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Gabriella N.L. Chua on Muck Rack

Gabriella N.L. Chua

As seen in: Cell Press, Cell Reports
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Articles

Dpb11 facilitates the colocalization of Mec1-Ddc2 with its activators on gapped DNA

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By Emily C. Beckwitt, Gabriella N.L. Chua, Shixin Liu, Michael E. O’Donnell
| Cell Reports Verified
Keywords: DNA damage response replication stress cell cycle checkpoint Mec1-Ddc2 ATR-ATRIP Dpb11 TopBP1 single-molecule microscopy Research topic(s) CP: molecular biology Introduction The DNA damage and replication stress checkpoint comprises crucial cellular responses for the maintenance of genome stability and prevention of carcinogenesis.1,2 This checkpoint can be triggered by single-stranded DNA (ssDNA) resulting from genotoxic challenges during the G1, S, or G2 phase of the cell cycle.
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Nucleosome spacing regulates linker methylation by DNMT3A2/3B3

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By Xiaoyan Xie, Minmin Liu, Gabriella N.L. Chua, X. Edward Zhou, Michelle Dykstra, Shixin Liu, Peter Jones, Evan J. Worden
| Cell Press Verified
Keywords DNA methylation chromatin cancer nucleosome DNA methyltransferase Introduction Different patterns of methylated CpG (mCpG) dinucleotides play critical roles in establishing constitutive heterochromatin,1,2 directing various developmental programs3,4 and regulating interactions between DNA and various transcription factors.5,6,7 Importantly, dysregulated deposition of mCpG underlies various human diseases including cancer.8 Therefore, proper cell physiology requires highly regulated...
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A non-catalytic role for RFC in PCNA-mediated processive DNA synthesis

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By Gabriella N.L. Chua, Emily C. Beckwitt, Victoria Miller-Browne, Olga Yurieva, Dan Zhang, Bryce J. Katch, Nina Yao, John W. Watters, Kaitlin Abrantes, Ryogo Funabiki, Xiaolan Zhao, Michael E. O’Donnell, Shixin Liu
| Cell Press Verified
Keywords DNA replication DNA damage sliding clamp clamp loader Okazaki fragment genome maintenance PCNA RFC FEN1 Polδ Introduction Genome replication across all domains of life requires DNA sliding clamps that couple with DNA polymerases to achieve processive DNA synthesis.1,2,3 In eukaryotes, this activity is fulfilled by proliferating cell nuclear antigen (PCNA), a homotrimer that forms a ring-shaped complex encircling double-stranded (ds) DNA.4,5 The closed-ring architecture of PCNA...
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