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Erik Jan Hemmer on Muck Rack

Erik Jan Hemmer

As seen in: Cell Reports
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Articles

PLK1 blockade enhances the anti-tumor effect of MAPK inhibition in pancreatic ductal adenocarcinoma

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By Ben Zhao, Rui Fang, Gina Mayer, Marija Trajkovic-Arsic, Kristina Althoff, Jiajin Yang, Laura Godfrey Verified, Sven T. Liffers, Madeleine Dorsch, Barbara M. Grüner, Stephan A Hahn, Smiths Lueong, Jens T Siveke, Hendrik Schürmann, Erik Jan Hemmer, Konstantinos Savvatakis
| Cell Reports Verified
Keywords PDAC MEK trametinib PLK1 volasertib synergism G2/M checkpoint cell cycle JNK KRAS G1 arrest cJUN MAPK therapy resistance PDO organoids Research topic(s) CP: Cancer Introduction Pancreatic ductal adenocarcinoma (PDAC) stands as one of the most lethal malignancies and ranks as the fourth leading cause of cancer-related deaths worldwide.1 Despite significant strides in comprehending the disease’s pathobiology and the introduction of precision oncology approaches, patient mortality rates...
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