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Emily Ling-Lin Pai

As seen in: PNAS, Cell Press, Cell Stem Cell, Stem Cell Reports
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Articles

Cholinergic neuron-to-glioblastoma synapses in a human iPSC-derived co-culture model

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By Yusha Sun, Xin Wang, Zhijian Zhang, Kristen Park, Yicheng Wu, Weifan Dong, Daniel Zhang, Yao Fu, Feng Zhang, Zev A. Binder, Emily Ling-Lin Pai, MacLean P. Nasrallah, Kimberly M. Christian, Donald M. O’Rourke, Nicolas Toni, Guo-li Ming, Hongjun Song
| Stem Cell Reports Verified
ReportOnline now102534Open access 1Neuroscience Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA 2Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA 3Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA 4Glioblastoma Translational Center of Excellence, The Abramson Cancer Center, Perelman School of...
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Patient-derived glioblastoma organoids as real-time avatars for assessing responses to clinical CAR-T cell therapy

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By Meghan T. Logun, Xin Wang, Yusha Sun, Stephen J. Bagley, Nannan Li, Arati Desai, Daniel Zhang, MacLean P. Nasrallah, Emily Ling-Lin Pai, Gabriela Plesa, Donald I. Siegel, Zev A. Binder, Guo-li Ming, Hongjun Song, Donald M. O’Rourke
| Cell Stem Cell Verified
Keywords glioblastoma patient-derived tumor organoid ex vivo CAR-T cell therapy real-time correlative clinical trial organoid cytokine Get full text access Log in, subscribe or purchase for full access. References 1. Drost, J. ∙ Clevers, H. Organoids in cancer research Nat. Rev. Cancer. 2018; 18:407-418 2. Jiang, X. ∙ Oyang, L. ∙ Peng, Q. ... Organoids: opportunities and challenges of cancer therapy Front. Cell Dev. Biol. 2023; 11, 1232528 3. Wang, X. ∙ Sun, Y. ∙ Zhang, D.Y. ...
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Enhancing WNT Signaling Restores Cortical Neuronal Spine Maturation and Synaptogenesis in Tbr1 Mutants

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By Siavash Fazel Darbandi, Emily Ling-Lin Pai, Amanda Everitt
| Cell Press Verified
Highlights • Tbr1 promotes and maintains spine maturation and synaptogenesis through WNT signaling • Promoting WNT signaling rescues dendritic spine and synaptic defects in Tbr1 mutants • TBR1 directly regulates transcriptional circuits that control ASD-risk genes Summary Tbr1 is a high-confidence autism spectrum disorder (ASD) gene encoding a transcription factor with distinct pre- and postnatal functions.
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