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Articles by David Lye
Cefazolin vs Cloxacillin for Methicillin-Susceptible S aureus Bacteremia : A Meta-Analysis of 2 Randomized Clinical Trials
Cefazolin vs Cloxacillin for Methicillin-Susceptible S aureus Bacteremia: A Meta-Analysis of 2 Randomized Clinical Trials Supplement 2. Figure. Forest Plots of Included Studies (opens in new tab) CloCeBa indicates Cloxacillin vs Cefazolin for Methicillin-Susceptible S aureus Bacteremia trial; CrI, credible interval; OR, odds ratio; SNAP, S aureus Network Adaptive Platform trial. Table.
Vertical Vaccination Against Infant Influenza Hospitalization in a Tropical Setting
Vertical Vaccination Against Infant Influenza Hospitalization in a Tropical Setting Supplement 1. eTable 1. Seasonal Influenza Vaccination Composition and Recommendations for Vaccination During Study Period (May 2017-April 2024) eTable 2. Estimates of Number-Needed-to-Vaccinate Against Influenza-Related Hospitalisations in Infants Under 6 Months eTable 3.
Risk of new-incident mental health diagnoses following SARS-CoV-2 infection amongst children and young adults in Singapore: a retrospective cohort study
Filename Description camh70112-sup-0001-Supinfo.docxWord 2007 document , 62.2 KB Table S1: New diagnoses of mental health disorders in Singaporean children, adolescents and young adults, measured in pre-pandemic period/pandemic phases. Table S2: Baseline characteristics of Singaporean children and young adults aged 6–25 years, stratified by test-negative and SARS-CoV-2 infected groups, with standardised-mean-differences before and after overlap weighting.
Utilising digital contact tracing during a pandemic to measure contact trends by risk group
Abstract Monitoring contact patterns is important for assessing impact of public-health-and-social-measures (PHSM) during a pandemic, but existing methods, such as contact surveys or mobility data, have limitations. While the COVID-19 pandemic provided impetus for population-wide adoption of digital-contact-tracing (DCT), prior studies that utilised DCT to evaluate contact patterns evaluated temporal variations, lacking granularity pertaining to impact in at-risk groups.
Optimizing mouse models for mRNA vaccines: addressing dose translation challenges
Abstract The development of mRNA vaccines has significantly advanced global health during the COVID-19 pandemic. However, translating effective vaccine doses from preclinical animal models to human clinical use remains poorly understood. In this study, we evaluated antibody responses and repertoire diversity across different BNT162b2 mRNA vaccine doses in mice, while comparing the results with human data through mathematical modeling.
The threat of another coronavirus pandemic: how are we preparing for it?
Merbecovirus is a subgenus within the genus Betacoronavirus that is genetically distinct from Sarbecovirus (eg, SARS-CoV-2). Recently, a few merbecoviruses isolated from the bat genus Pipistrellus were characterised and shown to have the ability to bind to angiotensin-converting enzyme 2 (ACE2) as an entry receptor.
Private Fleet Car Broker
Disclosure: Holding a full motor dealer’s licence, Private Fleet acts as a motor broker using our buying power and dealer relationships to save private buyers up to 25% off the price of new cars. All prices quoted include dealer delivery, stamp duty, CTP and registration as well as any other on-road costs. As a client you pay the dealer directly the agreed price and the dealer pays us a referral fee.
mRNA SARS-CoV-2 Vaccination Before vs During Pregnancy and Omicron Infection Among Infants
Key Points Question Is maternal vaccination associated with a lower risk of infection with Omicron SARS-CoV-2 variants, including XBB, among infants up to 6 months of age? Findings In this national population-based cohort study of 7292 infants aged 6 months or younger in Singapore, the estimated vaccine effectiveness in infants against Omicron SARS-CoV-2 variants, including XBB, from maternal messenger RNA (mRNA) SARS-COV-2 vaccination was 42%.
COVID-19 Severity and Waning Immunity After up to 4 mRNA Vaccine Doses in 73 608 Patients With Cancer and 621 475 Matched Controls in Singapore: A Nationwide Cohort Study | Global Health | JAMA Oncology | JAMA Network
Key Points Question How effective is COVID-19 vaccination in patients with cancer in protecting against severe disease and does protection wane over time? Findings In this nationwide cohort study including 73 608 patients with cancer and 621 475 matched controls, third and fourth vaccine doses were associated with incremental protection in both groups. No significant decrease in protection against severe disease was observed 5 months after the third and fourth vaccine dose.
BNT162b2 vaccine protection against omicron and effect of previous infection variant and vaccination sequence among children and adolescents in Singapore: a population-based cohort study
Summary Background Information on variant-specific vaccine protection and the effect of previous infection variant is scarce in children. We aimed to ascertain the level of protection conferred by BNT162b2 COVID-19 vaccination against omicron variant infection (BA.4 or BA.5, and XBB) in a previously infected national paediatric cohort. We also explored the association between sequence of previous infection (variant) and vaccination on protection.
Association of Homologous and Heterologous Vaccine Boosters With COVID-19 Incidence and Severity in Singapore
Reports of waning antibody levels and breakthrough infections among vaccinated individuals1 have prompted the recommendation for vaccine boosters to prevent SARS-CoV-2 infections. Despite more than 80% of the population in Singapore having received 2 doses of a COVID-19 vaccine, cases surged in September 2021 with the relaxation of social distancing and quarantine measures.
Pan-Sarbecovirus Neutralizing Antibodies in BNT162b2-Immunized SARS-CoV-1 Survivors
25 References 1 Citing Article Related Articles Summary Download a PDF of the Research Summary. Emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern pose a challenge to the effectiveness of current vaccines. A vaccine that could prevent infection caused by known and future variants of concern as well as infection with pre-emergent sarbecoviruses (i.e., those with potential to cause disease in humans in the future) would be ideal.
Lack of detail in population-level data impedes analysis of SARS-CoV-2 variants of concern and clinical outcomes
1 Davies NG Abbott S Barnard RC et al. Estimated transmissibility and impact of SARS-CoV-2 lineage B.1.1.7 in England. First reported in December 2020, in the UK, the variant's discovery coincided with a substantial surge in case numbers and fatalities in the UK, raising concerns that this variant was both more infectious and virulent than previous variants. Epidemiological and modelling studies have yielded good evidence that B.1.1.7 is more transmissible than other variants.
Safety of temporary interruption of antiplatelet therapy in dengue fever with thrombocytopenia
Highlights • Clinical decision to continue or interrupt antiplatelets did not affect mortality. • Temporary interruption of antiplatelets did not increase risk of thrombotic events. • Continuation of antiplatelets did not increase risk of blood transfusion, dengue haemorrhagic fever, or bleeding events. Summary Thrombocytopenia commonly occurs in dengue and may be complicated by bleeding. Dengue can occur in adults who may be on long term antiplatelet therapy for ischemic heart disease or stroke.
From SARS to COVID‐19: the Singapore journey
All countries must increase medical capabilities and adopt a concerted whole‐of‐government approach to combat COVID‐19 Singapore is a densely populated city‐state of 5.7 million and a global travel hub. These characteristics make it particularly susceptible to the importation of communicable diseases and consequent outbreaks.
Remdesivir for 5 or 10 Days in Patients with Severe Covid-19
24 References 193 Citing Articles Related Articles Abstract Background Remdesivir is an RNA polymerase inhibitor with potent antiviral activity in vitro and efficacy in animal models of coronavirus disease 2019 (Covid-19). Methods We conducted a randomized, open-label, phase 3 trial involving hospitalized patients with confirmed SARS-CoV-2 infection, oxygen saturation of 94% or less while they were breathing ambient air, and radiologic evidence of pneumonia.
Effect of Vancomycin or Daptomycin With vs Without an Antistaphylococcal β-Lactam on Mortality, Bacteremia, Relapse, or Treatment Failure in Patients With MRSA Bacteremia: A Randomized Clinical Trial | Critical Care Medicine | JAMA | JAMA Network
Effect of Vancomycin or Daptomycin With vs Without an Antistaphylococcal β-Lactam on Mortality, Bacteremia, Relapse, or Treatment Failure in Patients With MRSA Bacteremia: A Randomized Clinical Trial | Critical Care Medicine | JAMA | JAMA Network [Skip to Navigation] Visual Abstract. Vancomycin or Daptomycin With vs Without a β-Lactam and Clinical Outcome in Patients With MRSA Bacteremia Figure 1. Patient Recruitment, Randomization, and Flow Through the CAMERA2 Trial Figure 2.
The Fourth Industrial Revolution and Challenges for Government
Society February 2, 2017 David Lye Director and Fellow of Sami Consulting The Fourth Industrial Revolution will increasingly give citizens the ability to use technology to seek greater autonomy, which will challenge the power of government and institutions in disruptive ways. Photo: Spenser Platt/Getty Images Share this article Twitter Facebook LinkedIn Email Print Article The Fourth Industrial Revolution (4IR) confronts governments with a good news, bad news scenario.
How To Create 300 DPI Image Using Canva?
Image is a very important element to have when comes to online business. It is required in every side of the business such as in your social media channels, website and advertisements. So there is a need to create image from time to time and you can’t escape from this fact. Moreover, if your image is for Merch by Amazon or Kindle Direct Publishing (KDP) paperback, you’ll need to have 300 DPI image.
How to use your first business to launch your second
1. Being on the front line In my experience, most breakthroughs come from being on the front line, and that means engaging with customers, being hands-on with your clients, establishing a firm connection with them and understanding their needs. Use your daily experiences to constantly refine how you operate as a business to provide better service to your stakeholders. That specific accumulated knowledge will help you when looking to dive into a new venture. 2.
Outcomes of Fosfomycin Use in Ceftriaxone-Resistant Enterobacteriaceae Urinary Tract Infection in the Elderly
Publication HistoryPublished online: October 25, 2018Accepted: October 20, 2018; Received: February 12, 2018;
No association between resistance mutations, empiric antibiotic, and mortality in ceftriaxone-resistant Escherichia coli and Klebsiella pneumoniae bacteremia | Scientific Reports
We initially found a significant correlation between increased 30-day mortality and the number of beta-lactamase genes that confer third-generation cephalosporin resistance. The correlation seemed to be present when piperacillin-tazobactam was used but not with carbapenem, suggesting that carbapenems may be more stable in presence of multiple broad spectrum beta-lactamases. However, after adjusting for empiric carbapenem therapy, K.
Metformin Use and Severe Dengue in Diabetic Adults
The study included patients admitted to the Department of Infectious Diseases, Tan Tock Seng Hospital (TTSH), the largest university teaching hospital in Singapore in dengue treatment. The source population was identified from three previous hospital-based dengue studies conducted in TTSH in 200422, 2005–200823 and 2012–2013.
Medical and psychosocial factors associated with antibiotic prescribing in primary care: survey questionnaire and factor analysis
Research Tau-Hong Lee, Joshua GX Wong, David CB Lye, Mark IC Chen, Victor WK Loh, Yee-Sin Leo, Linda K Lee and Angela LP Chow British Journal of General Practice 2017; 67 (656): e168-e177. DOI: https://doi.org/10.3399/bjgp17X688885 Abstract Background Acute upper respiratory infections (AURI) are the leading causes of antibiotic prescribing in primary care although antibiotics are often not indicated.
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