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Articles by Derek Tan
Warehouse Automation Strategy: Process Redesign Over Technology
A retailer invests millions in a highly automated distribution center. The picking engine is efficient; the robots work without any glitches, and yet within weeks of go-live, a bottleneck has formed. Not inside the automation, but on either side of it. The inbound decant process and the post-pick packing area weren't redesigned to match the speed of the new system. The business optimized one node to create pressure points in others. The operation doesn't begin or end at the pick module.
Commentary: The invisible workforce helping Singapore age well
SINGAPORE: When we think about healthcare, hospitals typically come to mind - doctors, nurses and other medical professionals who diagnose illness, provide treatment, and help patients recover. Less visible are the many people working to support seniors in their daily lives. Community therapists at Senior Care Centres help seniors rebuild strength and confidence after a fall. Programme executives at Active Ageing Centres coordinate activities to keep seniors socially engaged.
S5 Ep19: Meat Business Women organisation fills an important role
IN today’s podcast episode, host Kerry Lonergan sits down with three women turning the tables in an historically male-dominated meat industry. The Meat Business Women networking and personal development organisation held its annual conference in Brisbane recently, attracting a rowdy crowd of 250. The organisation aims to empower women to make their mark in the meat industry.
Chalkophore-mediated respiratory oxidase flexibility controls M. tuberculosis virulence
eLife Assessment In this important study, the authors advance our understanding of copper uptake by chalkophores and their targeted metalloproteins in Mycobacterium tuberculosis. These convincing data demonstrate that chalkophore-acquired copper is solely incorporated into the Mtb bcc:aa3 copper-iron respiratory oxidase under low copper conditions, and that chalkophore-mediated protection of the respiratory chain is critical to Mtb virulence.
Chalkophore mediated respiratory oxidase flexibility controls M. tuberculosis virulence
Abstract Oxidative phosphorylation has emerged as a critical therapeutic vulnerability of M. tuberculosis (Mtb). However, it is unknown how intracellular bacterial pathogens such as Mtb maintain respiration during infection despite the chemical effectors of host immunity. Mtb synthesizes diisonitrile lipopeptides that tightly chelate copper, but the role of these chalkophores in host-pathogen interactions is also unknown. We demonstrate that M.
The Golden Age of Private Credit
Derek Tan · Follow 2 min read · -- One of the hottest topics in mainstream finance media today is the meteoric rise of private credit, from an obscure financing tool leveraged by middle market companies to a universal capital solutions engine that powers even the largest corporations today.
S4 Ep38: Sustainability credentials, with Catherine Marriott
In this week’s episode of the Weekly Grill podcast, host Kerry Lonergan sits down with respected leader for change and 2024 Nuffield Scholar, Catherine Marriott who presented at the BeefEx feedlot convention in Brisbane recently. Over the last 20 years, Catherine has worked as an executive, a non-executive director and consulting roles in the agricultural, research and regional development sectors in Australia and internationally.
50 bps in one go - what is happening to the Fed?
Derek Tan · Follow 9 min read · -- Federal Reserve Chair Jerome Powell (Source: PBS) Welcome to the Commentary Corner by Derek Tan. This is a new (experimental) series where I attempt to deconstruct interesting things happening in the financial markets in a simple and easy-to-understand manner. What’s the motivation behind this, you may ask? Well, a long time ago, well before my time in finance, I used to work in tech.
Structural basis for transthiolation intermediates in the ubiquitin pathway - Nature
Abstract Transthiolation (also known as transthioesterification) reactions are used in the biosynthesis of acetyl coenzyme A, fatty acids and polyketides, and for post-translational modification by ubiquitin (Ub) and ubiquitin-like (Ubl) proteins1,2,3. For the Ub pathway, E1 enzymes catalyse transthiolation from an E1~Ub thioester to an E2~Ub thioester.
Chalkophore mediated respiratory oxidase flexibility controls M. tuberculosis virulence
Abstract Oxidative phosphorylation has emerged as a critical therapeutic vulnerability of M. tuberculosis, but it is unknown how M. tuberculosis and other pathogens maintain respiration during infection. M. tuberculosis synthesizes diisonitrile lipopeptide chalkophores that chelate copper tightly, but their role in host-pathogen interactions is also unknown. We demonstrate that M. tuberculosis chalkophores maintain the function of the heme-copper bcc:aa3 respiratory oxidase under copper limitation.
Winds of change for S-Reits as interest rates normalise
Derek Tan Published Mon, Mar 11, 2024 · 6:11 pm A Singapore data centre in Keppel DC Reit's portfolio. Investors should consider investing in line with structural, secular trends of suburban retail, logistics and data centres. PHOTO: BT FILE Enjoy reading! Enjoy your subscriber-only story! START READING You have received a gift! Unlock this subscriber-only story by signing up or log in to start reading.
Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase - Nature Communications
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Abstract Malaria poses an enormous threat to human health. With ever increasing resistance to currently deployed drugs, breakthrough compounds with novel mechanisms of action are urgently needed. Here, we explore pyrimidine-based sulfonamides as a new low molecular weight inhibitor class with drug-like physical parameters and a synthetically accessible scaffold.
By Stanley C. Xie, Yinuo Wang, Craig Morton, Riley D. Metcalfe, Elyse Dunn, Eva S. Istvan, Joon Sung Park, Tomas Yeo, Mathamsanqa N. Bhebhe, Peter Rutledge, Luiz C Godoy, Sumanta Dey, Yawei Du, Nicholas Williamson, Patrick Thomson, Derek Tan, Jacquin C. Niles, Daniel Goldberg, Jeremy Burrows, David A Fidock, Matthew Todd, Nutpakal Ketprasit, Tanya Puhalovich, Gerry Shami
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Nature
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Direct conversion of amino acids to oxetanol bioisosteres via photoredox catalysis
Direct conversion of amino acids to oxetanol bioisosteres via photoredox catalysis† Carboxylic acids are an important structural feature in many drugs, but are associated with a number of unfavorable pharmacological properties. To address this problem, carboxylic acids can be replaced with bioisosteric mimics that interact similarly with biological targets but avoid these liabilities.
Episode 9: Rural property values with Tim Lane and Rawdon Briggs
What’s driving the property market amid an unprecendented period of super heated cattle prices, super low interest and largely improved seasonal conditions? In this Beef 2021 special episode of The Weekly Grill from Rockhampton, brought to you by Colliers Agribusiness, host Kerry Lonergan talks to Herron Todd White’s Tim Lane and Colliers International’s Rawdon Briggs look at where the market is heading. Click above to listen to the podcast.
What is the Next Step for OTT Platforms and How Will They Evolve in the Future?
The arrival of the internet has no doubt fundamentally changed the way we interact and consume our video content. Long gone is the era where we adhered to the programming schedules of TV or cable channels. We now have the uncanny ability to grab whatever, wherever, and whenever we want. This media service known as Over-The-Top, or OTT, bypasses much of the traditional providers.
Build a Cross-Region Hybrid Cloud Storage Gateway for AI at WeRide
Save {{ articles[0].views | formatCount}} Views Join the DZone community and get the full member experience. Join For Free In this blog, Derek Tan, Executive Director of Infra & Simulation at WeRide, describes how engineers leverage Alluxio as a hybrid cloud data gateway for applications on-premises to access public cloud storage like AWS S3. The new data access architecture provides a localized cache per location to eliminate redundant requests to S3.
Synthesis of bicyclic ethers by a palladium-catalyzed oxidative cyclization-redox relay-π-allyl-Pd cyclization cascade reaction
Synthesis of bicyclic ethers by a palladium-catalyzed oxidative cyclization-redox relay-π-allyl-Pd cyclization cascade reaction Michaelyn C. Lux,a Melissa L. Boby,b Joshua L. Brooksc and Derek S.
Two Ads I Like and One I Don't - Derek Tan
A lot is expected of an ad these days: in a short span of time, it has to inform, hold attention, entertain, and become a viral sensation. When we decided to expand Viddsee’s role as a short film platform to include branded content creation a couple of years ago, we knew we had much to learn about the trade.
24 hours with...Derek Tan of Viddsee
7.45am: It is wake-up time, and the first thing I do is feed my 10-month-old boy before having breakfast together with my wife. Okay, okay, I lie: I woke up playing a few minutes of Simpsons Tapped Out, as I have been every morning since 2011 — I figure that if it hasn’t ruined my life by now, there’s no harm in playing it for a few more minutes. I then check into the Viddsee app to see what short film the content team has picked for the day, and mark it to watch for later.
Family-level stereoselective synthesis and biological evaluation of pyrrolomorpholine spiroketal natural product antioxidants
The pyranose spiroketal natural products pollenopyrroside A and shensongine A (also known as xylapyrroside A, ent-capparisine B) have been synthesized by stereoselective spirocyclizations of a common C1-functionalized glycal precursor. In conjunction with our previously reported syntheses of the corresponding furanose isomers, this provides a versatile family-level synthesis of the pyrrolomorpholine spiroketal natural products and analogues.
Rapid assembly of the doubly-branched pentasaccharide domain of the immunoadjuvant jujuboside A via convergent B(C6F5)3-catalyzed glycosylation of sterically-hindered precursors - Chemical Communications (RSC Publishing)
A convergent synthesis of the complex, doubly-branched pentasaccharide domain of the natural-product immunoadjuvant jujuboside A is described. The key step is a sterically-hindered glycosylation reaction between a branched trisaccharide trichloroacetimidate glycosyl donor and a disaccharide glycosyl acceptor. Conventional Lewis acids (TMSOTf, BF ?Et O) were ineffective in this glycosylation, but B(C F ) catalyzed the reaction successfully.
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