Eynav Klechevsky

Abstract The primary driver of type I diabetes is the autoimmune T cells that destroy insulin-producing β-cells within the islets of Langerhans in the pancreas1. Pancreatic islet macrophages have also been variably linked to disease onset and progression. As macrophage-mediated removal of dying cells through efferocytosis regulates tissue homeostasis and immune responses2, here we investigated how efferocytosis by intra-islet macrophages influences the immune environment of pancreatic islets.

Get full text access Log in, subscribe or purchase for full access. References 1. He, M. ∙ Roussak, K. ∙ Ma, F. ... CD5 expression by dendritic cells directs T cell immunity and sustains immunotherapy responses Science. 2023; 379, eabg2752 2. Chen, D. ∙ Jin, Z. ∙ Chu, H. ... DNASE1L3-expressing dendritic cells promote CD8+ T cell function and anti-PD-(L)1therapy efficacy by degrading neutrophil extracellular traps Cancer Cell. 2025; 43:1758-1775.e8 3. Li, W. ∙ Nakano, H. ∙ Fan, W. ...

Abstract The immunopathogenesis of psoriasis, a common chronic inflammatory disease of the skin, is incompletely understood. Here we demonstrate, using a combination of single cell and spatial RNA sequencing, IL-36 dependent amplification of IL-17A and TNF inflammatory responses in the absence of neutrophil proteases, which primarily occur within the supraspinous layer of the psoriatic epidermis.