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Articles by Eric Bindels
PLA2G2D in tumour-draining lymph nodes regulates anti-tumour immunity
Abstract Systemic anti-tumour immunity results from T cell priming in tumour-draining lymph nodes (TDLNs)1,2,3,4. Although the suppression of T cells in tumours is well characterized5,6,7,8, whether this occurs in TDLNs—and if so, through which mechanisms—remains poorly understood. Here, using imaging mass cytometry of TDLNs from patients with melanoma, we identify a spatial neighbourhood in the TDLN paracortex that is linked to the development of distant metastases.
Csnk1a1 E98 mutations rewire signaling and metabolism in del(5q) myelodysplastic neoplasms
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Abstract Deletion of chromosome 5q [del(5q)] is the most common cytogenetic abnormality in myelodysplastic neoplasms (MDS) and results in haploinsufficiency of multiple genes, including CSNK1A1. Recurrent CSNK1A1 mutations, predominantly affecting the E98 hotspot, occur almost exclusively in del(5q) MDS and are associated with adverse outcomes, yet their impact on CK1ɑ function remains unclear.
By Stephani Schmitz, Juliette E Pearce, Gerjanne Vroeg, Stijn Fuchs, Aurelien Dugourd, Giulia Franciosa, Eric Bindels, Wencke Walter, Claudia Meyer, Torsten Haferlach, Emiel P. C. van der Vorst, Oriol Calvete, Francesc Solé, Julio Saez-Rodriguez, Andreas Linkermann, Jesper Velgaard Olsen, Rebekka K. Schneider, Sergio Martinez-Høyer, Inge A. M. Snoeren, Ursula S. A. Stalmann, Hélène F. E. Gleitz
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Nature
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Charting the human-specific properties of gene expression networks in the infant prefrontal cortex
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Human infancy is characterized by protracted brain development coinciding with sensitive periods of extensive synaptic remodeling.
Volume 138 Issue 24
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An inflammatory T-cell-stromal axis contributes to hematopoietic stem/progenitor cell failure and clonal evolution in human myelodysplastic syndrome - Nature Communications
Abstract Myelodysplastic syndrome (MDS) is characterized by bone marrow failure, clonal evolution and leukemic progression, but the pathophysiologic processes driving these events remain incompletely understood. Here, by establishing a comprehensive single-cell transcriptional taxonomy of human MDS, we reveal that inflammatory remodeling of bone marrow stromal niches is a common early feature, irrespective of the genetic driver landscape.
Single-Cell Roadmap of Early Hemato-Endothelial Development: Functions of Atf3, Zfp711 and Bcl6b
Abstract Hematopoiesis is the process of producing blood cells. In mammalian embryos, hematopoiesis occurs in three consecutive overlapping waves (Neo et al. 2021; Dzierzak and Bigas 2018) that are regulated by transcription factors (TFs) and signaling proteins.
Impact of Enteric Neuronal Loss on Intestinal Cell Composition
Abstract Hirschsprung disease (HSCR) is a congenital disorder characterized by the absence of an enteric nervous system (ENS) in the distal gut, causing obstruction and constipation. Despite the known importance of the ENS for normal gut function due to its interaction with other intestinal cells, the impact of ENS loss on intestinal homeostasis remains largely unexplored.
Single-cell transcriptome sequencing allows genetic separation, characterization and identification of individuals in multi-person biological mixtures | Communications Biology
Abstract Identifying individuals from biological mixtures to which they contributed is highly relevant in crime scene investigation and various biomedical research fields, but despite previous attempts, remains nearly impossible. Here we investigated the potential of using single-cell transcriptome sequencing (scRNA-seq), coupled with a dedicated bioinformatics pipeline (De-goulash), to solve this long-standing problem.
Adult human kidney organoids originate from CD24+ cells and represent an advanced model for adult polycystic kidney disease - Nature Genetics
Author notes These authors contributed equally: Yaoxian Xu, Christoph Kuppe. Authors and Affiliations Institute of Experimental Medicine and Systems Biology, Medical Faculty, RWTH Aachen University, Aachen, Germany Yaoxian Xu, Christoph Kuppe, Javier Perales-Patón, Sikander Hayat, Jennifer Kranz, Fabian Peisker, Turgay Saritas, Maurice Halder, Sylvia Menzel, Konrad Hoeft, Hyojin Kim, Claudia R. C.
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