Eric S. Lander on Muck Rack

Eric S. Lander

Cambridge
As seen in: CNN, The New York Times, British Journal of Cancer, Nature, PNAS, Scientific American, The Boston Globe, Science Magazine, Cell Press, Pioneer Press and
Geneticist, mathematician and teacher. Director, Broad Institute of MIT and Harvard. OSTP Director-nominee and Presidential Science Advisor for @JoeBiden
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Articles

Ancient DNA reveals pervasive directional selection across West Eurasia

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By Ali Akbari, Annabel Perry, Alison R. Barton, Mohammadreza Kariminejad, Steven Gazal, Zheng Li, Yating Zeng, Alissa Mittnik, Nick Patterson, Matthew Mah, Xiang Zhou, Alkes L Price, Eric S. Lander, Ron Pinhasi, Nadin Rohland, Swapan Mallick, David Reich
| Nature Verified
Abstract Ancient DNA has transformed our understanding of population history1, but its potential to reveal as much about human evolutionary biology has not been realized because of limited sample sizes and the difficulty of distinguishing sustained rises in allele frequency increasing fitness—directional selection—from shifts due to migrations, population structure, or non-adaptive purifying or stabilizing selection2,3,4,5,6,7.
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Functional dissection of complex trait variants at single-nucleotide resolution - Nature

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By Layla Siraj, Rodrigo Castro, Hannah Dewey, Susan Kales, John C. Butts, Thanh Nguyen, Masahiro Kanai, Kousuke Mouri, Qingbo Wang, Petko Fiziev, Kristin Tsuo, Zachary R McCaw, Sager J. Gosai, Francois Aguet, Ran Ji Cui, Irfahan Kassam, Jeremy F McRae, Christopher M. Vockley, Caleb A Lareau, Sergey A. Abramov, Jeff Vierstra, Yukinori Okada, Alexander Gusev, Thouis R Jones, Eric S. Lander, Pardis Sabeti, Hilary Finucane, Steven Reilly, Jacob C. Ulirsch, Ryan Tewhey, Daniel Berenzy, Alexandr Boystov
| Nature Verified
Abstract Identifying the causal variants and mechanisms that drive complex traits and diseases remains a core problem in human genetics1,2,3,4,5. Most of these variants individually have weak effects6 and lie in non-coding gene-regulatory elements7,8,9,10, for which we lack a complete understanding of how single-nucleotide alterations modulate transcriptional processes to affect human phenotypes5,11,12,13,14,15.
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Public Health: Closing the Gap

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By Ryan McFarland, Eric S. Lander, Alexander Bogdan, Lauren Dybsand
| Minnesota Physician Verified
These are not small changes. For a busy provider, increased confidence means being more likely to start the conversation, deliver a strong, clear recommendation and stay engaged when questions or hesitations arise. It means fewer missed opportunities, more meaningful interactions and ultimately more patients protected against HPV-related cancers.
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