Frederick S. Barrett
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An international mega-analysis of psychedelic drug effects on brain circuit function
Abstract Psychedelic drugs are re-emerging as promising scientific and clinical tools. However, despite a rapidly expanding literature on their therapeutic value, the neural mechanisms underlying psychedelic effects remain unclear. Resting-state functional magnetic resonance imaging studies of acute psychedelic effects, conducted independently by several research groups, have so far yielded fragmented and sometimes inconsistent findings.
Teaching a new dog old tricks: bringing rigor, grounding, and specificity to psychedelic neuropsychopharmacology - Neuropsychopharmacology
Psychedelic neuroscience is resurgent. Searching PubMed yields over 6000 articles in the last 25 years, with publications accumulating exponentially over time. Neuroimaging studies have inspired some of the most media-intensive reports on psychedelics. Unfortunately, both journalists and investigators have over-hyped studies with limited methodological and statistical rigor. Resting-state fMRI is the dominant human neuroimaging method in psychedelic research [1].
Misinterpretations and Omissions: A Critical Response to Goodwin and Colleagues’ Commentary on Psilocybin-Assisted Therapy
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