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Print production manager, Pagemasters North America (Globe and Mail desk). Former Torstar/StarMetro. Cat enthusiast, pophead, social butterfly. She/her.
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Keywords PDAC MEK trametinib PLK1 volasertib synergism G2/M checkpoint cell cycle JNK KRAS G1 arrest cJUN MAPK therapy resistance PDO organoids Research topic(s) CP: Cancer Introduction Pancreatic ductal adenocarcinoma (PDAC) stands as one of the most lethal malignancies and ranks as the fourth leading cause of cancer-related deaths worldwide.1 Despite significant strides in comprehending the disease’s pathobiology and the introduction of precision oncology approaches, patient mortality rates...
Discussion In this study, pancreatic cancer precursors with gastric and intestinal phenotype were analysed using genomic, epigenomic and transcriptomic approaches to address their molecular profile and assess their cell identity and possible similarity to adult pancreatic cell compartments.