Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Articles by Derek Klarin
Exome-wide association study of blood lipids in 1,158,017 individuals from diverse populations
Abstract Rare coding alleles have crucial roles in the molecular diagnosis of genetic diseases. However, the systematic identification of these alleles has been challenging due to their scarcity in the general population. Here we discovered and characterized rare coding alleles contributing to genetic dyslipidemia, a principal risk for coronary artery disease (CAD), among 1,158,017 multi-ancestral individuals.
Dissecting the Genetic Architecture of Intracranial Aneurysms
Get full access to this article View all available purchase options and get full access to this article. Supplemental Material File (circcvg-2024-004626-t-s01.pdf) Supplemental Methods Tables S1–S11 Figures S1–S12 References 38–56 File (circcvg-2024-004626-t-s02.xlsx) References 1. Hop JW, Rinkel GJE, Algra A, van Gijn J. Case-Fatality rates and functional outcome after subarachnoid hemorrhage: a systematic review. Stroke. 1997;28:660–664. doi: 10.1161/01.str.28.3.660 2. Brown RD, Broderick JP.
Practical Guide to Multiomics Big Data Sources
Guide to Statistics and Methods Practical Guide to Multiomics Big Data Sources Guide to Statistics and Methods Practical Guide to the Use of AI-Enabled Analytics in Research Anai N. Kothari, MD; Amy H. Kaji, MD; Genevieve B. Melton, MD Guide to Statistics and Methods Practical Guide to AI, Chatbots, and Large Language Models in Research Tyler J. Loftus, MD, PhD; Adil Haider, MD, MPH; Gilbert R.
Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target - Nature Genetics
|
Abstract Abdominal aortic aneurysm (AAA) is a common disease with substantial heritability. In this study, we performed a genome-wide association meta-analysis from 14 discovery cohorts and uncovered 141 independent associations, including 97 previously unreported loci. A polygenic risk score derived from meta-analysis explained AAA risk beyond clinical risk factors.
By Tanmoy Roychowdhury, Derek Klarin, Michael Levin, Joshua M. Spin, Colwyn A. Headley, Noah Tsao, Corry Gellatly, Verena Zuber, Shefali S. Verma, Adam E. Locke, Gudmundur Einarsson, Gudmar Thorleifsson, Sarah Graham, Ozan Dikilitas, Brooke Wolford, Ben M Brumpton, Laura Calsina Juscafresa, Dadong Li, Karina Banasik, Søren Brunak, Lasse M. Obel, Ewa Strauss, Mercedes Camacho, Peter K Henke, Santhi K. Ganesh, James S Pankow, Nathan Pankratz, Ole B. Pedersen, Christian Erikstrup, Daniel F. Gudbjartsson, Solveig Gretarsdottir, Hilma Holm, Kari Stefansson, Manuel A Ferreira, Aris Baras, Iftikhar J. Kullo, Marylyn D. Ritchie, Sisse R. Ostrowski, Stephen Burgess, Dipender Gill, Maria Sabater-Lleal, Gregory T. Jones, Matthew Bown, Philip S. Tsao, Cristen J. Willer, Ina Holst Laursen, Jaume Dilmé, Olga Peypoch, Rikke L. Jacobsen, Katie L. Saxby
|
Nature
Verified
Genome-wide association study of thoracic aortic aneurysm and dissection in the Million Veteran Program - Nature Genetics
|
Abstract The current understanding of the genetic determinants of thoracic aortic aneurysms and dissections (TAAD) has largely been informed through studies of rare, Mendelian forms of disease.
By Derek Klarin, Anoop K. Sendamarai, Sarah Graham, Michael Levin, James P Pirruccello, Yanming Li, Minxian Wang, Krishna G. Aragam, Kaavya Paruchuri, Verena Zuber, Noah Tsao, Shefali S. Verma, Daniel Rader, Ron Do, Girish N. Nadkarni, Marylyn D. Ritchie, Stephen Burgess, Dong-chuan Guo, Patrick T. Ellinor, Scott Lemaire, Dianna Milewicz, Cristen J. Willer, Pradeep Natarajan, Philip S. Tsao, Saiju Pyarajan
|
Nature
Verified
Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism - Nature Communications
|
The research in this study complies with all relevant ethical regulations.
By Mun-Gwan Hong, Philip Dusart, David Kotol, Fredrik Edfors, Mine Koprulu, Maik Pietzner, Claudia Langenberg, Scott M. Damrauer, Andrew Johnson, Derek Klarin, Angela Silveira, Mathias Uhlén, Angel Martinez-Perez, Jean-Francois Deleuze, Alice Assinger, Jochen Schwenk, Lynn Butler, Clément Naudin, Gaëlle Munsch, Louisa Goumidi, Waltraud Schottmaier, Pierre-Emmanuel Morange, David-Alexandre Trégouët
|
Nature
Verified
Large-scale genome-wide association study of coronary artery disease in genetically diverse populations - Nature Medicine
|
Abstract We report a genome-wide association study (GWAS) of coronary artery disease (CAD) incorporating nearly a quarter of a million cases, in which existing studies are integrated with data from cohorts of white, Black and Hispanic individuals from the Million Veteran Program.
By Catherine Tcheandjieu, Xiang Zhu, Shoa L. Clarke, Valerio Napolioni, Marijana Vujkovic, Derek Klarin, Michael Levin, Nasa Sinnott-Armstrong, Genevieve L Wojcik, Alexander Bick, Jie Huang, Yuk-Lam Ho, Steven Buyske, Charles Kooperberg, Ron Do, Kumardeep Chaudhary, Kari E. North, Christy L. Avery, Joshua C. Bis, Ozan Dikilitas, Iftikhar J. Kullo, Ian B. Stanaway, Bahram Namjou, Kazuyoshi Ishigaki, Marylyn D. Ritchie, Rachel L. Kember, Aris Baras, Donald Miller, Peter D. Reaven, Pradeep Natarajan, Jennifer Huffman Verified, Benjamin F Voight, Daniel Rader, Kyong-Mi Chang, Julie Lynch, Scott M. Damrauer, Hua Tang, Yan Sun, Philip S. Tsao, Themistocles L. Assimes, Austin T. Hilliard, Bryan R. Gorman, Shefali S. Verma, Biobank Japan
|
Nature
Verified
A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation | Nature Genetics
|
Abstract Nonalcoholic fatty liver disease (NAFLD) is a growing cause of chronic liver disease. Using a proxy NAFLD definition of chronic elevation of alanine aminotransferase (cALT) levels without other liver diseases, we performed a multiancestry genome-wide association study (GWAS) in the Million Veteran Program (MVP) including 90,408 cALT cases and 128,187 controls.
By Marijana Vujkovic, Kim Lorenz, Xiuqing Guo, Heather J. Cordell, Joseph Park, Kyung Min Lee, David Kaplan, Xiang Zhu, Catherine Tcheandjieu, Rachel L. Kember, Henry R Kranzler, Ayush Giri, Derek Klarin, Yan Sun, Jie Huang, Jennifer Huffman Verified, Kate Townsend Creasy, Nicholas Hand, Ching-Ti Liu, Matthew J. Budoff, Henry Lin, Silvia Vilarinho Verified, Adam E. Locke, Aris Baras, Brent A Neuschwander-Tetri, Kathleen Ryan, Dipender Gill, Elisabetta Manduchi, Donald Miller, Peter D. Reaven, Lawrence Phillips, Scott Duvall, Themistocles L. Assimes, Todd L. Edwards, Scott M. Damrauer, Amit V. Khera, Philip S. Tsao, Danish Saleheen, Julie Lynch, Daniel Rader, Kyong-Mi Chang, Walter R. Witschey, Geisinger-regeneron DiscovEhr Collaboration
|
Nature
Verified
High heritability of ascending aortic diameter and trans-ancestry prediction of thoracic aortic disease - Nature Genetics
Abstract Enlargement of the aorta is an important risk factor for aortic aneurysm and dissection, a leading cause of morbidity in the developed world. Here we performed automated extraction of ascending aortic diameter from cardiac magnetic resonance images of 36,021 individuals from the UK Biobank, followed by genome-wide association.
Cross-Ancestry Investigation of Venous Thromboembolism Genomic Predictors
Originally publishedhttps://doi.org/10.1161/CIRCULATIONAHA.122.059675Circulation. 2022;146:1225–1242 Abstract Background: Venous thromboembolism (VTE) is a life-threatening vascular event with environmental and genetic determinants. Recent VTE genome-wide association studies (GWAS) meta-analyses involved nearly 30 000 VTE cases and identified up to 40 genetic loci associated with VTE risk, including loci not previously suspected to play a role in hemostasis.
Endothelial lipase mediates efficient lipolysis of triglyceride-rich lipoproteins
Loading metrics Open Access Peer-reviewed Research Article Sumeet A. Khetarpal , Cecilia Vitali , Michael G. Levin, Derek Klarin, Joseph Park, Akhil Pampana, John S. Millar, Takashi Kuwano, Dhavamani Sugasini, Papasani V. Subbaiah, Jeffrey T. Billheimer, Pradeep Natarajan, Daniel J. Rader Sumeet A. Khetarpal, Cecilia Vitali, Michael G. Levin, Derek Klarin, Joseph Park, Akhil Pampana, John S. Millar, Takashi Kuwano, Dhavamani Sugasini, Papasani V.
Genetic Architecture of Abdominal Aortic Aneurysm in the Million Veteran Program
Clinical Perspective What Is New? A genome-wide association study of abdominal aortic aneurysm (AAA) further defines the role of common genetic variation in disease susceptibility. Mendelian randomization analysis supports a causal role for smoking liability and diastolic blood pressure in the pathogenesis of AAA. A polygenic risk score based on 29 genome-wide AAA risk variants strongly associates with AAA independent of family history and 6 additional clinical risk factors.
The relationship between circulating lipids and breast cancer risk: A Mendelian randomization study
Loading metrics Open Access Peer-reviewed Research Article Kelsey E. Johnson , Katherine M. Siewert , Derek Klarin, Scott M. Damrauer, the VA Million Veteran Program , Kyong-Mi Chang, Philip S. Tsao, Themistocles L. Assimes, Kara N. Maxwell, Benjamin F. Voight Kelsey E. Johnson, Katherine M. Siewert, Derek Klarin, Scott M. Damrauer, the VA Million Veteran Program, Kyong-Mi Chang, Philip S. Tsao, Themistocles L. Assimes, Kara N. Maxwell, Benjamin F.
Long-Term Cardiovascular Risk in Women With Hypertension During Pregnancy
Journal of the American College of Cardiology Original Investigation Michael C. Honigberg, Seyedeh Maryam Zekavat, Krishna Aragam, Derek Klarin, Deepak L. Bhatt, Nandita S. Scott, Gina M. Peloso and Pradeep Natarajan This article requires a subscription or purchase to view the full text. If you are a subscriber or member, click the login link or the subscribe link in the top menu above to access this article. Author + information vol. 74 no.
Long-Term Cardiovascular Risk in Women With Hypertension During Pregnancy
Journal of the American College of Cardiology Original Investigation Michael C. Honigberg, Seyedeh Maryam Zekavat, Krishna Aragam, Derek Klarin, Deepak L. Bhatt, Nandita S. Scott, Gina M. Peloso and Pradeep Natarajan This article requires a subscription or purchase to view the full text. If you are a subscriber or member, click the login link or the subscribe link in the top menu above to access this article. Author + information Michael C.
Genome-wide association analysis of venous thromboembolism identifies new risk loci and genetic overlap with arterial vascular disease
Abstract Venous thromboembolism is a significant cause of mortality1, yet its genetic determinants are incompletely defined.
Genome-wide association study of peripheral artery disease in the Million Veteran Program
Abstract Peripheral artery disease (PAD) is a leading cause of cardiovascular morbidity and mortality; however, the extent to which genetic factors increase risk for PAD is largely unknown. Using electronic health record data, we performed a genome-wide association study in the Million Veteran Program testing ~32 million DNA sequence variants with PAD (31,307 cases and 211,753 controls) across veterans of European, African and Hispanic ancestry.
Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program
1.Collins, R. What makes UK Biobank special? Lancet 379, 1173–1174 (2012).2.Gaziano, J. M. et al. Million Veteran Program: a mega-biobank to study genetic influences on health and disease. J. Clin. Epidemiol. 70, 214–223 (2016).3.The Emerging Risk Factors Collaboration. Major lipids, apolipoproteins, and risk of vascular disease. J. Am. Med. Assoc. 302, 1993–2000 (2009).4.Teslovich, T. M. et al. Biological, clinical and population relevance of 95 loci for blood lipids.
Risk factor profile and anatomic features of previously asymptomatic patients presenting with carotid-related stroke
Publication HistoryPublished online: May 24, 2018Accepted: January 31, 2018; Received: November 9, 2017;
Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease
In 405,569 individuals in UK Biobank (335,660 individuals of European ancestry and 69,909 individuals of Non-European ancestry, Supplementary Table 1), we analyzed the association of 3759 pLOF variants with six metabolic traits [body mass index (BMI), waist-to-hip ratio adjusted for body mass index (WHRadjBMI), height, systolic blood pressure (SBP), diastolic blood pressure (DBP), forced expiratory volume to forced vital capacity ratio (FEV1/FVC)], six cardiometabolic diseases (coronary...
Genetic Variation at the Sulfonylurea Receptor, Type 2 Diabetes, and Coronary Heart Disease
Genetic Variation at the Sulfonylurea Receptor, Type 2 Diabetes, and Coronary Heart Disease Connor A. Emdin, Derek Klarin, Pradeep Natarajan, CARDIOGRAM Exome Consortium, Jose C. Florez, Sekar Kathiresan, Amit V. Khera Diabetes Aug 2017, 66 (8) 2310-2315; DOI: 10.2337/db17-0149
Show More
loading
Actions
Is this you?
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Get in touch with Derek
Contact Derek, search articles and posts on X, monitor coverage, and track replies from one place.
Learn more about Muck Rack