epidermal T cells and Langerhans cells independent of microbiota
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract The mouse epidermis harbors two key resident immune populations—dendritic epidermal T cells (DETCs), a subset of invariant γδ T cells, and Langerhans cells (LCs), specialized tissue-resident macrophages—both of which play critical roles in immune surveillance, barrier integrity,...
Bacterial infection reshapes monocyte and macrophage ontogeny at the CNS borders
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Editor’s summary Abstract Supplementary Materials REFERENCES AND NOTES Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Editor’s summary Meningeal macrophages contribute to central nervous system (CNS) homeostasis and immune responses, but how infection shapes their development and function remains unclear. Using a mouse model of streptococcal meningoencephalitis, Gres et al.
By Natsumi Takayama, Sachin Bhagchandani, Vitka Gres, Florens Lohrmann, Vidmante Fuchs, Jana Neuber, Zohreh Mansoori Moghadam, Anne K. Lösslein, Lance F. P. Bosch, Tiago Figueiral-Martins, Sebastian Baasch, David Obwegs, Gianni Monaco, Julia Henschel, Klaus P. Knobeloch, Marco Prinz, Steffen Jung, Katrin Kierdorf, Julia Kolter, Daniel Erny, Philipp Henneke
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Science Magazine
Verified
Subcellular orchestration of microglial aging
Microglial morphology can indicate functional states in aging and age-related diseases, yet subcellular transcriptional organization remains poorly understood. Combining multiplexed error-robust fluorescence in situ hybridization (MERFISH) with fluorescent immunohistochemistry, Henze et al.
A transcriptomic microglia taxonomy across mouse and human pathologies
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Abstract Single-cell studies have revealed substantial microglial diversity in development, homeostasis and disease. However, a framework enabling comparison and stratification of microglial states across contexts is needed. Here we generated an atlas of myeloid cell states by single-cell RNA sequencing more than one million central nervous system cells from more than 30 physiological and pathological conditions.
By Chintan Chhatbar, Roman Sankowski, Michael Schulz, Takashi Shimizu, Marius Schwabenland, Ori Staszewski, Christian Scheiwe, Katharina Borst, Anaelle Aurelie Dumas, Wesley Brandao, Omar Mossad, Adrià Dalmau Gasull, Maximilian Frosch, Daniel Erny, Martin Diebold, Janaki Manoja Vinnakota, Koliane Ouk, Inken Waltl, Michael LaMorte, Timothy R. Hammond, Giovanni Di Liberto, Ilena Vincenti, Mario Kreutzfeldt, Ibrahim T Mughrabi, Yousef Al-Abed, Thomas Blank, Melanie Meyer-Luehmann, Yanick J. Crow, Dimitry Ofengeim, Robert Zeiser, Jutta Gärtner, Andreas Meisel, Martin Schwemmle, Ulrich Kalinke, Jürgen Beck, Bertram R Bengsch, Robert Thimme, Oleg Butovsky, Tamara Seredenina, Richard M. Ransohoff, Francisco J. Quintana, Katrin Kierdorf, Doron Merkler, Christine Stadelmann, Josef Priller, Marco Prinz, Stefan Nessler, Ella Trost, Daniel Berchtold, Elena Guffart, Katharina Ternka, Mihaela Guranda, Marina Friesen, Nellwyn Hagen, Matthias Kettwig
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Nature
Verified
T-bet+ CXCR3+ B cells drive hyperreactive B-T cell interactions in multiple sclerosis
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Keywords multiple sclerosis IFN-gamma T cells autoreactivity T-bet+ B cells CXCR3 hyperreactive B-T cell interaction B-T cell-enriched clusters BTEC self-peptides autoproliferation meninges Introduction Multiple sclerosis (MS) is an autoimmune disease of the CNS, in which pro-inflammatory autoreactive CD4+ T cells are considered major effector cells in orchestrating damaging immune responses.1,2 We recently demonstrated that they engage in tight interactions with memory B cells resulting in...
By Ivan Jelcic, Reza Naghavian, Will Macnair, Cinzia Esposito, Daniela Calini, Yanan Han, Catarina Raposo, Pietro Oldrati, Daniel Erny, Veronika Kana, Galina Zheleznyakova, Faiez Al Nimer, Björn Tackenberg, Ina Reichen, Mohsen Khademi, Fredrik Piehl, Mark Robinson, Ilijas Jelcic, Mireia Sospedra, Lucas Pelkmans, Dheeraj Malhotra, Richard Reynolds, Maja Jagodic, Roland Martin Verified, Imran Fanaswala, Zoe Marti
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Cell Reports Medicine
Verified
Mesoscopic Assessment of Microstructure in Glioblastomas and Metastases by Merging Advanced Diffusion Imaging with Immunohistopathology
Mesoscopic Assessment of Microstructure in Glioblastomas and Metastases by Merging Advanced Diffusion Imaging with Immunohistopathology Urs Würtemberger, Daniel Erny, Alexander Rau, Jonas A. Hosp, Veysel Akgün, Marco Reisert, Valerij G. Kiselev, Jürgen Beck, Sonja Jankovic, Peter C. Reinacher, Marc Hohenhaus, Horst Urbach, Martin Diebold, Theo Demerath American Journal of Neuroradiology Oct 2023, DOI: 10.3174/ajnr.A8022
Gut microbiota drives age-related oxidative stress and mitochondrial damage in microglia via the metabolite N6-carboxymethyllysine - Nature Neuroscience
Abstract Microglial function declines during aging. The interaction of microglia with the gut microbiota has been well characterized during development and adulthood but not in aging. Here, we compared microglial transcriptomes from young-adult and aged mice housed under germ-free and specific pathogen-free conditions and found that the microbiota influenced aging associated-changes in microglial gene expression.
Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease
Amit I. Winter D.R. Jung S. The role of the local environment and epigenetics in shaping macrophage identity and their effect on tissue homeostasis. Nat. Immunol. 2016; 17: 18-25 Andrews, S. (2019). FastQC: a quality control tool for high throughput sequence data. Babcock A.A. Ilkjær L. Clausen B.H. Villadsen B. Dissing-Olesen L. Bendixen A.T. Lyck L. Lambertsen K.L. Finsen B. Cytokine-producing microglia have an altered beta-amyloid load in aged APP/PS1 Tg mice. Brain Behav. Immun.
Microvascular Alterations in Alzheimer's Disease
Preface Many drugs developed to treat Alzheimer's disease (AD) have been designed on the assumption that amyloid beta (Aβ) drives the disease. This approach has not yielded FDA-approved drugs, with approved medications such as cholinesterase inhibitors or memantine (glutamate blocker) only treating symptoms of AD. Proponents of the Amyloid Hypothesis (AH) feel that anti-Aβ therapies may have been administered too late in the disease process, and that the AH remains valid.
Gut-brain axis
This Collection is editorially independent, produced with financial support from a third party. About this content. Host microbiota constantly control maturation and function of microglia in the CNS In this study, the authors show that host microbiota play a key role in modulating microglia homeostasis. Germ-free mice or mice with only limited microbiota complexity displayed defects in microglial cell proportions and maturation, leading to impaired innate immune responses.
Erratum: Ontogeny and homeostasis of CNS myeloid cells
In the version of this article initially published, some of the arrows along the right side of Figure 1 were incorrect. The arrow from 'Ly6Chi monocyte' to 'pvM? long-living' should be deleted, and an arrow should be added from 'Ly6Chi monocyte' into the boxed area above (top right). The error has been corrected in the HTML and PDF versions of the article.
Communicating systems in the body: how microbiota and microglia cooperate
Microglia are tissue macrophages of the central nervous system (CNS). Their key tasks are immune surveillance as well as responding to infections or other pathological states such as neurological diseases or injury. In recent years it has been discovered that microglia are additionally crucial for the maintenance of brain homeostasis during development and adulthood by adjusting the neuronal network and phagocytosing neuronal debris.
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