David Sauer
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Articles by David Sauer
Trump und Latinos: Warum Texas bei den Midterms wichtig ist
Die Angst vor der US-Einwanderungsbehörde ICE prägt den Alltag vieler Latinos in Texas. Zwischen Enttäuschung über die Republikaner und religiösen Überzeugungen wägen sie ihre Wahlentscheidung ab. 29.10.2026 | 2:48 min Wir sind unterwegs im Rio Grande Valley, im Süden von Texas. Als wir früher als verabredet auf einer Baustelle eintreffen, flüchten die Arbeiter ins Haus. Die Erleichterung ist groß, als sie merken: falscher Alarm. "Wir dachten, ihr wärt ICE-Agenten", sagt Bauleiter Benigno Melendez.
Midterms 2026: Wie die Demokraten gegen Trump gewinnen wollen
Donald Trump steht bei den Midterms nicht zur Wahl, doch sie sind ein Zwischenzeugnis für den Präsidenten. Laut Umfragen liefern sich Demokraten und Republikaner ein Kopf-an-Kopf-Rennen. 14.10.2026 | 7:11 min Mehr als 1.500 Menschen drängen sich an diesem Oktoberabend in Port Huron, Michigan. Normalerweise stehen die Menschen an der Halle nur für Eishockey Schlange. Heute wollen sie Abdul El-Sayed sehen, den demokratischen Kandidaten für den US-Senat.
High-resolution structures of human NHE6 and NHE9 elucidate endosomal ion and lipid interactions
Abstract Endosomal NHE6 (SLC9A6) and NHE9 (SLC9A9) transporters are essential for maintaining pH homeostasis within endosomes and their dysfunction has been linked to neurological and neurodegenerative disorders. NHE6 and NHE9 are widely considered to function as electroneutral exchangers that couple the export of protons to the import of sodium or potassium ions across cellular membranes, thereby forming the basis of proton leak pathways for internal pH balancing and fine-tuning.
Adapting to volatility: TP approaches for life sciences multinationals amid global uncertainty
For the global life sciences and healthcare sector – and, in particular, pharmaceutical and medtech companies within the life sciences subsegment – a striking duality can currently be observed: sustained confidence in firm-level performance alongside heightened uncertainty in the broader economic and geopolitical environment.
Structures of the human sodium-citrate cotransporter NaCT with and without substrates
Keywords sodium-substrate coupling citrate SLC13A5 cotransporter transporter dynamics Get full text access Log in, subscribe or purchase for full access. References 1. Sanders, F.W.B. ∙ Griffin, J.L. De novo lipogenesis in the liver in health and disease: more than just a shunting yard for glucose Biol. Rev. Camb. Philos. Soc. 2016; 91:452-468 2. Fang, M. ∙ Lowenstein, J.M. Citrate and the conversion of carbohydrate into fat. The regulation of fatty acid synthesis by rat liver extracts Biochem. J.
Rechenzentren: Das Surren, das Techbranche und US-Bürger entzweit
In den USA wächst der Widerstand gegen Datencentren. Für Konzerne wie Meta sind sie zwar unerlässlich, verbrauchen aber viel Energie und belasten das Grundwasser. 07.08.2026 | 2:59 min Das beschauliche Loudoun County ist etwa eine halbe Stunde vom Polittrubel in Washington entfernt. Eine ruhige, klassische Vorstadtgegend - nun, wäre da nicht manchmal dieses wahnsinnig laute Rasenmäher-Geräusch.
America Must Fight China’s Cultural Genocide
On July 1, 2026, China's new "Law on Promoting Ethnic Unity and Progress" went into effect after being passed by the National People's Congress. The name makes George Orwell's Ministry of Peace sound accurate. In truth, the law has nothing to do with unity or progress and everything to do with stamping out anyone who doesn't agree with Chinese totalitarianism.
SPNS2 exports sphingosine-1-phosphate and imports glucose
Abstract Spinster homolog 2 (SPNS2) exports the bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P) out of cells to regulate processes important for health and diseases. However, the molecular mechanism underlying SPNS2 transport functions and its precise physiological roles are not fully understood.
Amino acid and viral binding by the high-affinity Cationic Amino acid Transporter 1 (CAT1) from Mus musculus - Nature Communications
Abstract Arginine, lysine, and ornithine are critical to several fundamental aspects of organismal physiology, including protein structure and function, the urea cycle, and intracellular signaling. These cationic amino acids are imported by several membrane transporters, most notably the Cationic Amino acid Transporters (CATs) in the SLC7 family. Of these, CAT1 is also the receptor for two orthoretroviruses, and determines the host tropism for these viruses.
"Hier in Minneapolis lassen wir uns nicht einschüchtern“: Proteste wegen ICE-Razzien wachsen
Nach dem Tod einer Mutter in Minnesota durch einen ICE-Beamten steigt der Widerstand gegen Trumps Abschiebepolitik. Zehntausende Menschen sitzen in Abschiebezentren der Einwanderungsbehörde. 21.01.2026 | 13:28 min Trotz minus zehn Grad Celsius kommt William Kelly seit mehreren Wochen täglich zum ICE-Quartier in Minneapolis. Mit Cowboyhut und Warnweste ist der zwei Meter große Veteran den Beamten bereits bestens bekannt.
Zukunftsschau in der Wüste - CES 2026: Wenn der Lego-Stein mit KI denkt
In Las Vegas startet die renommierte Messe "Consumer Electronics Show". Auch deutsche Unternehmer reisen an, um einen Blick in die Zukunft der digitalen Welt zu werfen. 06.01.2026 | 1:39 min Das grelle Licht der Leuchtreklamen am Las Vegas Strip konkurriert diese Woche mit dem technologischen Feuerwerk, das in den Messehallen der CES gezündet wird. Die "Consumer Electronics Show" hat sich längst von einer reinen Gadget-Messe zu einem globalen Schauplatz für die Neuerfindung der Welt entwickelt.
Konflikt zwischen USA und Venezuela: Kriegsschiffe und wachsende Angst bei Exil-Venezolanern
Zehntausende Venezolaner leben in Doral bei Miami. Sie flüchteten wegen des venezolanischen Präsidenten Maduro in die USA. Doch dort will der US-Präsident sie schnell loswerden. 17.12.2025 | 6:38 min Es ist eine kurze Fahrt von den glitzernden Fassaden Miamis bis nach Doral, bekannt für den Golfclub des Präsidenten und Austragungsort des G20-Gipfels 2026. Doral ist aber auch Heimat der größten venezolanischen Gemeinde der USA. Vier von zehn Bewohnern kamen mal aus Venezuela.
How life sciences and healthcare companies deal with tariffs, disincen-tives, and grants
The global tax and regulatory environment is rapidly evolving, with significant implications for life sciences and healthcare (LSHC) companies. These businesses often operate complex, international value chains, making them especially vulnerable to changes in tax rules, tariffs, and other regulatory measures. One major development is the OECD’s pillar two framework, which introduces a global minimum tax for large multinationals.
Natur in Gefahr: Wie Trumps Sparpolitik Tourismus, Nationalparks und Gemeinden bedroht
Moab, ein kleines Wüstenstädtchen in Utah, ist das Tor zum Inbegriff amerikanischer Naturromantik. Als "Gateway Town" lebt der Ort vom Tourismus in die angrenzenden Nationalparks Arches und Canyonlands. Die ganze Region droht zum Spielball politischer Interessen zu werden - mit gravierenden Folgen für Mensch, Natur und Wirtschaft. Tourismus im Rückwärtsgang Lorenzo McGregor verdient seinen Lebensunterhalt mit Bootstouren auf dem Colorado River.
Nato-General: "Abschrecken - und Frieden wahren"
Die Nato-Einigung auf höhere Verteidigungsausgaben sei ein großer Sieg für Trump, sagt USA-Korrespondent David Sauer. Die spanische Ablehnung des Deals habe Trump allerdings empört.25.06.2025 | 11:21 min Auf dem Gipfel der Nato in Den Haag ist ein neues Ausgabenziel beschlossen worden: Künftig sollen jährlich fünf Prozent des Bruttoinlandsprodukts in Verteidigung fließen - 3,5 Prozent für klassische Militärbudgets, 1,5 Prozent für Infrastruktur und Sicherheit im weiteren Sinn.
For the People
I appreciate Jason Chiniche’s Letter to the Editor responding to my column. I thoroughly agree with him that we should all endorse “our most basic right” of Freedom of Speech. I’m glad we both agree that such vandalism as stealing signs should be deplored. But Jason gets at a deeper issue which is troubling me as interim Chair of the Hancock Democrats—and it sounds like it troubles him as well as Chair of the Hancock Republicans.
For the People: Fact Checking
Chatting with our Doctor during our annual checkups he observed that listening to “a lot of talk radio” he heard that immigrants were getting “$2000 per month and free housing” an assertion that shocked us and we immediately said, “can’t be true.” How fascinating that such stories proliferate in our world, unverified and passed along as truth. As retired academics, a librarian and an English Prof, we had to investigate. We discovered the idea comes from TV: “It relies on an Aug.
Tim Walz: Was man über Harris' Vize wissen muss
Harris' Vize im Porträt:Was man über Tim Walz wissen muss 06.08.2024 | 17:17 Die demokratische Präsidentschaftskandidatin Kamala Harris hat ihren möglichen Vize benannt: Es ist der 60-jährige Tim Walz, ein Mann des Mittleren Westens. Kamala Harris will mit Tim Walz in den US-Wahlkampf ziehen.
For the People: Church/State
The Bay St. Louis Little Theatre production of Robert Bolt’s “A Man for All Seasons” triggered in me a surprising recognition of the origins of Church/State dichotomy.
A review of Bay St. Louis Little Theatre's "A Man for all Seasons"
If anyone ever wondered why The Bay St. Louis Little Theatre was uniquely given the Mississippi Governor’s Award for Excellence, the current production of Robert Bolt’s A Man for All Seasons gives full evidence. The production of a play as challenging as Shakespeare is done by a company of fourteen actors who “transport us completely to another time,” as one audience member said in front of me upon leaving the theatre.
The binding and mechanism of a positive allosteric modulator of Kv3 channels - Nature Communications
Abstract Small-molecule modulators of diverse voltage-gated K+ (Kv) channels may help treat a wide range of neurological disorders. However, developing effective modulators requires understanding of their mechanism of action. We apply an orthogonal approach to elucidate the mechanism of action of an imidazolidinedione derivative (AUT5), a highly selective positive allosteric modulator of Kv3.1 and Kv3.2 channels.
For the People
Coverage of Martin Luther King Day in The Sea Coast Echo reflected how much influence his life had on American Society as the leader of the Civil Rights Movement. Pastor Richardson’s “Devotional Page” recounted Dr. King’s life and import as did the ceremonies at St. Rose of Lima he mentions.
For The People: Voting & Democracy
I spent seven hours Tuesday, August 8, working “For the People” and thinking about the whole enterprise. At my age, working from 2:30 to 10:30 is much longer than a full day. But someone has to do it. I was part of a “Resolution Board” of two Democrats and three Republicans who were there to decide on any questionable ballots cast in the Primary Election.
The impact of economic developments on life sciences: a TP perspective
Although the arm's length principle is based on a direct comparison with market prices, in practice the arm's length nature of intercompany transactions is often assessed indirectly by considering the resulting profitability. In times like these, with high inflation, supply chain disruptions, profound changes in public spending and many other external drivers, economic developments affect the profitability of legal entities within a multinational company in various ways .
The solute carrier SPNS2 recruits PI(4,5)P2 to synergistically regulate transport of sphingosine-1-phosphate
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WARNING TO GRANDPARENTS
Dear Echo, As I was waving my Johnny Dupree sign outside the Waveland Library Voting Place, an older gentleman (younger than I though), came over to ask me why he should vote for Dupree. I answered, well, he was elected three times Mayor of Hattiesburg, but he replied, “That’s why I don’t like him. I don’t trust any politicians.” That cynicism you hear all the time—it is a commonplace. And so wrong. Why do you want a non-politician to do a political job?
Using machine learning to predict quantitative phenotypes from protein and nucleic acid sequences
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The curious case of parallel imports in life sciences
The diversity of intellectual property (IP) protection and healthcare cost management practices across major jurisdictions gives rise to the curious case of parallel imports of prescription drugs. This article explains the transfer pricing implications of parallel imports in the life sciences industry and analyses a landmark court case involving parallel imports.
America must prepare for war with China over Taiwan
China’s massive investment in the People’s Liberation Army (PLA) may show China is preparing to fundamentally change the status quo and preparing for possible war with the United States over Taiwan. To deter China, the United States must rapidly build up its forces in the Pacific, continue to strengthen military alliances in the region to ensure access to bases in time of conflict, and accelerate deliveries of purchased military equipment to Taiwan.
The US cannot allow China to think it will abandon Taiwan
Speaking at Singapore’s International Institute for Strategic Studies, Secretary of Defense Lloyd AustinLloyd AustinThe US cannot allow China to think it will abandon Taiwan Overnight Defense: First group of Afghan evacuees arrives in Virginia | Biden signs Capitol security funding bill, reimbursing Guard | Pentagon raises health protection level weeks after lowering it China moves quickly to replace America in Afghanistan MORE recently outlined U.S. interests and commitments in the...
Structure and inhibition mechanism of the human citrate transporter NaCT
Abstract Citrate is best known as an intermediate in the tricarboxylic acid cycle of the cell. In addition to this essential role in energy metabolism, the tricarboxylate anion also acts as both a precursor and a regulator of fatty acid synthesis1,2,3. Thus, the rate of fatty acid synthesis correlates directly with the cytosolic concentration of citrate4,5.
OPINION EXCHANGE | Remember the price we paid in the Pacific
The strategic confrontation between the United States and China evokes memories of an earlier conflict between America and Japan — a conflict that began 79 years ago today and changed the lives of Americans from every corner of the country — and has rekindled understanding of the strategic importance of the Pacific region for the United States. The war against Japan flung the sons and daughters of small-town America across the vast reaches of the western ocean.
The next US president has a tall order: Keeping China in check
No matter who wins the election, the next U.S. president will face an increasingly complex international security environment, highlighted by a powerful China, a revisionist Russia, and a nuclear-armed North Korea (and possibly Iran), as well as transnational threats such as terrorism, narcotics trafficking and cyber hacking and influence operations. These challenges will be compounded by the persistent COVID-19 pandemic and its continued negative impact on the world economy.
"Game Show Battle Rooms" opening in Overland Park!
This post was contributed by a community member. The views expressed here are the author's own. Thu, Sep 17, 2020 at 3:30 PM 10520 Metcalf Lane, Overland Park, KS, 66212 More info: https://www.gameshowbattlerooms.com/kansascity Hi Neighbors! We are a new business opening up in Overland Park and wanted to introduce ourselves to you! We are "Game Show Battle Rooms".
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