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Editor’s summary Cancer survivors treated with chemotherapy often have long-term side effects, but how chemotherapy affects the heart is not well understood. In mouse models, He et al. found that DNA-damaging chemotherapies such as carboplatin induce cardiac-resident macrophage cell death via apoptosis and necroptosis, which led to repopulation by recruited monocytes.
Abstract Acute kidney injury (AKI) is a frequent complication in critically ill patients and triggers a systemic inflammatory response that can contribute to lung injury, ultimately worsening clinical outcomes. However, diagnostic and therapeutic strategies remain unavailable. In this issue of the JCI, Komaru et al. explored leukocyte trafficking and vascular pooling following AKI in mice as an underlying mechanism of acute lung injury.
Keywords macrophages transplantation heart TREM-1/3 CCR2 Research topic(s) CP: Immunology Introduction Cardiac transplantation remains the ultimate treatment for patients with end-stage heart disease.1 Myocardial ischemia-reperfusion injury (IRI) is a form of sterile inflammation that is of major clinical significance as it adversely impacts both short- and long-term outcomes.
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