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Articles by de Man
Astrophysics > Instrumentation and Methods for Astrophysics
[Submitted on 22 Oct 2026] Title:Simulation-based inference of profile evolution for high-precision pulsar timing View a PDF of the paper titled Simulation-based inference of profile evolution for high-precision pulsar timing, by Sai C. Susarla and 4 other authors View PDF HTML (experimental) Abstract:Pulsars are exceptional cosmic laboratories, the most stable of which rival atomic clocks.
Prevention norms across socio-ecological levels and their relationship to PrEP-intention among men who have sex with men: a structural equation model
Background Social norms around PrEP act as both barriers to and stimulants of the use of PrEP across a wide range of target populations, yet remain relatively understudied. To stimulate theoretical innovation and provide a quantitative check for qualitative findings, we integrate norm types from the Behavioral Models (BM) and the Social Norms Approach (SNA) into the socio-ecological model (SEM) and analyze their relationship with PrEP-intention.
Exploring the Impact of Delivering Allergy Medication as Self-Care on Healthcare Greenhouse Gas Emissions in the United Kingdom
Scope This study focused on the potential environmental value of patient self-care in the UK by evaluating the potential impact on GHG emissions of the substitution of all self-treatable healthcare visits by over-the-counter (OTC) and self-care medication. Ethics approval was not required for this study, which did not involve any animals or human participants.
Translational 3D in vitro models for immunotherapy testing: from reconstituted organoid co-culture assays to autologous ex vivo patient tissues
Abstract The lack of patient-relevant, clinically predictive models for early (immuno)-oncology (IO) drug discovery is a significant challenge for drug developers. Advances in three-dimensional (3D) cell culture technologies are narrowing the gap for preclinical drug testing, capturing cell–cell and cell–matrix interactions, extracellular matrix components, and spatial organization absent in 2D systems and crucial in modeling immunotherapy efficacy.
Coronary pathophysiology in idiopathic pulmonary arterial hypertension: A systems medicine study
Boland, E. et al. (2026) Coronary pathophysiology in idiopathic pulmonary arterial hypertension: A systems medicine study. Journal of Clinical Investigation, (PMID:41569941) (Accepted for Publication) Text 380304.pdf - Accepted Version Restricted to Repository staff only 1MB Articles Cardiology, cardiovascular disease, hypertension, microcirculation, pulmonology, vascular biology.
UFO Trees: Practical and Provably-Efficient Parallel Batch-Dynamic Trees
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
[2509.14433] Fast and Compact Sketch-Based Dynamic Connectivity
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
Hessequa Harmonie Vier Borgvennote Met N Elegante Aand By De Hoek Manor
Home Mixed News Hessequa Harmonie Vier Borgvennote Met 'n Elegante Aand By De Hoek Man HESSEQUA NUUS - Die Hessequa Harmonie-musiek- en kunsfees het sy borge onlangs in styl gevier met n elegante aand by De Hoek Manor in Stellenbosch. Gaste is verwelkom deur Andre van Vuuren Disclaimer: We are a news aggregator. See full disclaimer here.
Discovering novel germline genetic variants linked to severe fluoropyrimidine-related toxicity in- and outside DPYD - Genome Medicine
While applying prospective DPYD genotyping to clinical practice has successfully reduced the incidence of severe toxicity, a substantial number of patients treated with fluoropyrimidines still experience severe treatment-related toxicity [5]. We hypothesized that in addition to the four established DPYD variants, other genetic variations in- and outside DPYD might be associated with the onset of severe fluoropyrimidine-related toxicity.
Tricuspid regurgitation in pulmonary arterial hypertension: a right ventricular volumetric and functional analysis
Footnotes Conflict of interest: H.J. Bogaard received research grants and lecture fees from Janssen Pharmaceuticals and MSD, and serves on an advisory board for Novartis. The remaining authors have no potential conflicts of interest to disclose. This article has an editorial commentary: https://doi.org/10.1183/13993003.00797-2024 Support statement: H.J. Bogaard, A.
A Fatal Outcome after Cessation of Nucleotide Analogue Therapy in a Patient with Chronic Hepatitis B: A Case Report
Keywords: Hepatitis B, Liver transplantation, Nucleos(t)ide analogues cessation, Case report Worldwide, 296 million individuals are chronically infected by the hepatitis B virus (HBV) [1]. Chronic hepatitis B (CHB) is associated with significant comorbidity and mortality as those patients are at risk to develop liver cirrhosis and hepatocellular carcinoma [1]. Viral eradication is the ultimate goal to halt further progression of liver-related complications.
Long-term outcomes of ruptured hepatocellular carcinoma: international multicentre study
Hepatocellular carcinoma (HCC) is one of the deadliest malignancies, with a cancer-related mortality ranking third after those for lung and colorectal cancer1,2. Spontaneous HCC rupture may occur in 5–10%3. Ruptured HCC can lead to haemorrhage and thereby result in high short-term mortality rates (30–70%)4–6. Although risk factors for rupture have been identified7, the underlying pathophysiology of ruptured HCC remains unknown.
Vitamin C deficiency can lead to pulmonary hypertension: a systematic review of case reports - BMC Pulmonary Medicine
We identified 32 case reports which suggested that vitamin C deficiency was the cause of PH [76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100,101,102,103,104,105] (Supplements 1 and 2). The oldest reports were published in 1996 [92] and 2003 [99], while 21 have been published since 2019 (Table 1). Over half were from the USA and the remaining cases originated from several other countries.
Embedding routine health care data in clinical trials: with great power comes great responsibility - Netherlands Heart Journal
Abstract Randomised clinical trials (RCTs) are vital for medical progress. Unfortunately, ‘traditional’ RCTs are expensive and inherently slow. Moreover, their generalisability has been questioned. There is considerable overlap in routine health care data (RHCD) and trial-specific data. Therefore, integration of RHCD in an RCT has great potential, as it would reduce the effort and costs required to collect data, thereby overcoming some of the major downsides of a traditional RCT.
Effects of empagliflozin on right ventricular adaptation to pressure overload
Julie S. Axelsen1, 2* Anders H.
Vitamin C may reduce troponin and CKMB levels after PCI and CABG: a meta-analysis
BMC Cardiovascular Disorders, Sep 2023 Ischemia/reperfusion injury contributes to periprocedural myocardial injury (PMI) in patients undergoing percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG). PMI can be estimated by the elevation of troponin (Tn) and creatine kinase-MB (CKMB) plasma levels, and it is associated with increased risk of cardiovascular events and mortality.
Sex-biased TGFβ signaling in pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is a rare cardiovascular disorder leading to pulmonary hypertension and, often fatal, right heart failure. Sex-differences in PAH are evident, which primarily presents with a female predominance and increased male severity.
Pathophysiology of the right ventricle in health and disease: an update
The contribution of the right ventricle (RV) to cardiac output is negligible in normal resting conditions when pressures in the pulmonary circulation are low. However, the RV becomes relevant in healthy subjects during exercise, and definitely so in patients with increased pulmonary artery pressures both at rest and during exercise. The adaptation of RV function to loading rests basically on an increased contractility.
Hepatitis E virus infection remodels the mature tRNAome in macrophages to orchestrate NLRP3 inflammasome response | Proceedings of the National Academy of Sciences
Skip to main content Hepatitis E virus infection remodels the mature tRNAome in macrophages to orchestrate NLRP3 inflammasome response Yunlong Li https://orcid.org/0000-0002-0115-9342, Ruyi Zhang, Yining Wang, +6 , Pengfei Li, Yang Li, Harry L. A. Janssen, Robert A. de Man https://orcid.org/0000-0002-1932-7412, Maikel P.
Mucin-microbiome signatures shape the tumor microenvironment in gastric cancer
Microbiome, Apr 2023 This is a preview of a remote PDF: https://microbiomejournal.biomedcentral.com/counter/pdf/10.1186/s40168-023-01534-w Oosterlinck, Baptiste, Ceuleers, Hannah, Arras, Wout, De Man, Joris G., Geboes, Karen, De Schepper, Heiko, Peeters, Marc, Lebeer, Sarah, Skieceviciene, Jurgita, Hold, Georgina L., Kupcinskas, Juozas, Link, Alexander, De Winter, Benedicte Y., Smet, Annemieke. , Microbiome, 2023, pp. 1-18, Volume 11, Issue 1, DOI: 10.1186/s40168-023-01534-w
Tangential Heritage Values in Museum Communication
1. Introduction The process of packaging heritage as an experience for the museum-goer has a quite long tradition and, for the most part, uses simplifications complementary to a specific exhibition. It builds on umbrella preconceptions that appeal to the widest sociocultural audience possible, as it needs to function as a consensual, universal enhancer.
Induction of broad multifunctional CD8+ and CD4+ T cells by hepatitis B virus antigen-based synthetic long peptides ex vivo
Introduction Chronic infection with the Hepatitis B virus (HBV) is a major global health burden that currently affects approximately 240 million people worldwide (1). Treatment with nucleos(t)ide analogs (NAs) can suppress viral replication but offers neither cure nor full abolition of the chronic HBV infection (cHBV)-related risk for hepatocellular carcinoma (HCC) or liver cirrhosis. Importantly, NAs need to be taken for life (2).
Optimization of PET protocol and interrater reliability of 18F-PSMA-11 imaging of prostate cancer - EJNMMI Research
Materials and methods All procedures performed in this study involving human participants were in accordance with the ethical standards of the Ethics Committee of the Ghent University Hospital (2017/1294) and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards (EudraCT nr, 2017-003461-96). The study was supported by the Flemish Foundation FWO TBM (T001517).
Semantic Music Production: A Meta-Study
Semantic Music Production: A Meta-Study × Cite This Citation & Abstract D. Moffat, B. De Man, and JO. D.. Reiss, "Semantic Music Production: A Meta-Study," J. Audio Eng. Soc., vol. 70, no. 7/8, pp. 548-564, (2022 July.). doi: D. Moffat, B. De Man, and JO. D.. Reiss, "Semantic Music Production: A Meta-Study," J. Audio Eng. Soc., vol. 70 Issue 7/8 pp. 548-564, (2022 July.).
TOWARDS THE LAST STAGES OF THE CERN’S AD-TARGET AREA CONSOLIDATION PROJECT AND RECOMMISSIONING PLANS TO RESUME OPERATION
Home > Towards the Last Stages of the CERN’s AD-Target Area Consolidation Project and Recommissioning Plans to Resume Operation Title Towards the Last Stages of the CERN’s AD-Target Area Consolidation Project and Recommissioning Plans to Resume Operation Related title TOWARDS THE LAST STAGES OF THE CERN’S AD-TARGET AREA CONSOLIDATION PROJECT AND RECOMMISSIONING PLANS TO RESUME OPERATION Author(s) Torregrosa, Claudio (CERN) ; Ahdida, Claudia (CERN) ; Bouvard, Aymeric (CERN) ; Broche, Alexandre...
A turquoise fluorescence lifetime-based biosensor for quantitative imaging of intracellular calcium - Nature Communications
Abstract The most successful genetically encoded calcium indicators (GECIs) employ an intensity or ratiometric readout. Despite a large calcium-dependent change in fluorescence intensity, the quantification of calcium concentrations with GECIs is problematic, which is further complicated by the sensitivity of all GECIs to changes in the pH in the biological range.
Equilibrating SSC guidelines with individualized care - Critical Care
References Vincent JL, Marshall JC. Surviving sepsis: a guide to the guidelines. Crit Care. 2008;12:162. Article Google Scholar Evans L, Rhodes A, Alhazzani W, Antonelli M, Coopersmith CM, French C et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Intensive Care Med. 2021;47:1181–1247. Santacruz CA, Pereira AJ, Celis E, Vincent JL. Which multicenter randomized controlled trials in critical care medicine have shown reduced mortality?
Density of Patient-Sharing Networks: Impact on the Value of Parkinson Care
Document Type : Original Article Authors Floris P. Vlaanderen 1 Yvonne de Man 1 Marit A.C. Tanke 1 Marten Munneke 1, 2, 3, 4 Femke Atsma 1 Marjan J. Meinders 1 Patrick P.T. Jeurissen 1 Bastiaan R. Bloem 1, 2, 3, 4 Jesse H.
Vitamin C and COVID-19
Introduction About 100 animal studies have shown that vitamin C can prevent and alleviate many kinds of viral and bacterial infections (1, 2). Because of the great diversity in the infectious agents in those studies, it is evident that the effect of vitamin C is not restricted to any specific virus or bacterium.
Immunosuppressive drug withdrawal late after liver... : European Journal of Gastroenterology & Hepatology
Introduction Liver transplantation (LTx) is the only treatment for end-stage liver disease. To prevent allograft rejection after transplantation, the use of immunosuppressive drugs (IS) is indispensable. However, in a significant proportion of LTx recipients, long-term use of IS leads to severe side effects such as (persistent) infections, metabolic disorders (e.g. diabetes, dyslipidemia), renal dysfunction, cardiovascular disease, and malignancies [1–6].
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