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Michael Regnier on Muck Rack

Michael Regnier

Verified
London
As seen in: Wellcome Trust, Nature, The Guardian, The Independent (UK), Digg, MDPI, Quartz, Substack, Medical Xpress, BioRxiv, Cell Press and
A pessimistic utopian writer of sorts. Not currently on X.
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Articles

The hypertrophic cardiomyopathy myosin variant G256E prolongs cardiac muscle relaxation via altered nucleotide handling

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By Kerry Kao, Matthew Carter Childers, Divya Pathak, Rama Reddy Goluguri, Timothy S. McMillen, Kathleen M. Ruppel, James A. Spudich, Michael Regnier Verified, Joseph D. Powers
| Nature Verified
Abstract Mutations in myosin alter its motor functions in diverse ways by affecting different structural and chemo-mechanical events. Multidisciplinary strategies can be used to understand how varying alterations in motor function converge to common phenotypes like hypercontractility and hypertrophic cardiomyopathy (HCM). We combined molecular dynamics (MD) simulations with protein biochemical and myofibril mechanical analyses to study the HCM-causing myosin variant G256E.
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Spatial relationships between vinculin tension and actin at cell adhesions define cell colony positioning and identity

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By Abigail Nagle, Cherry S. Leung, Elaheh Karbassi, Michael Regnier Verified, Jennifer Davis
| Cell Press Verified
Significance In this study, we developed a novel stem cell line to determine the spatial distribution of tension in vinculin, a key cell adhesion protein, to determine cellular colony positioning and cell identity specific mechanical profiles. By utilizing high-resolution microscopy and multidimensional analysis techniques across cells of variable cytoskeletal integrity or across multiple differentiation lineages, we discovered new mechanical determinants of cell type-specific morphologies.
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Dangerous Ideas Needed

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By Michael Regnier Verified
| Substack
More than a week after Charlie Kirk’s assassination, the shock waves are still rolling through higher education. Kirk’s murder, on a college campus, in the act of open debate, was committed by a killer who reportedly believed that “Some hate can’t be negotiated out.” Although the assassin was a college dropout, his apparent logic was very familiar on campus: some ideas are just “hate,” and the normal rules don’t apply. Hate has no home here, as the saying goes.
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