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Articles by David Porteous
Genome-wide analysis of 439 mass spectrometry-based proteomic profiles in a population of 15,035 Scottish individuals
Abstract Understanding the genetic architecture of the circulating proteome can help determine if a protein is causally linked to disease. Previous large-scale genome-wide association studies of proteins have mostly been conducted on pre-defined, targeted subsets of the proteome, and have often concentrated on low-abundance proteins, many of which don’t exert their main function in serum.
No Digital Public Infrastructure Without Redress
Perspective David Porteous / Feb 26, 2026 David Porteous is the founder of Integral: Governance Solutions, a Boston-based advisory firm. This post represents his own views. An vendor sells vegetables at a roadside stall in Sabji Mandi Bazar in Delhi, receiving payment on UPI Unified Payments Interface Phonepe. Shutterstock Digital public infrastructure (DPI) has become the organizing concept for national digital transformation.
Genetic architecture reconciles linkage and association studies of complex traits - Nature Genetics
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Abstract Linkage studies have successfully mapped loci underlying monogenic disorders, but mostly failed when applied to common diseases. Conversely, genome-wide association studies (GWASs) have identified replicable associations between thousands of SNPs and complex traits, yet capture less than half of the total heritability.
By Julia Sidorenko, Kathryn E Kemper, Bjørn Olav Åsvold, Alireza Ani, Rujia Wang, Ilja M. Nolte, Scott Gordon, Caroline Hayward, Archie Campbell, Daniel Benjamin, David Cesarini, David Evans, David Porteous, Sarah E. Medland, Nicholas Martin, Harold Snieder, Andres Metspalu, Ben M Brumpton, Peter M. Visscher
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Nature
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Understanding Digital Public Infrastructure: What it Means - and Why it Matters - to Businesses and Governments in Emerging Markets
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Genetic insights into resting heart rate and its role in cardiovascular disease - Nature Communications
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Method details Populations The full RHR meta-analysis included 100 studies with data on RHR in up to 835,465 individuals. RHR was obtained from ECG in 54 studies, from pulse rate in 31 studies (of which seven were self-measured by the participants), from blood pressure monitor in nine studies, from electronic medical records in three studies, from manual measurement in one study and through a combination of multiple of the before mentioned methods in two studies.
By Yanick Hagemeijer, Albert Smith, Claudia Schurmann, Jennifer Brody, Gardar Sveinbjornsson, Cécile Lecoeur, Aaron Isaacs, Jian’an Luan, Anne Jackson, Lawrence F. Bielak, Maria Nethander, Wei Zhao, Carolina Roselli, Weihua Zhang, Marcus E Kleber, Raymond Noordam, Stella Trompet, Stefan Weiss, Xueling Sim, Ilja M. Nolte, Leo-Pekka Lyytikäinen, Lenore J. Launer, Susan M. Ring, Allan Linneberg, Bruce M. Psaty, Daniel F. Gudbjartsson, Hilma Holm, Beverley Balkau, Christopher Newton-Cheh, Patricia A. Peyser, Heribert Schunkert, Jari Lahti, Jennifer Smith, Maria Pina Concas, Thomas Meitinger, Melanie Waldenberger, Moritz F Sinner, Kent Taylor, Luisa Foco, Åsa Johansson, Peter K. Joshi, Peter W. Macfarlane, Kirill V. Tarasov, Harold Snieder, Johan Ormel, Andrew Morris, Torben Frøstrup Hansen, Themistocles L. Assimes, Vilmundur Gudnason, Nicholas J Timpson, Alanna C. Morrison, Patricia B Munroe, David P. Strachan, Niels Grarup, Susan R. Heckbert, Philippe Froguel, Leif Groop, Nicholas J Wareham, Mary F. Feitosa, Michael Boehnke, Jeanette Erdmann, Claes Ohlsson, David Porteous, Claude Bouchard Verified, Susanne Moebus, Peter Kraft, David R. Weir, Luigi Ferrucci, Giorgia Girotto, Adolfo Correa, Stefan Kääb, Annette Peters, Jaspal S Kooner, Jerome I. Rotter, Andrew Hicks, Ulf Gyllensten, James WIlson, James Wilson, Stephen Burgess, Johan Sundström, Wolfgang Lieb, J. Wouter Jukema, Ching-Yu Cheng, Marcus Dörr, Charumathi Sabanayagam, Albertine J. Oldehinkel, Terho Lehtimäki, Claes Ladenvall
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Nature
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Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease - Nature Communications
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Study cohorts Fourteen studies (32 ancestry-specific sub-studies) and 23 studies (40 ancestry-sub-studies) contributed GWAS summary statistics for spQRSTa and fQRSTa meta-analyses, respectively. These included members of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium60 (Supplementary Data 1). This study was approved by all participating cohorts. Ethics and consent was obtained at a study level.
By William Young, Jan-Walter Benjamins, Aaron Isaacs, Andrew Harper, Julia Ramirez, Sophie Garnier, Maria Pina Concas, Luisa Foco, Jonas L. Isaksen, Raymond Noordam, Negin Soroush, Stella Trompet, Alvaro Alonso, Álvaro Alonso Verified, Jennifer Brody, Archie Campbell, Adolfo Correa, Dawood Darbar, Jean-Francois Deleuze, Christina Ellervik, Christian Fuchsberger, Anuj Goel, Xiuqing Guo, Torben Frøstrup Hansen, Susan R. Heckbert, Allan Linneberg, Peter W. Macfarlane, Alanna C. Morrison, Pau Navarro, David Porteous, Peter P. Pramstaller, Lorenz Risch, Xia Shen, Gianfranco Sinagra, Elsayed Z. Soliman, Andrew Tinker, Helen R Warren, Eric A. Whitsel, Kerri L. Wiggins, Christy L. Avery, Giorgia Girotto, Niels Grarup, Caroline Hayward, J.Wouter Jukema, Morten Salling Olesen, Bruce M. Psaty, Cristian Pattaro, Niek Verweij, Michele Orini, Philippe Charron, Hugh Watkins, Charles Kooperberg, Henry Lin, James WIlson, James Wilson, Jørgen K. Kanters, Borbala Mifsud, Larisa G. Tereshchenko
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Nature
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The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions - Nature Genetics
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Author notes These authors jointly supervised this work: Stacey A. Missmer, Grant W. Montgomery, Andrew P. Morris, Krina T. Zondervan. Authors and Affiliations Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK Nilufer Rahmioglu, Michal Krassowski, Cecilia S. K. Cheuk, Cecilia M. Lindgren, Anne Ndungu & Krina T.
By Nilufer Rahmioglu, Peter L. Møller, Matthew Law, Yadav Sapkota, Sini Skarp, Ayush Giri, Karina Banasik, Michal Krassowski, Maarja Lepamets, Eeva Sliz, Gudmar Thorleifsson, Nura F. Topbas-Selcuki, David Westergaard, Archie Campbell, Todd L. Edwards, Reynir T. Geirsson, Jane E. Girling, Oskari Heikinheimo, Isabel C Hostettler, Henry Houlden, Sahar Houshdaran, Marjo-Riitta Järvelin, Yoichiro Kamatani, Stephen Kennedy, Johannes Kettunen, Michiaki Kubo, Hannele Laivuori, Massimo Mangino, Nicholas Martin, Alison Murray, Catherine M Olsen, Grzegorz Polak, David Porteous, Kathyrn M. Rexrode, Marcin Słomka, Blair Smith, Susan A. Treloar, Katy Vincent, David J. Werring, Eleftheria Zeggini, FinnGen Study, FinnGen Endometriosis Taskforce, Dharani K Hapangama, Caroline Hayward, Siew-Kee Low, Daniel I. Chasman, Marina Sirota, Tim Spector, David Whiteman, Outi Uimari, Peter Kraft, Andres Salumets, Dale R Nyholt, Reedik Mägi, Kari Stefansson, Christian Becker, Valgerdur Steinthorsdottir, Mette Nyegaard, Grant W. Montgomery, Andrew Morris
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Nature
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Inside the Beltway | Faegre Drinker Biddle & Reath LLP
Event Overview Please join us for our 43rd Inside the Beltway session on Thursday, February 16, 2023. Inside the Beltway is Faegre Drinker’s quarterly series of complimentary presentations on developments in Washington, D.C., that directly affect the benefits industry.
Long COVID burden and risk factors in 10 UK longitudinal studies and electronic health records - Nature Communications
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Abstract The frequency of, and risk factors for, long COVID are unclear among community-based individuals with a history of COVID-19. To elucidate the burden and possible causes of long COVID in the community, we coordinated analyses of survey data from 6907 individuals with self-reported COVID-19 from 10 UK longitudinal study (LS) samples and 1.1 million individuals with COVID-19 diagnostic codes in electronic healthcare records (EHR) collected by spring 2021.
By Ellen Thompson, Dylan Williams, Alex Walker, Ruth E. Mitchell, Claire L Niedzwiedz, Richard Silverwood Verified, Giorgio Di Gessa, Michael Green, Katie Doores, Emma Duncan, OpenSafely Collaborative, Andrew Steptoe, David Porteous, Laurie Tomlinson, Srinivasa Vittal Katikireddi, Kate Tilling, Christopher T. Rentsch, Nicholas J Timpson, Claire J Steves
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Nature
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SEC Examinations 2022 Priorities: Reg BI, ESG, Private Funds, Information Security & Operational Resiliency, and Crypto | JD Supra
The SEC Division of Examinations recently released its 2022 Division of Examinations “Priorities.” The 2022 Priorities provide critical insight into what the Division of Examinations (the “Division”) considers the most significant and highest potential risk areas for investors, and provides guidance for regulated entities on where to focus their compliance efforts.
Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals - Nature Genetics
Abstract We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a sample of ~3 million individuals and identify 3,952 approximately uncorrelated genome-wide-significant single-nucleotide polymorphisms (SNPs). A genome-wide polygenic predictor, or polygenic index (PGI), explains 12–16% of EA variance and contributes to risk prediction for ten diseases.
The SEC Sues Investment Advisory Firm in Connection with Alleged Failure to Disclose Revenue Sharing and Other Financial Conflicts, as Well as Converting Clients to Wrap Accounts Without Considering Whether it is in Clients’ Best Interests | Faegre Drinke
In recent years, the SEC has been conducting a nationwide and industry-wide “sweep” of investment advisory firms, pursuant to which it has opened investigations and brought enforcement actions against a multitude of investment advisory firms related to their disclosures and practices concerning revenue sharing and other alleged financial conflicts.1 We have previously blogged about litigated disclosure cases2 and given the fact that litigated decisions are the true test of enforcement...
The SEC Sues Investment Advisory Firm in Connection with Alleged Failure to Disclose Revenue Sharing and Other Financial Conflicts, as Well as Converting Clients to Wrap Accounts Without Considering Whether it is in Clients’ Best Interests
In recent years, the SEC has been conducting a nationwide and industry-wide “sweep” of investment advisory firms, pursuant to which it has opened investigations and brought enforcement actions against a multitude of investment advisory firms related to their disclosures and practices concerning revenue sharing and other alleged financial conflicts.1 We have previously blogged about litigated disclosure cases2 and given the fact that litigated decisions are the true test of enforcement...
SEC Proposes New Cybersecurity Risk Management Rules for Registered Investment Advisers and Funds | JD Supra
On Wednesday, the Securities and Exchange Commission announced proposed new cybersecurity risk management rules and amendments for investment advisers and investment companies. The proposed rules are designed to address concerns about advisers’ and funds’ cybersecurity preparedness and incident response in an effort to strengthen client and investor protection. The proposed rules include the following: Cybersecurity Risk Management Rules.
Ubiquitous Use of WhatsApp and Other Unrecorded Internal Communications Result in Substantial Penalties in Recent SEC, CFTC Actions | JD Supra
The SEC has, for many years, used broker-dealer and associated persons’ failure to create and maintain books and records as a basis for the imposition of serious penalties. In recent actions, it appears to be continuing—and upping the ante on—its enforcement in this area.
The Tortoise and the Hare: India and China Put Different Paths to Digital Finance to the Test
The Economist magazine carried a recent article which described the effects of the Universal Payment Interface (UPI) for Indian users of digital finance: “Money zips instantly from one bank account to the other, without any need to set up a pesky digital wallet or download some new app. At least outside China, there is no simpler way to shift money today.” Even a year ago, a favorable parallel like this between digital finance in India and China would have been unlikely.
SEC Chairman, Gary Gensler, Seeks to “Freshen Up” Restrictions on Executive Stock Trading Plans under Rule 10b5-1 | JD Supra
Upcoming Changes to Rule 10b5-1: The SEC is seeking to propose four key changes to executive stock trading plans under Rule 10b5-1 in October. Its Chairman, Gary Gensler, reported that the SEC is considering “freshen[ing] up Rule 10b5-1 after twenty years” to address insider trading concerns on June 7, 2021.
SEC “Sweep” of Public Companies’ & Registrants’ Responses to the SolarWinds Cyberbreach | JD Supra
As publicly reported late last week, the Securities and Exchange Commission’s Division of Enforcement (SEC) sent voluntary requests for information to a range of public companies and investment firms seeking voluntary disclosure of information related to last year’s SolarWinds cyberattack. Specifically, the SEC is seeking information related to whether the companies and firms were exposed to the SolarWinds cyberattack and any remedial measures the companies and firms implemented in response.
Chair Gensler Overhauls PCAOB | JD Supra
On Friday June 4, 2021, Securities and Exchange Commission Chair Gary Gensler removed the head of the Public Company Accounting Oversight Board (PCAOB), an independent agency created by the Sarbanes-Oxley Act of 2002 that is charged with setting standards and overseeing audits of public companies and broker-dealers.
SEC’s Director of Enforcement Unexpectedly Resigns Just Days after Taking the Job: Reminiscent of Previous Resignation by former Chairman Harvey Pitt | JD Supra
Alex Oh, U.S. Securities and Exchange Commission (SEC) Chair Gary Gensler’s pick for the agency’s Director of the Division of Enforcement, unexpectedly resigned on Wednesday amid growing criticism for her decades-long work as a private corporate defense lawyer. Ms. Oh’s hiring was announced on April 22, 2021, less than a week before her resignation. Ms. Oh’s resignation followed a ruling on Monday from Judge Royce C.
Comings & Goings at the SEC: Chair Gensler’s New Enforcement Director | JD Supra
On April 22, 2021, Ms. Alex Oh was named the new Director of the U.S. Securities and Exchange Commission’s (SEC) Division of Enforcement. Ms. Oh was most recently a partner in private practice where she served as co-chair of her law firm’s Anti-Corruption & FCPA Practice Group.
Speech by New Commissioner Provides Insight into Biden Administration SEC | JD Supra
As we await the impact of the Biden Administration on the direction of the SEC, we have been given a glimpse of what is to come in a speech last month by the newly confirmed commissioner, Caroline Crenshaw. Specifically, Commissioner Crenshaw’s speech focused on “individual culpability” and penalties in the SEC’s enforcement program.
SEC Enforcement Victory in its Efforts to Police Cannabis Industry Investments | JD Supra
As the cannabis industry continues to evolve and generate capital raising and investment opportunities, the SEC Division of Enforcement will continue to closely keep watch and target the bad actors that new market opportunities such as this inevitably and unfortunately attract. Along those lines, investors looking to purchase stock in supposed cannabis company, Covalent Collective, may have found vindication in the recent judgment against Geoffrey Thompson, of Frankfurt, Illinois.
Wrap Fee Programs Under Continued Scrutiny and Use of Investment Advisory Product Committees | JD Supra
Further to the Securities and Exchange Commission (“SEC” or the “Commission”)’s ongoing review of investment advisers offering wrap fee programs, on December 23, 2020, the Commission announced a settlement with Pruco Securities, LLC (“Pruco”) related to alleged breaches of fiduciary duty in connection with its wrap fee programs.
The Second Phase of the SEC’s Reg BI Exams
Closing out 2020, the SEC’s Division of Examinations (OCIE) issued a Statement on Recent and Upcoming Regulation Best Interest Examinations.
President Biden Announces Gary Gensler as SEC Chair Nominee | JD Supra
On January 18, 2021, the incoming President’s Transition Team announced additional key administration post nominees, including Mr. Gary Gensler as SEC Chair. The announcement specifically provided the following regarding Mr. Gensler’s background: Gary Gensler served as chairman of the U.S. Commodity Futures Trading Commission from 2009 to 2014, leading the Obama-Biden Administration’s reform of the $400 trillion swaps market.
Wrap Fee Programs Under Continued Scrutiny
Wednesday, January 20, 2021 Further to the Securities and Exchange Commission (“SEC” or the “Commission”)’s ongoing review of investment advisers offering wrap fee programs, on December 23, 2020, the Commission announced a settlement with Pruco Securities, LLC (“Pruco”) related to alleged breaches of fiduciary duty in connection with its wrap fee programs.
The SEC’s CCO Guidance Month | JD Supra
In a 30-day period, the U.S. Securities and Exchange Commission (“SEC”) has released guidance in three ways regarding certain views on the important role and potential liability risks of chief compliance officers (“CCOs”). SEC Commissioner Hester M.
What’s New, and Comings & Goings at the SEC | JD Supra
What’s New: The SEC’s Office of Compliance Inspections and Examinations (“OCIE”) recently issued a Risk Alert titled “Select COVID-19 Compliance Risks and Considerations for Broker-Dealers and Investment Advisers” on August 12, 2020.
COVID-19, the Brain, and Mental Health: Weighing the Direct and Indirect Effects
While COVID-19 is often thought of as primarily a respiratory disease, many neurological symptoms are present in those affected. Societal changes in response to the pandemic, such as social isolation and economic disruption, influence mental health. In this webinar, we will discuss recent findings on the direct and indirect implications of COVID-19 on the health and function of the nervous system.
SEC Enforcement Expanding Efforts Regarding Coronavirus Impacts | JD Supra
As we described several weeks ago, the SEC across the agency is going to be vigilant in its efforts to regulate, examine and enforce the federal securities laws regarding coronavirus/COVID-19. More recently, the SEC Division of Enforcement (“SEC Enforcement”) has stepped to the forefront of these efforts.
Genome-wide analysis identifies molecular systems and 149 genetic loci associated with income - Nature Communications
Using the UK Biobank data set, we identified 30 independent genetic loci (29 of which have not been previously reported) associated with income levels in Great Britain today. This represents a considerable advance on the two loci previously identified by Hill et al.7. The present study contributes to our understanding of the genetic contributions to SEP in at least seven major ways.
Digital Solutions Are Transforming Informal Workers into African iWorkers
The defining characteristic of most work in Africa is its informality: according to the ILO, 85% of work is done in the household, in smallholder agriculture or in unregistered businesses of all sizes. Why is Informal Work a Problem? First, let’s dismiss one spurious reason: informality is not a problem because of the nature of most of the work done in the informal sector.
Africa: What Will the Popularity of Online Shopping in Africa Mean for Jobs?
By David Porteous, Amolo Ng'weno Around the world, the new technologies behind digital commerce have reshaped the physical economy of goods and services, as well as employment. Digital commerce--or ecommerce, as it's still commonly known--has not only disrupted entire sectors like retail and travel, it has also undercut policy approaches to areas such as cross-border taxation. In this way, digital commerce is truly a double-edged sword.
What will the popularity of online shopping in Africa mean for
By DAVID PORTEOUS More by this Author By AMOLO NG'WENO More by this Author Around the world, the new technologies behind digital commerce have reshaped the physical economy of goods and services, as well as employment. Digital commerce—or ecommerce, as it’s still commonly known—has not only disrupted entire sectors like retail and travel, it has also undercut policy approaches to areas such as cross-border taxation. In this way, digital commerce is truly a double-edged sword.
What will the rise of online shopping in Africa mean for jobs?
Around the world, the new technologies behind digital commerce have reshaped the physical economy of goods and services, as well as employment. Digital commerce – or ecommerce, as it’s still commonly known – has not only disrupted entire sectors like retail and travel, it has also undercut policy approaches to areas such as cross-border taxation. In this way, digital commerce is truly a double-edged sword.
Mobile phones and other technology to increase access to finance
Mobile phones and other technology to increase access to finance This article is based on assessments of policy and regulation in seven countries - South Africa, Kenya, the Philippines, India, Pakistan, Russia and Brazil - where regulation of branchless banking targeted at the unbanked poor is still not fully formulated.
Rethinking Financial Inclusion Through Small Businesses and their Smartphones
How FIBR combines low-income customer’s relationships with local businesses, emerging data captured through smartphones, and a broader set of partners to deliver alternative linkages to financial services Financial Inclusion Started With Reaching the Underserved Financial inclusion began with the practical hypothesis of increasing access to financial services for the poor — by creating more opportunities for a direct relationship between financial institutions and low-income customers.
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