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Divya Pathak on Muck Rack

Divya Pathak

As seen in: LinkedIn, The New York Times, ET Travel World, Nature, arXiv, BioRxiv, Cell Press, The Journal of Biological Chemistry, Youth Ki Awaaz, FranchiseIndia.com and
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Articles

Dynamics of the β-cardiac myosin auto-inhibited state explain cardiomyopathy pathogenesis

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By Daniel Auguin, Laurie Lannes, Carlos Kikuti, Nour H. Ayoub, Marie Juillé, Stephane Rety, Neha Nandwani, Divya Pathak, Kathleen M. Ruppel, James A. Spudich, Julien Robert-Paganin, Anne Houdusse
| Nature Verified
Abstract Cardiac contractility requires precise regulation. A recently discovered form of regulation of cardiac contractility involves a β-cardiac myosin off-state, the Interacting-Heads Motif (CarIHM). Despite its central role in cardiac physiology and disease, CarIHM structural dynamics remain poorly understood. Here, we integrate near-atomic resolution cryo-EM with all-atom molecular dynamics to characterize CarIHM in solution and in the context of the filament.
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The hypertrophic cardiomyopathy myosin variant G256E prolongs cardiac muscle relaxation via altered nucleotide handling

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By Kerry Kao, Matthew Carter Childers, Divya Pathak, Rama Reddy Goluguri, Timothy S. McMillen, Kathleen M. Ruppel, James A. Spudich, Michael Regnier Verified, Joseph D. Powers
| Nature Verified
Abstract Mutations in myosin alter its motor functions in diverse ways by affecting different structural and chemo-mechanical events. Multidisciplinary strategies can be used to understand how varying alterations in motor function converge to common phenotypes like hypercontractility and hypertrophic cardiomyopathy (HCM). We combined molecular dynamics (MD) simulations with protein biochemical and myofibril mechanical analyses to study the HCM-causing myosin variant G256E.
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[2501.03547] Metric Criticality Identification for Cloud Microservices

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By Divya Pathak, Felix George, Mudit Verma, Kaustabha Ray
| arXiv
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