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Donna L Farber on Muck Rack

Donna L Farber

As seen in: The New York Times, Nature, Wiley Online Library, PLOS, The Wall Street Journal, Genome Medicine, Science Magazine, BioRxiv, Cell Press, Cell Reports and
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Articles

Distinct transcription factors control tissue adaptation and effector function in infant and adult memory T cells

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By Peter A. Szabo, Péter Szabó, Hanna M Levitin, Siddhi Nargund, Thomas Connors, David Chen, Jenny Jin Verified, Puspa Thapa, Rebecca Guyer, Daniel Caron, Joshua Gray, Rei Matsumoto, Masaru Kubota, Maigan Brusko, Todd M. Brusko, Donna L Farber, Peter Sims
| Nature Verified
Abstract Early life is essential for establishing memory T cells, which rapidly populate mucosal sites during infancy, although these nascent memory T cells are less protective than their adult counterparts. Here we used single-cell RNA sequencing of resting and CD3+CD28 antibody-stimulated T cells from lymphoid and mucosal tissues of infant (2–9 months) and adult (40–63 years) organ donors to investigate age-dependent mechanisms for functional regulation of human memory T cells.
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Immune development in early life

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By Donna L Farber, Liza Konnikova, Ofer Levy
| Nature Verified
Abstract The perinatal period of immune ontogeny reflects prenatal, maternal and postnatal cues that converge to establish durable immune trajectories. Fetal and infant immunity follows distinct, ontogeny-specific programs optimized for tissue protection, tolerance and rapid effector function. Herein, we integrate recent insights into prenatal hematopoiesis, tissue seeding by innate and adaptive lymphocytes, and the establishment of immune specialization across barriers and systemic compartments.
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The human antibacterial factor APOL3 couples lysosomal damage to mitochondrial DNA efflux and type I IFN induction

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By Dominic A. Ritacco, Hamna Shahnawaz, Antonia Oduguwa, Jacob Hawk, Brianna Vizcaino, Donna L Farber, Ryan Gaudet
| Cell Press Verified
Keywords lysosome mitochondrion interferon innate immunity viruses intracellular bacteria damage DNA Introduction Lysosomes are vulnerable to damage by the material they transport. As the endpoint of endocytosis, phagocytosis, and autophagy, these organelles are continually threatened with a barrage of infectious (bacteria, viruses) and non-infectious (particulates, crystals, toxins) insults.
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