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Durga Anand

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Articles

Coronavirus protein interaction mapping in bat and human cells reveals network rewiring governing immune evasion and zoonotic potential

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By Jyoti Batra, Magdalena Rutkowska, Yuan Zhou, Chengjin Ye, Rithika Adavikolanu, Janet M. Young, Martin Gordon, Shivali Malpotra, Anastasija Cupic, Thomas Kehrer, Mélanie Dos Santos, Ronald Benjamin, Jack M Moen, Declan M Winters, Vincent Caval, Ajda Rojc, Ignacio Mena, Sadaf Aslam, Carles Martínez-Romero, Zain Khalil, Fernando Villalón-Letelier, Dafna Tussia-Cohen, Amy Diallo, Sourobh Maji, Monita Muralidharan, Irene Chen, Lorena Zuliani-Alvarez, Promisree Choudhury, Kirsten Obernier, Ségolène Gracias, Rahul Suryawanshi, Boris Bonaventure, Carlos Ibanez, Jeffrey Johnson, Javier Juste, Lars Pache, Robert M. Stroud, James Fraser, Harm van Bakel, Melanie Ott, Tzachi Hagai, Nolwenn Jouvenet, Caroline Demeret, Benjamin J. Polacco, Danielle L. Swaney, Ignacia Echeverria, Mehdi Bouhaddou, Manon Eckhardt, Harmit S. Malik, Luis Martinez-Sobrido, Lisa Miorin, Adolfo Garcia-Sastre, Nevan J. Krogan, Durga Anand, Sooraj Verma, Haripriya Parthasarathy, Isabela Conde Viñas, Keith Farrugia, Atoshi Banerjee, Helene Foussard, Rotem Fuchs, C.J. San Felipe
| Cell Host & Microbe Verified
Results Bats serve as natural reservoir hosts for a wide range of emerging viruses, including SARSr-CoVs, yet the molecular mechanisms that govern coronavirus replication and host restriction in bat cells remain poorly defined. To investigate these mechanisms, we sought to develop an in vitro model to study host-virus interactions and characterize cellular response to SARS-CoV-2 infection in a bat-host context. To date, most SARSr-CoVs have been identified in horseshoe bats.
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