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Articles by Daniel Traum
Spatial atlas of diabetic kidney disease reveals a B cell-rich subgroup
Abstract Diabetic kidney disease (DKD), the leading cause of kidney failure, is marked by clinical and molecular heterogeneity, making therapeutic development exceedingly difficult1. Here we used Xenium and CosMx single-cell spatial transcriptomics, integrated with single-nucleus RNA sequencing, to build a cross-platform kidney atlas that makes tissue architecture computable for prognosis, non-invasive detection and patient selection.
Virus-associated inflammation imprints an inflammatory profile on monocyte-derived macrophages in the human liver
Abstract Chronic liver injury triggers the activation and recruitment of immune cells, causing antigen-independent tissue damage and liver disease progression. Tissue inflammation can reshape macrophage composition through monocyte replacement. Replacement of tissue macrophages with monocytes differentiating in an inflammatory environment can potentially imprint a phenotype that switches the liver from an immune-tolerant organ to one predisposed to tissue damage.
Single-cell multi-omic and spatial profiling of human kidneys implicates the fibrotic microenvironment in kidney disease progression - Nature Genetics
Abstract Kidneys are intricate three-dimensional structures in the body, yet the spatial and molecular principles of kidney health and disease remain inadequately understood. We generated high-quality datasets for 81 samples, including single-cell, single-nuclear, spot-level (Visium) and single-cell resolution (CosMx) spatial-RNA expression and single-nuclear open chromatin, capturing cells from healthy, diabetic and hypertensive diseased human kidneys.
Virus-associated Inflammation Imprints an Inflammatory Profile on Long-lived Monocyte-derived Macrophages in the Human Liver
Abstract Chronic liver injury triggers the activation and recruitment of immune cells, causing antigen-independent tissue damage and liver disease progression. Tissue inflammation can reshape macrophage composition through monocyte replacement. Replacement of tissue macrophages with monocytes differentiating in an inflammatory environment can potentially imprint a phenotype that switches the liver from an immunotolerant organ to one predisposed to tissue damage.
Single-cell analysis of the human pancreas in type 2 diabetes using multi-spectral imaging mass cytometry
Highlights • Imaging mass cytometry profiles of the T2D pancreas with 34 antibodies • There is a relative loss of beta and gain of alpha cells in the T2D pancreas • Advanced neighborhood analysis finds increased macrophage/beta cell contacts in T2D • Activated HLA-DR-positive CD8 T cells are enriched in the T2D islet Summary Type 2 diabetes mellitus (T2D) is a chronic age-related disorder characterized by hyperglycemia due to the failure of pancreatic beta cells to compensate for increased...
Multiplexed In Situ Imaging Mass Cytometry Analysis of the Human Endocrine Pancreas and Immune System in Type 1 Diabetes
Highlights • Imaging mass cytometry enables multiplexed histological analyses at 1-μm resolution • Islets are altered in architecture and composition during T1D progression • Islet cells show changes in protein expression during T1D progression • Immune cells are highly proliferative in T1D pancreata Summary The interaction between the immune system and endocrine cells in the pancreas is crucial for the initiation and progression of type 1 diabetes (T1D).
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